Leukocyte-Rich PRP vs. Leukocyte-Poor PRP: A Guide for Physicians

Platelet-Rich Plasma (PRP) therapy has emerged as a cornerstone in regenerative medicine, offering solutions across specialties such as orthopedics, aesthetics, and sports medicine. While PRP is widely recognized for its ability to promote healing, physicians often face a crucial question during preparation: should they use leukocyte-rich PRP (LR-PRP) or leukocyte-poor PRP (LP-PRP)? Each variation offers unique benefits and is tailored to specific clinical applications. Here’s an evidence-based guide to understanding the differences and how to optimize PRP preparation with Dr. PRP USA’s kits.

Understanding the Basics: Leukocytes in PRP

Leukocytes, or white blood cells, are a critical component of the immune system. They’re found in the buffy coat layer during centrifugation, just above the red blood cells (RBCs). In PRP preparation, the concentration of leukocytes can be adjusted to create either LR-PRP or LP-PRP.

• Leukocyte-Rich PRP (LR-PRP): Contains higher levels of leukocytes, along with platelets.
• Leukocyte-Poor PRP (LP-PRP): Minimizes leukocyte content while maintaining a high concentration of platelets.

The choice between LR-PRP and LP-PRP depends on the treatment’s objectives, as each formulation offers distinct properties.

Applications and Benefits of LR-PRP vs. LP-PRP

Leukocyte-Rich PRP (LR-PRP)

LR-PRP is often used in applications where inflammation plays a key role in the healing process. The leukocytes in LR-PRP contribute to an initial pro-inflammatory response, which can be beneficial in:

• Orthopedics: Treating chronic tendon injuries, such as lateral epicondylitis or Achilles tendinopathy.
• Sports Medicine: Enhancing recovery from ligament or tendon tears.
• Wound Healing: Accelerating the body’s natural repair mechanisms.

The presence of leukocytes can also help reduce microbial contamination, making LR-PRP a preferred choice in settings with a higher risk of infection.

Leukocyte-Poor PRP (LP-PRP)

LP-PRP, on the other hand, is ideal for treatments where minimizing inflammation is crucial. Its anti-inflammatory profile makes it a go-to option for:

• Aesthetics: Facial rejuvenation, hair restoration, and improving skin texture.
• Orthopedics: Addressing cartilage repair or osteoarthritis, where inflammation could exacerbate symptoms.
• Chronic Pain Management: Reducing irritation in sensitive areas.
• Ophthalmology: eye drops for restoration of tear ducts

By limiting leukocyte content, LP-PRP provides therapeutic benefits without triggering excessive inflammation.

How to Prepare LR-PRP and LP-PRP with Dr. PRP USA Kits

With Dr. PRP USA kits, the process of preparing LR-PRP or LP-PRP is both simple and efficient. Here’s a step-by-step guide:

1. Centrifuge the Blood Sample: Follow the recommended time and RPM settings provided in the kit. These protocols ensure optimal platelet concentration while maintaining the integrity of the sample.
2. Identify the Buffy Coat Layer: After centrifugation, locate the buffy coat—a thin layer between the plasma and the red blood cells.
3. For LR-PRP:
   • Include a small amount of the RBC layer along with the buffy coat. This will incorporate leukocytes into the final PRP product, resulting in a leukocyte-rich preparation.
4. For LP-PRP:
   • Exclude the RBC layer entirely. Carefully aspirate only the plasma above the buffy coat to create a leukocyte-poor product.
5. Avoid Protocol Adjustments: Resist the temptation to alter centrifuge settings, as this may compromise platelet concentration and overall efficacy.

Choosing the Right PRP for Your Patients

Understanding the specific needs of your patients and their conditions is key to selecting the appropriate PRP formulation. Consider the following:

• Is inflammation desirable or detrimental in this case?
• What are the patient’s goals for treatment?
• Does the treatment area have a higher risk of infection?

By tailoring PRP preparation to these factors, you can optimize outcomes and provide a more personalized approach to care.

Why Choose Dr. PRP USA?

Dr. PRP USA kits are designed to simplify the PRP preparation process while delivering consistent, high-quality results. With FDA 510(K) cleared systems and robust customer support, we empower physicians to offer cutting-edge regenerative treatments with confidence.

Discover the benefits of Dr. PRP USA’s cutting-edge kits and see how they can elevate your practice.

Order now or call us today at for personalized assistance.

Empower Healing, Transform Lives

When it comes to PRP therapy, precision matters. With Dr. PRP USA kits, you’re equipped to make informed decisions—whether it’s LR-PRP or LP-PRP—ensuring your patients receive the best possible care.