Menu

Platelet-Rich Plasma For Bone Healing

DrPRPUSA-Platelet-Rich-Plasma-Pain-Relief-America
5 Ways Platelet-Rich Plasma Is Relieving Pain in America

Few things are as life-shrinking as chronic pain. Health economists report that chronic pain costs our nation more than $635 billion each year in medical treatment and lost productivity – more than cancer, heart disease and diabetes. Painkillers have been the only relief medication in modern history. That’s changing with Platelet-Rich Plasma. It has been emerging as one of the key players in pain management.

In any life that’s exclusively ruled by pain, Platelet-Rich Plasma has the power to bring back pleasure and normalcy. It’s certainly a better option for those who’re getting by on four or five Advils a day and wondering what the long term consequences would be.

DrPRPUSA-Platelet-Rich-Plasma-Pain-Relief-America

First of all, Platelet-Rich Plasma injections are completely safe. The PRP, prepared by centrifuging the patient’s blood in a special blood tube, works in a two step way. First the injections, often guided by ultrasound, breaks up the tissues and second, the growth factors in the PRP helps rebuild the entire tissue. This produces a healing effect and reduces pain.

Here are five common types of pain that can be healed with Platelet-Rich Plasma.

1. Arthritis pain

It’s been well-proven that a few shots of Platelet-Rich Plasma can produce a huge effect for Arthritis patients. It has the potential to…

  • Inhibit inflammation and thus slowing down degeneration
  • Stimulate cartilage formation
  • Kickstart the production of lubricating fluid

These activities in the affected site ends up reducing the pain sensation.

As a long term effect, Platelet-Rich Plasma injections tend to preserve the joints in more than 70% of the cases – as reported by a landmark study in 2013. Recent studies have shown similar results too. They discovered that a two or three injection treatment over a period of 4-6 weeks with Platelet-Rich Plasma does more benefit that similar injection treatments with either Corticosteroids or Hyaluronic Acid. Moreover, the cartilage degeneration was significantly slowed even for patients in advanced stages of Osteoarthritis.

The researchers also conclude that repeating the injections after 6 months ensured better results.

DrPRPUSA-Platelet-Rich-Plasma-Pain-Relief-America

2. Neurological pain

Platelet-Rich Plasma is one heck of a wonder treatment whose healing potential seems to be expanding everyday and seems like it’s only limited by the physician’s imagination. The latest of those new discoveries is in the field of nerve regeneration and the resulting neuropathic pain. Nerve fibers consisting of neurons are very delicate structures and not much has been discovered about its operating mechanism. But recently, platelet rich plasma have been shown to promote the restoration of nerve fibers.

DrPRPUSA-Platelet-Rich-Plasma-Pain-Relief-America

In a study performed at Hasanuddin University in Indonesia, Platelet-Rich Plasma was successful in nerve regeneration for patients with leprosy peripheral neuropathy – a situation where all traditional treatments have failed. Which means PRP injections are effective in restoring sensations when it has been lost. This is remarkable news.

Then there is another study conducted in Greece the shows very encouraging mid-term results regarding PRP for treatment of Carpal tunnel syndrome.

All of this is proof that Neuropathic pain can be alleviated by Platelet-Rich Plasma. This paper by a researcher at the University of Puerto Rico analyses how Platelet-Rich Plasma has been able to eliminate neuropathic pain. He reports that PRP’s ability to promote axon regeneration is the key.

Here’s a video from a Rejuv Medical where a patient explains how she had PRP Injections for Nerve treatments and how it changed her life remarkably.

3. Chronic back pain

Chronic back pain and sciatica are mysterious conditions and physicians generally have a hard time figuring out what’s causing them. They first thing they do is to scan the lower back area for defects. When they find one, they’ll recommend surgery to correct that defect even though they have no idea if that defect is indeed the culprit of the pain. When they can’t find any defects, they end up being puzzled and sent the patient away with a bunch of Advils.

In a spine health forum, a patient explains his situation which was similar. His physician suspected the tears in L4-L5 spine segment to be the causing the pain. But there were minor tears and bulges everywhere, so the physician was confused. The patient ended up having to take 8 Advils a day. Unable to continue with that, the patient skeptically tried Platelet-Rich Plasma injections. He went from not being able to sit back in office or drive in a car (even with those medications) to stopping the medications altogether and going on a family trip overseas. Talk about a dramatic shift in life experience!

Another patient on the same forum describes how she had PRP injection for chronic pain in the cervical spine, and it’s been pain-free for two years.

DrPRPUSA-Platelet-Rich-Plasma-Pain-Relief-America

These kind of stories are supplemented by occasional clinical studies like this where the patients not only had experienced near complete pain relief but also were able to sustain those results for 2 years. This is remarkable for a degenerative disease, aka, a condition that worsens as time goes by. Here are another study conducted in China and another one by Japanese researchers.

4. Joint Pain

In addition to back and knees, almost all other joints are being treated by Platelet-Rich Plasma now. As the science of PRP evolves, the treatment is vigorously gaining popularity with more and more patients demanding it from their physicians. After all, the procedure is incredibly straightforward and is easily understood by most. The physicians hardly need to talk before the patient accepts eagerly.

Hence the doctors are now quick to prescribe Platelet-Rich Plasma for any case of chronic bursitis – in areas like fingers, elbow, toes, hip, shoulders, neck, wrist, ankle, and hip – and the results are almost always positive.

In fact, Platelet-Rich Plasma can be – and must be – prescribed for more than 50% of the musculoskeletal issues that are usually treated with surgery or steroid injections.

DrPRPUSA-Platelet-Rich-Plasma-Pain-Relief-America

5. Post surgical pain

Surgical pain relief is one of the newer areas where Platelet-Rich Plasma is gaining ground. This is primarily to take advantage of the wound-healing and bone regeneration aspects of PRP, but pain-relief is a very evident beneficial side-effect. Some medical perfusionists advice Platelet-Rich Plasma after almost all surgeries including Neurosurgery, Tumor removal surgery, Oral and Maxillofacial Surgery, Head and Neck Surgeries, Reconstructions and Cosmetic Surgery, Orthopedic/Spinal Surgery, Hand and Foot Surgery, Bone Graft Surgery, Cardiothoracic Surgery and Bariatric Surgery.

By cutting short the time it takes to heal from the wounds of surgery, Platelet-Rich Plasma plays a pivotal role in assisting patients get productive as early as possible. And when done in conjunction with surgery, Platelet-Rich Plasma injections are almost always paid for by the insurance provider covering the surgery.

DrPRPUSA-Platelet-Rich-Plasma-Pain-Relief-America

The beginning of the end of orthopedic surgery?

At a time when big hospitals are racing towards a possible automation of orthopedic surgeries, there are some physicians who believe that the rise of Platelet-Rich Plasma together with the rise of stem cell technology marks the beginning of the end for 80% of the orthopedic surgeries. They say science is finally waking up to the fact that human intervention is not the most efficient way of dealing with musculoskeletal issues. Rather, it’s best to provide the necessarily biologics in the form of PRP and stem cells so that the body can invoke it’s own healing.

DrPRPUSA-Platelet-Rich-Plasma-Pain-Relief-America

I hope you agree – because today’s regenerative medical trends are certainly pushing the medical industry in that direction.

If you haven’t started offering Platelet-Rich Plasma – or would like to know some general protocols, we would love to share them with you. Just call us at (844) 377-7787 or email via hello@drprpusa.com.

Stem Cell Platelet-Rich Plasma
Stem Cell Platelet-Rich Plasma: The Best Regenerative Therapy?

To understand why stem cell platelet-rich plasma or co-transplantation of Adipose-derived mesenchymal stem cells and PRP, is such a remarkable idea in regenerative medicine, let’s spend a little time looking at the mechanics of PRP.

Platelet-Rich Plasma’s Role As Repairmen

The one thing that makes Platelet-Rich Plasma a hero in several fields (if not all) of medicine is the fact that the diverse growth factors in it are able to stimulate stem cell proliferation and cell differentiation (the factors that determine effective tissue regeneration and healing) on any part of the body.

These growth factors are abundant in the blood and act as the natural repairmen of tissues.

In the perfect scenario, there’s plenty of blood flow to every part of the body and these “repairmen” are always on-call to address any healing needs that may arise. However, if the injured area has a poor blood supply — especially areas that are constantly move like tendons, ligaments and joints — demand for these repairmen can outgrow supply. Meaning, healing (or regeneration of tissues) is put on hold till further repairmen are available.

The train of Platelet-Rich Plasma then arrives with enough of these repairmen to warrant resumption of healing.

There’s another part of this picture we haven’t talked about so far: stem cells.

As far as Platelet-Rich Plasma and it’s growth factors are concerned, they are mere repairmen. They can’t do the work by themselves. They need the basic raw materials to work with. And that raw material here is the stem cells.

Stem cells are the ones actually being regenerated to form new tissues for healing.

Stem Cells As The Raw Materials For PRP

Stem cells are the only raw materials that PRP works with for regeneration. These are like the fundamental building blocks of all other cells. These cells can be can be guided into becoming specialized cells under the right conditions.

In addition, they can also divide themselves to form new stem cells or new specialized cells.

So for Platelet-Rich Plasma to work well, it needs to be applied to an area with lots of stem cells like the heart, liver, blood vessels etc. Incidentally Platelet-Rich Plasma’s healing properties were first discovered by cardiac surgeons who played with concentrated blood for faster healing of heart after surgery and it showed tremendous promise because stem cells are abundant in heart tissues.

But what if healing is needed in an area where there are not much stem cells?

With the new developments in stem cell technology that can be solved too. Because now we can supply the stem cells to areas where there are less like the joints, ligaments and tendons. For this, scientists usually use “mesenchymal stem cell” or MSCs. These are cells isolated from stroma and can differentiate to form adipocytes, cartilage, bone, tendons, muscle, and skin.

The most easiest way is to harvest it from adipose tissue or fat that we call Adipose-derived mesenchymal stem cells or ADSC.

Stem Cell Platelet-Rich Plasma

Supplying Both PRP And Stem Cells For Regeneration

In regions with hypoxia (poor blood supply) like joints, meniscus tissue, rotator cuff, spinal discs etc the supply of platelets (and therefore growth factors) as well as the stem cells are limited. So what if we supplied both the stem cells and Platelet-Rich Plasma for triggering the regeneration process?

That’s the question these Japanese scientists answered in their research. Here’s another group of scientists who took on the same challenge.

They used Adipose-derived mesenchymal stem cells (ADSC) which is known for their ease of isolation and extensive differentiation potential. These researchers noted that these stem cells often can’t survive in areas of local hypoxia, oxidative stress and inflammation – thereby making them ineffective. However, when Platelet-Rich Plasma (or thrombin-activated PRP) is added to ADSC, it kept them alive for prolonged periods and the growth factors in the Platelet-Rich Plasma triggered cell differentiation and proliferation more easily.

Why This Exact Combination Is The Future

Done this way, both Adipose-derived mesenchymal stem cells (ADSC) and Platelet-Rich Plasma are raw materials for healing that’s already available in plenty in almost every one (there are exceptions of course). That means, for complete healing to take place this combination treatment, still in it’s very primitive stage of development, may have the potential to replace expensive synthetic drugs that carry complex unexplained side effects. The procedure takes our body’s natural healing agents — stem cells from body fat and PRP from blood — and then inject it inside knee or other joints (or other areas where they are insufficient) for regeneration.

Isn’t that like the most wonderful thing ever?

Whether it’s cartilage cell, or a bone cell, or a collagen cell for ligaments and tendons that needs to be healed, all you need is a same-day procedure by a local, but specialized doctor, using the natural ingredients of the body.

I believe this special combo is a huge win for Platelet-Rich Plasma.

Here’s a video from San Diego Center for Integrative Medicine’s Dr. Joseph where he talks in detail about the science of this particular procedure.

The Challenges For Growing Adoption Of This Treatment

We know Platelet-Rich Plasma has safe, yet high-speed recovery potential with it’s multiple growth factors. And it is effective in regenerative healing of cartilage injuries – the most toughest injuries to heal – as well as Osteoarthritis. However the challenges are Platelet Quality. We need to somehow ensure the Platelet-Rich Plasma quality is uniform. Currently it varies from two to several fold above baseline concentration based on donor’s physical condition.

Next we need to identify the exact PRP growth factors that promote ADSC proliferation. Scientists believe growth factors such as basic fibroblast growth factor (bFGF), epidermal growth factor, and platelet-derived growth factor stimulate stem cell proliferation while some growth factors under certain conditions are known to inhibit the process.

The percentage of PRP matters too. 5 percent, 10 percent, 15 percent and 20 percent Platelet-Rich Plasma in ADSC are tested by scientists.

The Only Treatment In Modern Medicine For Cartilage Regeneration

The bottom line is that Stem Cell Platelet-Rich Plasma or ADSC + PRP procedure is the only treatment in modern medicine that has showed cartilage regeneration. So it’s too important to ignore. And it could one of greatest advances that science has brought to the millions of people suffering from serious pain in their joints, knee and spine as well people suffering from all kinds of tendon diseases and injuries.

Stem Cell Platelet-Rich Plasma

Platelet-Rich Plasma For Bone Healing
Platelet-Rich Plasma For Bone Healing: Myth or Fact?

Platelet-Rich Plasma has a proven record for healing soft-tissues and other living tissues. But can it actually heal the bones itself?

This could mean PRP, when applied to an affected area whether it’s an elbow joint or knee or back bone area, actually heals everything within it’s reach including the bones. Is that really why PRP actually works?

Let’s examine.

Platelet-Rich Plasma For Bone Healing

Bones are not just lifeless matter attached to living tissues. It’s as much living as the tissues themselves. And just like the tissues, it’s constantly changing too. The old bone cells are broken down and replaced with new ones in a three-part process called bone remodeling the involves resorption (digestion of old bone cells), reversal (new cells are birthed) and formation (new cells turn into fully formed bones).

This process, just like any other biological processes in the body, requires hormones and growth factors. Some of the names include parathyroid hormone (PTH), calcitriol, insulin-like growth factors (IGFs), prostaglandins, tumor growth factor-beta (TGF-beta), bone morphogenetic proteins (BMP), and plain old cytokines. For this discussion we need to remember only one thing: a large cytokines and growth factors are involved in bone remodeling process.

Which means we accelerate the bone remodeling process by supplying these cytokines and growth factors as suggested by studies like this, this, this, this, this and this.

Why Platelet-Rich Plasma?

Autologous Platelet-Rich Plasma (PRP), being completely “whole and natural” can more closely simulate a highly efficient in-vivo situation that anything else out there that are made up of artificial recombinant proteins. In PRP, we are taking advantage of the biological benefits of growth factors whose functions we know as well as those we do not know of yet. From the 15+ factors we know are in PRP including platelet derived growth factor (PDRF), transforming growth factor-beta (TGF-beta), platelet factor 4 (PF4), interleukin 1 (IL-1), platelet-derived angiogenesis factor (PDAF), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), platelet-derived endothelial growth factor (PDEGF), epithelial cell growth factor (ECGF), insulin-like growth factor (IGF), osteocalcin (Oc), osteonectin (On), fibrinogen (Fg), vitronectin (Vn), fibronectin (Fn) and thrombospontin-1 (TSP-1)… we’re actually supplying a “holistic” set of nutrients for healing that cannot be mimicked by those obtained artificially.

Platelet-Rich Plasma For Bone Healing

Organic Fertilizers For The Body

The PRP difference is like adding chemical fertilizers versus organic fertilizers on plants. Chemical fertilizers are rich in essential nutrients that we know are needed for crops. On the other hand, organic fertilizers supply nutrients not only to the plants but also to the soil, improving the soil structure and tilth, water holding capacity, reduces erosion as well as promote slow and consistent release of nutrients to the plants itself.

Clearly, organic fertilizers are better, aren’t they?

Platelet-Rich Plasma are like organic fertilizers for our body.

Bonus: Strong Antimicrobial Properties

It seems that the Platelet-Rich Plasma’s healing function has synergistic function to anti-microbial properties. A new study confirms that using Platelet-Rich Plasma in surgeries may have the potential to prevent infection and to reduce the need for costly post-operative treatments.

That’s a nice bonus for the organic fertilizer of our bodies. Perhaps, there are more. So why wouldn’t anyone not take advantage of them?

The scope of Platelet-Rich Plasma is growing as the scientific community continues to unearth its inherent properties. PRP is an unignorable, and unavoidable component of healing.

drprp prp kit samples

Stay In Touch - Join For Updates

Join our newsletter by entering your email address. Once you confirm your email, you'll also receive the link to order your samples.

You have Successfully Subscribed!