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Platelet-Rich Plasma Protocols

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Six Reasons To Offer Your Patients Platelet-Rich Plasma

For most musculoskeletal issues, the effects of immunosuppressants, steroids, DMARDs and protein-blocking drugs, never good to start with, usually wanes off after repeated use. And when it does, the patients realize that during the time the symptoms were being masked by these drugs, the disease was actually progressing at a steady pace. By this time though, it may already be in an advanced stage. That’s why more and more patients today are opting for natural biologics like Platelet-Rich Plasma at the earliest possible instead of waiting till all options are exhausted. This is the Self-Healing revolution.

And it’s just getting started.

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The revolution, which some doctors call “the anabolic era of medicine,” has already eliminated the need for certain traditional methods of disease-intervention like invasive joint replacement surgeries and harmful drugs for hundreds of thousands of patients. Here are some very recent patient testimonials so you can get an idea.

Catherine was diagnosed with a rotator cuff problem about 2 years ago and had trouble lifting her arm. After just two PRP injections she’s now feeling really really great. See the video below for more.

George was suffering from Plantar Fascitis which was curtailing his otherwise active lifestyle. He took a year to rehab and tried a couple of other treatments before being referred to this particular doctor for PRP injections. And again, after just two PRP Injections, the pain he’s been suffering for a year was gone.

This is another amazing story. Bodybuilder Greg had suffered a complete tear in his muscle and tendon – doctors told him his condition is untreatable and that he’d have to live with a physical deformation for the rest of his life. After two and a half months and zero progress, he decided to try Platelet-Rich Plasma. Within 16 days, it had healed and today his muscle is 100% back to normal and he’s doing training.

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Hear what he says in the video below.

Although, I am not in anyway claiming that Platelet-Rich Plasma Injection works for everyone, I do believe that almost everyone with a musculoskeletal issue is an excellent candidate for it.

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Most physicians that we talk to (see our clients list here) say they see a success rate upwards of 80% in the chapter with PRP treatments regardless of the condition they treat. In this classic book about PRP, Dr. Bittencourt et al say, in 203 cases they studied including “38 epicondylitis, 45 Achilles tendonitis, 25 patellar tendonitis, 12 hamstring origin (ischial tuberosity) tendonitis, 08 plantar fasciitis, 08 flexor carpi ulnarii tendonitis, 07 pes anserinus tendonitis, 04 biceps femoris tendonitis, 03 iliopsoas tendonitis, 06 athletic pubalgias and 06 biceps brachii tendonitis,” they saw success rates in excess of 75%.

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It’s amazing how they’re utilizing PRP Injection’s therapeutic effects across the board whether its orthopedic healing, wound management, hair regeneration, facial rejuvenation or pain-reduction. NIH says PRP works by “promoting better collagen I deposition, decreased cellularity, less vascularity, and higher glycosaminoglycan content,” whatever that may mean.

That’s why we’re seeing record growth in the Platelet-Rich Plasma market.

It has long ceased being a fad that only a group of sports medicine specialists promote because pro-athletes like Pittsburgh Steeler wide receiver Hines Ward had used it with remarkable success. And certainly has moved beyond the realm of boutique clinics. Instead, thousands of clinics all over the nation are now offering it. It is the wave of the future, still in its early-phase of saturation. And you can be one of the pioneers in the field.

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Here are six reasons why you should start offering Platelet-Rich Plasma for your patients today.

1. Clear and Obvious Results

There would be no point in discussing a treatment if it doesn’t deliver results. You only need to look at ONE SOLID STUDY LIKE THIS to conclude its efficacy because the way Platelet-Rich Plasma works is not unique to conditions treated. Meaning, if it works for tennis elbow, chances are, it will work for achilles heel too. As well as chronic wounds, spine disc regeneration, bone healing, tendinopathy and much more.

That is to say, the science behind Platelet-Rich Plasma is solid. The growth factors within platelets, mainly platelet-derived growth factor (PDGF), basic fibroblast growth factor (bFGF), transforming growth factor β (TGFβ) and vascular endothelial growth factor (VEGF) have been found again and again to be agents capable of healing tissues. PRP was initially tested by dentists in the 1990s for repair of bones after oral surgeries. Since then scores of the physicians have used it to treat the following with excellent success rates.

  • Rotator cuff injuries (study here)
  • Tennis & golfer’s elbow (study here)
  • Hamstring, hip, knee and ankle strains and sprains (study here)
  • Achilles tendinosis & plantar fasciitis (study here)
  • Knee, hip, and other joint osteoarthritis (study here)
  • Degenerative disc disease of the spine (study here)
  • Nerve injury and neurological pain (study here)
  • Chronic ulcers and post-surgical wound healing (study here)
  • Burns, skin grafts, and scar tissue remodeling (study here)

Yes, physicians have successfully used PRP to treat these conditions for OVER A DECADE now. Yet, there are some physicians who’re only now starting to see the possibilities of this autologous healing agent. They’ve been very dismissive about it until now thanks in part due to the healthcare industry’s lackadaisical approach to it.

Fortunately, much of that is changing. The future is looking bright for Platelet-Rich Plasma. A quick search in clinical trials database reveals 101 clinical trials at the time of this writing.

And it has now become a powerful force in modern medicine.

2. Simple outpatient procedure – zero down time

Preparation of Platelet-Rich Plasma is a procedure that puts the latest high-technology protein-blocking drugs to shame (more on that later) in every sense. Prepared using a simple desktop centrifuge in about 10 minutes (not including the time to draw blood), PRP delivers more therapeutic benefits than many other billion dollar drugs used for the same purpose. The entire procedure takes a maximum of 45 minutes and patients can return to their usual daily routine immediately. Plus the produced PRP is capable of remaining sterile and viable for a couple of hours.

And the safety record? Excellent, in all its use cases.

This may be one of the reasons why patients keep coming back for more once they’ve had an initial injection. The more the better they say. (We don’t agree with them though.)

3. Eliminates invasive surgeries in the long run

Platelet-Rich Plasma acts on the body in the most natural way you can think of – by triggering a healing cascade consisting of hemostasis, inflammation and proliferation phases. This is the way our bodies are designed to heal. It doesn’t aggravate the disease by blocking the natural function of cells, which is what almost all other drugs are designed to do. Therefore the earlier your patients have Platelet-Rich Plasma injections, the less likely that things will get complicated enough to warrant a surgery. We’ve heard from doctors again and again that their patients who were prescribed surgery ended up not having surgery for years.

Platelet-Rich Plasma can actually regenerate tissues, muscles, ligaments and even bones. It works like stem cells but with little less dramatic results and none of the side-effects that stem cell treatments are notorious for.

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Here’s what one of the doctors had to say.

4. The Age Of Ortho-Biologics Is Here – There’s No Escape

One of the biggest reasons why physicians don’t start offering Platelet-Rich Plasma sooner is that they mistakenly think that PRP is just a fad and it might vanish entirely a few years later. But the fact is, the biologic era of medicine is here. And Platelet-Rich Plasma is leading it. And in coming years, putting together joints and discs using steel may look primitive as more scientific data emerge in favor of Platelet-Rich Plasma. Some experts suggest that injection therapies may replace up to 70% to 80% of the surgeries in the near future.

In other words, this shift in treatment paradigm is big.

The earlier you get in, the more expertise you gain. There is a reason why some doctors get amazing results with PRP while others struggle to make it work. The reason is clear. The ones that make it work have a thorough understanding of the science behind it, and are confident about the limits and potential of the treatment. In this case, there is no substitute for experience. The sooner you start doing them, the more confident you become in PRP injection therapy. Don’t wait.

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5. No Risk Of Side Effects Or Mutagenic Effects

One of the biggest drawbacks blocking the stem cell treatments from going mainstream is the potential for the treatments to go horribly wrong. Since Platelet-Rich Plasma acts on cells via transmembrane signal cascades and doesn’t modulate the cells and their functions, there can potentially be no harmful effects from using it. That’s why you DON’T NEED FDA approval to start offering Platelet-Rich Plasma treatments.

It also means that aside from occasional patient dissatisfaction with PRP – could happen in less than 10% of the cases – there is nothing else you need to worry about. No further complications, regulatory actions, or lawsuits can arise. If it doesn’t work, fine. You can try some other treatments. Or you can even combine it with other injection treatments, provided the combination does’t negate the effects of PRP – we’re seeing a trend towards that as evidenced by this study where the therapeutic effects were doubled when PRP was added to the treatment.

That’s why your decision to start offering PRP is going to be an easy one.

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6. Low Cost Of Entry And Lower Costs For Patients

As I mentioned earlier, a very low investment in a simple desktop centrifuge like this and the PRP Kit will get you up and going with PRP injection treatments.

And you don’t have to worry about stocking up on expensive drugs or other raw materials. Your cost of goods sold is very low. That can translate to lower costs for the patient.

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But, I’m not suggesting that it will be all a smooth ride with Platelet-Rich Plasma. One of the challenges you may face is generating standardized protocols for different patient use cases. This can take a while due to trial and error – a fact evident in the current literature, where different studies follow slightly different protocols resulting in varied outcome.

So you have to use your expertise in developing protocols to maximize your results. Some factors that may come into play are the activation method, presence of red blood cells, number of spins in centrifuge, proficiency in ultrasonic image guidance, number of leukocytes and photo-activation of PRP.

You may also have to test things like Platelet-Rich Fibrin Matrix depending on your therapeutic needs.

Webinar: Intradiscal Platelet-Rich Plasma Injections

Dr. Gregory Lutz is one of the early pioneers in Platelet-Rich Plasma – he is the author of a prospective, double-blind, randomized controlled study on lumbar intradiskal PRP injections. And here in the video below, Dr. Lutz discusses his experience and provides case examples for PRP treatments.

PRP Vs The Latest FDA-approved $1 Billion Arthritis Drug

This past May(2017), the FDA approved a drug known as Kevzara – an interleukin-6 receptor (IL-6R) blocker. According to the reports, this drug costs patients (or their insurance providers) $39,000 a year and is expected to generate upwards of $1 billion in revenue for the licensing company by the year 2023. This is a drug that offers at best a temporary 66% improvement in signs and symptoms when using with another DMARD – and carries a risk of producing serious immunological disorders as the drug affects the immune system.

Now, in contrast, the autologous, non-immunogenic Platelet-Rich Plasma needs only a couple of injections that has no side effects – all of it produced from a little desktop centrifuge at your local office. No patent licensing fees involved. Sure, the patient has to pay a couple hundred bucks out of pocket, but which one do you think an informed patient will choose?

Come join the revolution by getting started with Platelet-Rich Plasma. Click here or call us at (844) 377-7787 to talk to us. We’ll support you in the setup and marketing of PRP.

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Three PRP Treatments Revolutionizing Skincare
Three PRP Treatments That Are Revolutionizing Skincare

While there are thousands of skincare centers nationwide offering at least one PRP treatment for their customers, most of them doesn’t go beyond the PRP Micro-needling treatment popularized by Kim Kardashian. The reason is – it is the simplest of all Platelet-Rich Plasma aesthetic treatments around and also the most sought-after treatment. This is all good until they realize the immense potential of PRP treatments. What they’re missing out on is the fact that once you’ve made the investment for Platelet-Rich Plasma which includes a centrifuge, PRP kits and staff training, they can start offering a whole suite of treatments for their clients.

Three PRP Treatments Revolutionizing Skincare

Platelet-Rich Plasma’s Quiet Revolution In The Skincare World

One great thing about PRP treatments is that the protocol for obtaining high quality Platelet-Rich Plasma is the same regardless of its application. Whether its joint injuries, osteoarthritis, bone healing, spinal disc regeneration or skin rejuvenation, the process is the same: draw up to 20cc blood from the patient, place it into the centrifuge which concentrates the platelets and then draw out the Platelet-Rich Plasma for immediate application. This simple process coupled with PRP’s vast scope of healing makes it one of the most significant advances in modern medicine. In fact, one physician, Dr. Lewis Maharam M.D. aka The Running Doc, who regularly writes for New York Daily News calls it “the greatest innovation since the invention of MRI.”

That applies to skincare as well. The Platelet-Rich Plasma you obtain from your clients can be used for a number of treatments, the demand for which are only growing. Here are a few ideas – these are probably the most popular/cutting-edge PRP treatments performed by dermatologists and plastic surgeons.

1. Facial Skin Augmentation With Fillers

The topical application of Platelet-Rich Plasma with Micro-needling can help regenerate the degrading skin cells and promote collagen production to keep skin plump and supple. This basic process may be enough for some of your clients. But those who’re looking for more than just skin rejuvenation, you may have to go deeper. To augment the face with natural, feminine volume, you’re going to have to inject Platelet-Rich Plasma deeper into the dermis. This will supply the growth factors to the degraded dermal tissues under the surface.

For volume though, you’ll need a filler. You can either go for a Platelet-Poor Plasma (PPP) based filler (PPP is the left-over from the Platelet-Rich Plasma process – you can read about the process in detail here.) or you can use any Hyaluronic Acid filler like Restylane Lyft.

This combination injection treatment has been proven to work well. One study by Dr. Daniel Sister analyzes the effect of a combination of platelet rich plasma, hyaluronic acid, and succinic acid for facial augmentation. The treatment showed 100% success rate.

The combination treatment seems to be evolving into a new standard in facial augmentation. It’s definitely seeing growing demand.

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2. RePigmentation And Vitiligo Correction With CO2 Laser

Companies spend millions of dollars on research to turn defective cells healthy and to increase the skin’s collagen production. They are looking into DNA technology to pull this off. But adding Platelet-Rich Plasma to existing treatment methods may be a simple and effective way to achieve the same results. Scientists from Cairo, Egypt had recently proven that adding PRP injections to fractional CO2 laser treatment for correcting vitiligo can boost the results by 4X compared to just using the laser alone. This is great news because given that CO2 laser can also be used to treat facial wrinkles, age spots, and acne scars, it seems we can significantly boost the results by combining it with PRP injections.

And if PRP is capable of boosting the effects of CO2 lasers, chances are, it can do the same for some of the other facial resurfacing treatments that you already offer your clients. Isn’t that an amazing opportunity… to offer the same treatments you’ve been administering for years – but only this time it’s significantly more effective with a secret biologic hack? Hundreds of skincare clinics are just doing that. It’s time to get on the bandwagon and start surprising your clients.

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As one of our friend-clinic owner says, PRP treatments have been a big boon to the business (PRP treatment has a 100% “worth it” rating on real self) as even people who’d had total skin resurfacing have responded well with it.

3. Hair Rejuvenation With Auto-injection

Mesotherapy is a well-known treatment that uses painless micro-injections for delivering active ingredients evenly to skin surface. This novel procedure has a reputation for improving the quality results obtained by traditional skin rejuvenation substances like vitamins and peptides. And as many skincare clinics have discovered, there could never have been a more synergistic technology than this for Platelet-Rich Plasma. The Meso Gun, as we call it, can be used to deliver an even amount of Platelet-Rich Plasma to the face, neck, chest, and hands for rejuvenation and reduction of wrinkles and discoloration, to thighs and tummy for treatment of cellulite and stretch marks, and to the scalp for the treatment of hair loss.

The big winner from this pairing of technologies is the hair loss treatment. Platelet-Rich Plasma when administered on the scalp using Mesotherapy works as an “elixir for hair growth” – and here’s a recent peer-reviewed study on Stemcell investigation journal that confirms this. Hair loss treatment is one of the examples where PRP treatment has exceeded the expectations set by the industry.

That’s why we believe this is one of the treatments that every skincare clinic should offer. Hair-loss and thinning of hair affects both men and women and is one of the most popular cause of worry for your clients. It complements the skincare treatments you offer and you’ll see many of your clients thanking you for that.

Contact us at (844) 377-7787 for more information on the Mesotherapy gun.

If You’ve Never Heard Of These PRP Treatments

Some of these treatments are so new – you may have never heard of them before. And that’s a sign that you should offer them immediately. If you have joined the Platelet-Rich Plasma bandwagon, it’s only intuitive to expand your offerings from just a PRP-micro-needling treatment to these in-demand procedures. You can do this with very little changes, if any, to your existing Platelet-Rich Plasma setup. And chances are they will pair well with other treatments you offer whether it’s Kybella injections, Photo laser treatments or dermal fillers.

And if you aren’t offering Platelet-Rich Plasma yet, this post illustrates a whole lot of reasons why you should be. The demand is only getting stronger. The earlier you join, the more you’re likely to prosper from this incredible breakthrough of modern medical science.

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Are You Maximizing Your Clinic’s Potential With PRP?

If you’re getting started right now, give us a call at (844) 377-7787 or head on to our shop to setup your clinic with the right things for Platelet-Rich Plasma. Our proprietary PRP kit makes the Platelet-Rich Plasma extraction process super efficient and produces high quality PRP in far less time than it would take otherwise. You can read more about our PRP Kits here.

Platelet-Rich Plasma is the blockchain of self-healing and it’s here to stay. It will become best friends with almost every aging man and woman either through their need to reverse aging effects or the need to heal musculoskeletal issues. And both group of people will start putting trust in it once they’ve had a chance to try it. That’s why demand for PRP has skyrocketed organically – without the big pharma advertising dollars – over the past few years.

The question is, are you willing to seize its potential?

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The Osteopathic Physician’s Guide to Platelet-Rich Plasma

Even though they’re licensed to perform surgeries, Osteopathic Physicians are primarily trained to keep their patient’s treatments as non-surgical as possible. Furthermore, their philosophy leans towards prevention and overall wellness than on treating diseases. And for these reasons, we believe Platelet-Rich Plasma is one of the best treatment options they have. After all, the Osteopathic profession was founded on the basis of the human body’s innate capacity to heal itself – the very function PRP injections perform.

The Journal of American Osteopathic Association reviewed Platelet-Rich Plasma a while ago and concluded that more studies are needed. Later another study was presented about a surprising case of an 18-year-old high school football player’s rapid healing of muscle injury through Platelet-Rich Plasma. So even though PRP injections are not officially heralded as the future, Osteopathic Physicians stand to gain much, much more than from Platelet-Rich Plasma than others.

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Platelet-Rich Plasma, An Osteopathic Physician’s Best Ally?

Here’s why we think PRP Injections is probably the best treatment to arrive in Osteopathic Physicians hand.

1. PRP is holistic.

Osteopathic Physicians love treating the whole patient, rather than just the disease. And so is Platelet-Rich Plasma, which merely utilizes the body’s own healing mechanism. And it’s not aimed at eliminating just one symptom either. It heals entire areas – this is evident in cases where multiple symptoms are eliminated after administering PRP. For example, there are many cases where female patients experienced sexual revival after being treated with PRP injections for urinary stress incontinence. So even though PRP Injections were pioneered by allopathic doctors – who still are some of its best advocates – Platelet-Rich Plasma basically functions like an Osteopathic medicine. That’s why we think it’s one of the best allies of an Osteopathic Physician.

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2. PRP is a musculoskeletal hero

Depending on the specialization of the Osteopathic Physician, chronic musculoskeletal pain can be one of major issues that they deal with. And we know PRP Injections are slowly becoming the first-line treatments for musculoskeletal issues. For example, some researchers believe PRP should be first-line treatment for Knee Meniscus issues. Last year (2016), Dr Patrick Smith from the University of Missouri, Columbia, published the results of an FDA-Sanctioned, Randomized, Double-blind, Placebo-controlled Clinical Trial on Platelet-Rich Plasma for Knee Osteoarthritis – and they concluded that PRP provided safe and quantifiable benefits. Here’s another systematic review summarizing about 29 of those studies.

3. Limitless potential of PRP is hard to ignore

There is a third reason why all physicians, let alone Osteopathic Physicians, must get acquainted with PRP Injections – and that is PRP’s vast scope of application. Because Platelet-Rich Plasma’s mechanism is generic (and straightforward), it can be safely assumed that if it works on knees, it can work on any joints, muscles, tendons, bones etc. It’s only a matter of time that PRP Injections will be a standard first-line treatment for all musculoskeletal issues. If you’re keen on hard evidence, have a look at these the randomized trials as well as other studies in the NCBI database.

This limitless potential is especially a boon for Osteopathic Physicians as they look at problems through their Unity of Function lens. Because if there is a strain for a patient on the wrist, there may be other areas of the FASCIA that might be linked to the trouble on the arm. In cases like these, multiple Platelet-Rich Plasma injections on different areas can significantly enhance the typical Osteopathic treatments for restoration of balance and freedom to the entire body.

Dr. Peter Lewis, a fellow of the American Academy of Regenerative Medicine, and the clinical director of the Surecell Group, who’s administered over 100,000 PRP injections to 12,000 patients says, “More than 80% of the patients who undergo PRP treatments enjoy very good results. Even people who’ve been told they’d need surgery have a 70% chance that Platelet-Rich Plasma will help them.”

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List of conditions treated by Platelet-Rich Plasma [INFOGRAPHIC]

For your reference, we’ve included a nice INFOGRAPHIC here that lists common PRP treatment areas.

(Click here to download high-resolution version)

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Are these treatments FDA-Approved?

At the time of writing, Platelet-Rich Plasma treatments are not subject to FDA approval. Because all of these treatments are performed on the same day with minimal manipulation of the patient’s blood. This feature places the PRP procedure within the FDA Code of Federal Regulation (CFR) title 21 Part 1270 1271.1 and as such it enjoys exemption. (FDA rule in 1271.15 (b)).

So no, you do not have to follow the traditional FDA regulatory pathway.

If you need more help, call us at (844) 377-7787. Or check out our Platelet-Rich Plasma store.

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5 Ways Platelet-Rich Plasma Is Relieving Pain in America

Few things are as life-shrinking as chronic pain. Health economists report that chronic pain costs our nation more than $635 billion each year in medical treatment and lost productivity – more than cancer, heart disease and diabetes. Painkillers have been the only relief medication in modern history. That’s changing with Platelet-Rich Plasma. It has been emerging as one of the key players in pain management.

In any life that’s exclusively ruled by pain, Platelet-Rich Plasma has the power to bring back pleasure and normalcy. It’s certainly a better option for those who’re getting by on four or five Advils a day and wondering what the long term consequences would be.

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First of all, Platelet-Rich Plasma injections are completely safe. The PRP, prepared by centrifuging the patient’s blood in a special blood tube, works in a two step way. First the injections, often guided by ultrasound, breaks up the tissues and second, the growth factors in the PRP helps rebuild the entire tissue. This produces a healing effect and reduces pain.

Here are five common types of pain that can be healed with Platelet-Rich Plasma.

1. Arthritis pain

It’s been well-proven that a few shots of Platelet-Rich Plasma can produce a huge effect for Arthritis patients. It has the potential to…

  • Inhibit inflammation and thus slowing down degeneration
  • Stimulate cartilage formation
  • Kickstart the production of lubricating fluid

These activities in the affected site ends up reducing the pain sensation.

As a long term effect, Platelet-Rich Plasma injections tend to preserve the joints in more than 70% of the cases – as reported by a landmark study in 2013. Recent studies have shown similar results too. They discovered that a two or three injection treatment over a period of 4-6 weeks with Platelet-Rich Plasma does more benefit that similar injection treatments with either Corticosteroids or Hyaluronic Acid. Moreover, the cartilage degeneration was significantly slowed even for patients in advanced stages of Osteoarthritis.

The researchers also conclude that repeating the injections after 6 months ensured better results.

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2. Neurological pain

Platelet-Rich Plasma is one heck of a wonder treatment whose healing potential seems to be expanding everyday and seems like it’s only limited by the physician’s imagination. The latest of those new discoveries is in the field of nerve regeneration and the resulting neuropathic pain. Nerve fibers consisting of neurons are very delicate structures and not much has been discovered about its operating mechanism. But recently, platelet rich plasma have been shown to promote the restoration of nerve fibers.

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In a study performed at Hasanuddin University in Indonesia, Platelet-Rich Plasma was successful in nerve regeneration for patients with leprosy peripheral neuropathy – a situation where all traditional treatments have failed. Which means PRP injections are effective in restoring sensations when it has been lost. This is remarkable news.

Then there is another study conducted in Greece the shows very encouraging mid-term results regarding PRP for treatment of Carpal tunnel syndrome.

All of this is proof that Neuropathic pain can be alleviated by Platelet-Rich Plasma. This paper by a researcher at the University of Puerto Rico analyses how Platelet-Rich Plasma has been able to eliminate neuropathic pain. He reports that PRP’s ability to promote axon regeneration is the key.

Here’s a video from a Rejuv Medical where a patient explains how she had PRP Injections for Nerve treatments and how it changed her life remarkably.

3. Chronic back pain

Chronic back pain and sciatica are mysterious conditions and physicians generally have a hard time figuring out what’s causing them. They first thing they do is to scan the lower back area for defects. When they find one, they’ll recommend surgery to correct that defect even though they have no idea if that defect is indeed the culprit of the pain. When they can’t find any defects, they end up being puzzled and sent the patient away with a bunch of Advils.

In a spine health forum, a patient explains his situation which was similar. His physician suspected the tears in L4-L5 spine segment to be the causing the pain. But there were minor tears and bulges everywhere, so the physician was confused. The patient ended up having to take 8 Advils a day. Unable to continue with that, the patient skeptically tried Platelet-Rich Plasma injections. He went from not being able to sit back in office or drive in a car (even with those medications) to stopping the medications altogether and going on a family trip overseas. Talk about a dramatic shift in life experience!

Another patient on the same forum describes how she had PRP injection for chronic pain in the cervical spine, and it’s been pain-free for two years.

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These kind of stories are supplemented by occasional clinical studies like this where the patients not only had experienced near complete pain relief but also were able to sustain those results for 2 years. This is remarkable for a degenerative disease, aka, a condition that worsens as time goes by. Here are another study conducted in China and another one by Japanese researchers.

4. Joint Pain

In addition to back and knees, almost all other joints are being treated by Platelet-Rich Plasma now. As the science of PRP evolves, the treatment is vigorously gaining popularity with more and more patients demanding it from their physicians. After all, the procedure is incredibly straightforward and is easily understood by most. The physicians hardly need to talk before the patient accepts eagerly.

Hence the doctors are now quick to prescribe Platelet-Rich Plasma for any case of chronic bursitis – in areas like fingers, elbow, toes, hip, shoulders, neck, wrist, ankle, and hip – and the results are almost always positive.

In fact, Platelet-Rich Plasma can be – and must be – prescribed for more than 50% of the musculoskeletal issues that are usually treated with surgery or steroid injections.

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5. Post surgical pain

Surgical pain relief is one of the newer areas where Platelet-Rich Plasma is gaining ground. This is primarily to take advantage of the wound-healing and bone regeneration aspects of PRP, but pain-relief is a very evident beneficial side-effect. Some medical perfusionists advice Platelet-Rich Plasma after almost all surgeries including Neurosurgery, Tumor removal surgery, Oral and Maxillofacial Surgery, Head and Neck Surgeries, Reconstructions and Cosmetic Surgery, Orthopedic/Spinal Surgery, Hand and Foot Surgery, Bone Graft Surgery, Cardiothoracic Surgery and Bariatric Surgery.

By cutting short the time it takes to heal from the wounds of surgery, Platelet-Rich Plasma plays a pivotal role in assisting patients get productive as early as possible. And when done in conjunction with surgery, Platelet-Rich Plasma injections are almost always paid for by the insurance provider covering the surgery.

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The beginning of the end of orthopedic surgery?

At a time when big hospitals are racing towards a possible automation of orthopedic surgeries, there are some physicians who believe that the rise of Platelet-Rich Plasma together with the rise of stem cell technology marks the beginning of the end for 80% of the orthopedic surgeries. They say science is finally waking up to the fact that human intervention is not the most efficient way of dealing with musculoskeletal issues. Rather, it’s best to provide the necessarily biologics in the form of PRP and stem cells so that the body can invoke it’s own healing.

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I hope you agree – because today’s regenerative medical trends are certainly pushing the medical industry in that direction.

If you haven’t started offering Platelet-Rich Plasma – or would like to know some general protocols, we would love to share them with you. Just call us at (844) 377-7787 or email via hello@drprpusa.com.

TOP PRP TREATMENTS DRPRP DOCTORS
Dear Doctor, These 7 PRP Treatments Are Hot In Your State

It takes 15-20 minutes to draw 20cc of the patient’s blood, mix it with a small amount of citrate and spin it using a special prp kit and a matching centrifuge for producing the Platelet-Rich Plasma you need for most PRP treatments.

That’s what it takes to produce a multi-potential healing aid to speed up your patients’ recovery.

And it’s definitely the best free healing agent that contains growth factors, and platelets which stimulate the influx of macrophages, stem cells and other repair cells.

The Advantages of Doing PRP, The Right Way

Of course, you can create your own PRP easily by putting the blood in a test tube and spinning it in a generic table top centrifuge and no one can tell the difference. However, it may not have any platelets and probably no tissue healing proteins.

If you do it right way, using the right equipment, you can generate PRP with 7x the normal platelet concentrations. This is called Enhanced PRP. You can also use adipose tissue or collagen fibers to hold the PRP material and form a PRP matrix to amplify the effects.

The 5 Type Of Treatments That Are Hot Right Now

People who are new to Platelet-Rich Plasma may have a hard time believing in the scope of healing it offers. The best 5 treatments are the following:

1. PRP Facial Treatments

A whole lot of skin centers thrive just because they are one of the first ones to offer Platelet-Rich Plasma treatments. This is kind of a treatment that doesn’t need much convincing since there’s no side effects and no down time. Popular prp treatments for face include wrinkle reduction, eye bag and dark circle reduction, skin rejuvenation, gum lift (PRP with collagen sponge is injected after removing stitches in the gum), rosacea reduction, lip augmentation (using a combination of fat and PRP, brought to the limelight by Kylie Jenner and Charlotte Crosby), and vitiligo correction (PRP injection in combination with narrowband-ultraviolet B (NB-UVB) phototherapy improves re-pigmentation).

An especially generic and popular treatment is a combination of Platelet-Rich Plasma and Microneedling. When applied, this novel treatment can produce the effect of botox, lipo or facelift for far less cost.

TOP  PRP TREATMENTS DRPRP DOCTORS

2. PRP Hair Loss Treatments

The growth factors in Platelet-Rich Plasma can reverse non-genetical, early-stage hair loss patterns. There is a huge market for this procedure and very little practitioners offering it. It’s one of the areas for Platelet-Rich Plasma that has a huge unrealized potential. Clients also have seen successful results in cases of thinning hair and even beard regrowth.

TOP  PRP TREATMENTS DRPRP DOCTORS

3. PRP For Arthritis And Cartilage Repair

More than $6.4 billion worth of Arthritis treatments were performed in the US in 2013 alone. That number is poised to hit $9 billion by 2020. And study after study are showing how PRP can not only reduce arthritis symptoms but also regenerate the knee cartilage, something which no other mode of treatments have been able to do.

PRP treatments for Temporomandibular Joint Osteoarthritis (TMJ) is one of the most in-demand ones.

TOP  PRP TREATMENTS DRPRP DOCTORS

4. PRP for Anti-Aging

There are several high end products and complicated procedures that are popular in the Anti-Aging market. None can rival Platelet-Rich Plasma in it’s effectiveness and simplicity. Hence there is a high demand for Anti-Aging-related PRP treatments. PRP combined with Microneedling procedure can be used for acne scars, open pores, stretch marks, hand rejuvenation, Lichen Sclerosus (skin condition in vulva), melasma and breast augmentation.

Another popular treatment is injections of fat mixed with PRP to improve the appearance of cellulite on hip and butt.

5. PRP for Pain Relief And Musculoskeletal Healing

Okay, so this is a very broad category where PRP is considered as the first-line treatment. Most talked about treatments in this category are for Achilles Tendonitis, Rotator Cuff, Tennis elbow, MCL Tear, Meniscus Tear, Plantar Fasciitis, Patellar Tendonitis, Piriformis Syndrome (Severe Buttocks Pain), ACL Tear, Failed Spine Surgery, Back Pain, Lower Back Pain, Hip and Pelvic Disorders, Degenerative Disc Disease, Golfer’s Elbow, Acromio-Clavicular Joint Pain, Labaral Tear, Bursitis, Neuropathic Pain Relief (Nerve Regeneration -Platelet Lysates are used where inflammation is an issue), Spinal Stenosis or Neck Pain, Avascular Necrosis (Osteonecrosis) Or Dying Bones.

Unlike the PRP treatments in the other categories, almost all of these PRP treatments in this category are placed under ultrasound guidance directly onto the affected tissue. Patients often see really good results in as little as two weeks.

TOP  PRP TREATMENTS DRPRP DOCTORS

6. PRP For Infertility

The treatment known as Ovarian Rejuvenation where Platelet-Rich Plasma is directly injected to the patient’s ovaries to reverse menopause or heal fertility issues. This treatment can also result in sexual regeneration. However, this is different from those treatments where PRP is injected into vagina for treating incontinence, looseness, dryness and lack of drive.

Another treatment is for reduction of Vaginal Atrophy symptoms using a combination of Lipofilling and PRP.

TOP  PRP TREATMENTS DRPRP DOCTORS

7. PRP treatments for COPD (Chronic Obstructive Pulmonary Disease)

Recently, physicians are also using PRP for treating lung problems such as allergies, asthma and COPD. The Platelet-Rich Plasma is mixed with with saline and inhaled through the nebulizer for regeneration of lung tissues.

It takes 1-2 months for the treatment to take full effect – but patients are seeing great results. One patient with COPD had his best lung condition in 7 years just 2 months after the treatment. Considering that COPD is a huge issue affecting the lives of more than 700,000 Americans every year, this is major feat.

Honorable mentions

PRP for Dry Eyes: This is one of those health categories where Platelet-Rich Plasma surprised everyone with the results. This treatment is catching up fast although PRP hasn’t become the de-facto treatment.

Erectile Disfunction: This is a widely popular treatment with mixed results. The treatment is popular because of it’s low-risk profile and potential high up side (literally!)

The Future Is Looking Bright

In summary, the trend for PRP is strong – and is here to stay. It’s not a one-trick pony. After all, it’s a natural healing mechanism. And the whole procedure takes a maximum of 60 minutes for the patients with zero recovery time.

That’s why thousands of clinics and major medical establishments are making it a standard treatment for many of the medical conditions they specialize in.

We are already seeing huge the demand for PRP treatments. We receive enquiries from patients who can’t find doctors doing PRP treatments in their area – and often times they are willing to travel for the treatments. This shows how bad the demand is.

So are you offering PRP treatments or are you missing out on this easy, life-saving treatment?

Jump on board with the best PRP Treatment accessories. 🙂

Platelet-Rich Plasma Market Trends 2017 2018
Platelet-Rich Plasma Market Poised For A Liftoff in 2018?

As you probably know, Platelet-Rich Plasma treatment is the ONLY treatment that allows us to harness a patient’s innate healing mechanisms quickly and easily (and more economically) to jumpstart the natural healing process.

And it’s the most interesting thing to ever happen in modern medical history for a long long while.

Take the patient’s own blood and spin it to isolate Platelet-Rich Plasma.

And inject it into specific areas to promote healing. It can also be used in gel format for applying on chronic, non-healing wounds.

No other drug, surgery or vaccine in the history of western medicine was able to secure this wide a scope of application that Platelet-Rich Plasma alone enjoys.

And without the side effects that western medicine is particularly known for.

Yes!

Harnessing the body’s natural healing power leads to fewer unintended consequences (aka side effects).

Platelet-Rich Plasma For Athletes

Now, there is one more thing you may not be aware of.

The trend for Platelet-Rich Plasma is inching closer to a tipping point.

By Platelet-Rich Plasma, I mean Pure-Platelet Rich Plasma (P-PRP), Leukocyte-Platelet Rich Plasma (L-PRP), and Pure-Platelet-Rich Fibrin (P-PRF) combined.

A Forecast For Platelet-Rich Plasma Treatments in The USA

Here’s a WARNING:

There are quite a few “market analysis experts” who predict that the Platelet Rich Plasma (PRP) Market is expected to reach US$451.9 million dollars by the end of 2024.

They are DEAD WRONG.

Measured at a valuation of US$160.0 million in 2015…

Platelet-Rich Plasma market could double or triple that amount by the time we enter 2018.

Here’s why. Our research indicates…

There are FOUR segments where interest in Platelet-Rich Plasma are exploding:

1. Hair restoration

2. Skin care and anti-aging

3. Sexual regeneration

4. Pain management

To understand why we’re reaching a tipping point with PRP, let’s look at the latest developments in these 4 segments alone.

Platelet-Rich Plasma Kit Market Trends

1. Platelet-Rich Plasma for Hair Restoration

The Hair Restoration industry is embracing Platelet-Rich Plasma big time. Recently, Atlanta-based Dr. John Cole, the world’s most respected hair transplant surgeon, has been experimenting with his own cutting edge modifications to existing Platelet-Rich Plasma separation procedures.

He has been testing with Ultrasound waves (4.5 MHz) generated from piezoelectric ceramics to prepare PRP with possible higher platelet concentration and less RBCs contamination.

This is a genuine effort on the part of Dr. Cole (his PRP Combined with FUE Procedure was an industry-first) to improve the overall field of hair restoration…

And he picked Platelet-Rich Plasma as the one of his key levers!

To understand why this field is going to explode, you have to see what users are saying. Like this user who posted on Realself website:

For years I’ve tried it all. Started going to Doctors when I was in my late 20’s and have tried Rogaine, Vivascal and other herbal treatments. I finally decided to seek PRP when I saw it on Good Morning America. I’ve had two sets of treatments. First one at the end of June and the second one in August. I’m going to do my third and final one around November. The results are phenomenal. Not only do I see hair growth and yes, it’s still coming in, but the condition of my hair has also improved. It’s healthier and easier to style. I still use rogaine daily but stopped the Vivascal. The difference the PRP made is remarkable.

It’s fascinating that Platelet-Rich Plasma, a relatively new medical innovation can trump years of scientific development and billions in research dollars by the hair regeneration industry.

Here’s what PRIME International Journal of Aesthetic and Anti-Aging Medicine reports on it’s peer-reviewed article on PRP for hair loss:

So far, PRP has shown some very promising results in hair rejuvenation through prolongation of the anagen phase and signaling some complex pathways involved in hair growth cycle. The results showed enhanced proliferation, differentiation, and angiogenesis of the derma papillae cells and stem cells in the bulge. Clinically, observed outcomes included increased hair count and enhanced hair thickness. Additionally, these results were achieved with a relatively acceptable cost and a good safety profile.

That last sentence is a crucial one.

Because traditionally, the recognised treatments for Female or Male Pattern Hair Loss namely androgenic alopecia are things like minoxidil and finasteride that can cause really unpleasant side effects like hair growth in other unwanted areas and loss of libido and sexual dysfunction.

And PRP Treatments have none of that!

And that’s just the first application of Platelet-Rich Plasma that’s poised for a take off in 2018.

Platelet-Rich Plasma In 2017 2018

2. Skin Care, facial correction and anti-aging

Over the last few years, we’ve seen tremendous demand for PRP-related cosmetic procedures. It’s not only just a US-trend. It’s a world-wide trend. There is nothing more powerfully alluring than the promise of harnessing your own healing power to look good.

And the market response says it all.

Americans spent an estimated US$ 59 Million for Platelet-Rich Plasma related cosmetic surgery applications in 2016.

That’s approximately 0.5% of all the money that Americans spend on ALL COSMETIC PROCEDURES IN TOTAL.

And I think that number is way too conservative. There are so many mom and pop skin care centers offering these procedures – often with just a registered nurse on payroll – that the market should be so much bigger by now.

These skin care centers offer a variety of skin treatments with Platelet-Rich Plasma. Skin Tightening, Stretch Marks, Facelifts and Acne Scar Treatments to name a few. They also combine PRP with MicroNeedling and call it Platelet-Rich Plasma Facelift.

But we’ve found that the scope of Platelet-Rich Plasma is even bigger than we thought.

Platelet-Rich Plasma For Skin Rejuvenation

New Trend In Platelet-Rich Plasma For Skin Rejuvenation

The newest trend is turning Platelet-Rich Plasma (or Platelet-Poor Plasma, it’s byproduct) into…

DERMAL FILLERS!

If I say that I’m surprised by how innovative, cost efficient and effective this is, it would be an understatement.

Turning PRP/PPP into dermal fillers is a bloody miracle that is bound to upset the dermal filler industry over time.

Things like Radiesse can cost upwards of $600 while Fat-based fillers can cost $1200 or more. Now, they have to compete with PRP/PPP based fillers that cost providers next to nothing to harvest.

THIS. IS. HUGE.

Especially considering that according to International Society of Plastic and Aesthetic Surgeons (ISAPS), about 3 million dermal filler procedures were conducted worldwide in 2013.

And the secret weapon behind turning PRP/PPP into dermal fillers is this little machine that uses a special heating and cooling algorithm.

That machine is one of the hottest selling products for us in 2016. You can read more about it here.

So we’ve covered the Hair Loss industry and the Skin Care/Anti-aging industry.

Let’s hit the next segment which is the Sexual Wellness industry. OMG.

3. Platelet-Rich Plasma For Sexual Regeneration

Now, if you’re reading this, you probably know Platelet-Rich Plasma’s history for helping men and women restore confidence in themselves and strengthen their relationships.

You know. The Platelet-Rich Plasma for Sexual Regeneration.Sexual Regeneration With Platelet-Rich Plasma Is A New Trend O Shot P Shot

It has given the sexual wellness industry a much-needed breath of fresh optimism – there has never been a more scientific approach to sexual regeneration that doesn’t involve even a tiny dose of side-effects.

Little wonder patients are paying thousands of dollars – and willing to go the extra mile (literally) to undergo this procedure. I think the beauty of Platelet-Rich Plasma is it’s simplicity. It’s so ridiculously easy to explain to your clients and they can see right away that there’s no need to worry about side-effects.

And the clients have reported great results not only in terms of increased sexual pleasure…

…in terms of increased sexual feelings, greater arousal from clitoral & G-spot stimulation, increased lubrication and tightening of the vagina…

But it has a curious positive side effect of relieving urinary incontinence as well!

I think that’s what makes Platelet-Rich Plasma a rockstar treatment – it’s list of positive side effects make it well worth the clients’ money.

Speaking of positive side-effect, the most curious of them all is this:

The Unbelievable Effect Of Platelet-Rich Plasma On Menopause

According to a team of researchers, the most amazing thing they’ve witnessed is that when Platelet-Rich Plasma was injected into the ovaries of post-menopausal women, it restarted their menstrual cycle. (Kudos to the team at Futurism for pointing it out.)

RESTARTED THEIR F**CKING MENSTRUAL CYCLE!

This literally blows the lid off the upper age limit of would-be mothers.

Isn’t this the greatest advancements in western medical history?

No complicated surgeries, no harmful drugs, no artificial interventions.

Just a few simple injections for OUT-OF-THE-WORLD results.

Now let’s look at the last segment where I think Platelet-Rich Plasma is about to become hugely popular.

And that’s pain management.

4. How Platelet-Rich Plasma Is Changing The Pain Management Industry

Right now, at this level of understanding of Platelet-Rich Plasma, it would a huge missed opportunity if you don’t try it for conditions like…

  1. Rotator cuff injuries
  2. Shoulder instability
  3. Tennis and golfer’s elbow
  4. Hamstring and hip strains
  5. Knee sprains and instability
  6. Patellar tendonitis
  7. Achilles tendonitis
  8. Plantar fasciitis
  9. Knee, hip, shoulder and ankle osteoarthritis
  10. Carpal Tunnel Syndrome
  11. Sacroiliac (SI) joint dysfunction

Doctors now consider PRP the first-in-line procedure for these conditions.

However, one surprising – again coming back to it – positive side effect is…

Platelet-Rich Plasma As A Pain Killer

Research studies and clinical practice have shown that injecting Platelet-Rich Plasma immediately after an injury or any other painful instance can be very effective at relieving the pain.

This is because of PRP’s ability to jump-start and strengthen the body’s natural healing signal actually triggers the brain to stop producing the pain response – meaning it signals that the situation is under control.

In addition to pain relief, Platelet-Rich Plasma is also found to have the following functions…

  1. Anti-microbial
  2. Adhesion
  3. Aggregation
  4. Pro-coagulation and clot retraction
  5. Cytokine signaling
  6. Chemokine and growth factor release

That is a complete healing package right there, isn’t it?

So anytime you hear a client complain about pain – think Platelet-Rich Plasma.

Platelet-Rich Plasma Injection Tube

At least that’s what’s happening in Sports Medicine. Look at how the Los Angeles Angels ace Garrett Richards was instantly given Platelet-Rich Plasma injection into his severely damaged right elbow – and not Tommy John surgery as is usually the practice.

If all of this doesn’t make Platelet-Rich Plasma hard to ignore, there’s one more development that completely elevates the game for PRP fans.

Freeze-Dried Platelet-Rich Plasma

Researchers have found a way to make it even easy for using Platelet-Rich Plasma. Instead of freshly preparing and applying immediately after a wound or operative procedure, they found a way to preserve the PRP in advance using freeze-dried PRP (FD-PRP).

And not only that, they found out that freeze-dried PRP contained more growth factors than freshly prepared PRP – almost three times. Here’s a well-detailed article on Nature about that. It even says the results were better when FD-PRP was used.

Fascinating.

This means Platelet-Rich Plasma can now…

  • Have increased shelf life (ideal for repeated applications)
  • Can be offered at even lower costs
  • Provide higher concentration of Growth Factors
  • Cut down the application time with ready-to-use samples

All from a single blood collection.

The process of freeze-drying typically involves rotating in an ethanol bath at −60 °C and then keeping it frozen at −30 °C for the next 4 hours.

These samples are then attached to a vacuum freeze-dryer.

Freeze-dried Platelet-Rich Plasma can be stored for up to 8 weeks according to preliminary research. Not bad.

That, I think crushes one of the important barriers to its widespread adoption.

Last but not least, I want to add the role technology will play in skyrocketing the popularity of Platelet-Rich Plasma in 2018.

Medical Technology Doubles Every 3 And Half Years

Coming back to the market for Platelet-Rich Plasma, analysts’ conservative guess put it at about $160 Million for 2015. That might be right but they’re terribly wrong about the future growth.

As medical technology continue to double every three and half years, our knowledge in Platelet-Rich Plasma will grow exponentially.

We will have more knowledge on how the many growth factors – mainly platelet-derived growth factor (PDGF), Transforming growth factor (TGF)-[1 and 2], Vascular endothelial growth factor (VEGF) – and various other cytokines and their roles in healing.

And there will be newer applications like dermal fillers that Platelet-Rich Plasma will sneak into.

Today, we discussed only 4 medical categories where Platelet-Rich Plasma is making a dent.

There are literally hundreds more.

Conclusion:Platelet-Rich Plasma Is Not The Be-all And End-All Solution

While discussing the rise of Platelet-Rich Plasma, I also feel the need to acknowledge the fact that there are limitations.

Platelet-Rich Plasma isn’t perfect.

The first limitation is that it comes in just one-size – we need a huge insights into how its constituents work and develop new ways of extracting the exact growth factors and cytokines we want. Then we’ll be able to offer custom Platelet-Rich Plasma prescriptions for different situations.

But I believe further discoveries are just around the corner.

Another thing to acknowledge is this: PRP is not the be-all and end-all of all solutions.

Instead, we need to look at it as a healing accelerator that can make medications that previously failed finally work. This is a huge distinction that the critics failed to understand.

It’s not just a remedy – it’s could be remedy for all other remedies.

What a missed opportunity when doctors don’t realize this.

Let’s not forget what Hippocrates, the father of modern medicine has taught us:

Natural forces within us are the true healers of disease. ~ Hippocrates

Platelet-Rich Plasma Technology

Stem Cell Platelet-Rich Plasma
Stem Cell Platelet-Rich Plasma: The Best Regenerative Therapy?

To understand why stem cell platelet-rich plasma or co-transplantation of Adipose-derived mesenchymal stem cells and PRP, is such a remarkable idea in regenerative medicine, let’s spend a little time looking at the mechanics of PRP.

Platelet-Rich Plasma’s Role As Repairmen

The one thing that makes Platelet-Rich Plasma a hero in several fields (if not all) of medicine is the fact that the diverse growth factors in it are able to stimulate stem cell proliferation and cell differentiation (the factors that determine effective tissue regeneration and healing) on any part of the body.

These growth factors are abundant in the blood and act as the natural repairmen of tissues.

In the perfect scenario, there’s plenty of blood flow to every part of the body and these “repairmen” are always on-call to address any healing needs that may arise. However, if the injured area has a poor blood supply — especially areas that are constantly move like tendons, ligaments and joints — demand for these repairmen can outgrow supply. Meaning, healing (or regeneration of tissues) is put on hold till further repairmen are available.

The train of Platelet-Rich Plasma then arrives with enough of these repairmen to warrant resumption of healing.

There’s another part of this picture we haven’t talked about so far: stem cells.

As far as Platelet-Rich Plasma and it’s growth factors are concerned, they are mere repairmen. They can’t do the work by themselves. They need the basic raw materials to work with. And that raw material here is the stem cells.

Stem cells are the ones actually being regenerated to form new tissues for healing.

Stem Cells As The Raw Materials For PRP

Stem cells are the only raw materials that PRP works with for regeneration. These are like the fundamental building blocks of all other cells. These cells can be can be guided into becoming specialized cells under the right conditions.

In addition, they can also divide themselves to form new stem cells or new specialized cells.

So for Platelet-Rich Plasma to work well, it needs to be applied to an area with lots of stem cells like the heart, liver, blood vessels etc. Incidentally Platelet-Rich Plasma’s healing properties were first discovered by cardiac surgeons who played with concentrated blood for faster healing of heart after surgery and it showed tremendous promise because stem cells are abundant in heart tissues.

But what if healing is needed in an area where there are not much stem cells?

With the new developments in stem cell technology that can be solved too. Because now we can supply the stem cells to areas where there are less like the joints, ligaments and tendons. For this, scientists usually use “mesenchymal stem cell” or MSCs. These are cells isolated from stroma and can differentiate to form adipocytes, cartilage, bone, tendons, muscle, and skin.

The most easiest way is to harvest it from adipose tissue or fat that we call Adipose-derived mesenchymal stem cells or ADSC.

Stem Cell Platelet-Rich Plasma

Supplying Both PRP And Stem Cells For Regeneration

In regions with hypoxia (poor blood supply) like joints, meniscus tissue, rotator cuff, spinal discs etc the supply of platelets (and therefore growth factors) as well as the stem cells are limited. So what if we supplied both the stem cells and Platelet-Rich Plasma for triggering the regeneration process?

That’s the question these Japanese scientists answered in their research. Here’s another group of scientists who took on the same challenge.

They used Adipose-derived mesenchymal stem cells (ADSC) which is known for their ease of isolation and extensive differentiation potential. These researchers noted that these stem cells often can’t survive in areas of local hypoxia, oxidative stress and inflammation – thereby making them ineffective. However, when Platelet-Rich Plasma (or thrombin-activated PRP) is added to ADSC, it kept them alive for prolonged periods and the growth factors in the Platelet-Rich Plasma triggered cell differentiation and proliferation more easily.

Why This Exact Combination Is The Future

Done this way, both Adipose-derived mesenchymal stem cells (ADSC) and Platelet-Rich Plasma are raw materials for healing that’s already available in plenty in almost every one (there are exceptions of course). That means, for complete healing to take place this combination treatment, still in it’s very primitive stage of development, may have the potential to replace expensive synthetic drugs that carry complex unexplained side effects. The procedure takes our body’s natural healing agents — stem cells from body fat and PRP from blood — and then inject it inside knee or other joints (or other areas where they are insufficient) for regeneration.

Isn’t that like the most wonderful thing ever?

Whether it’s cartilage cell, or a bone cell, or a collagen cell for ligaments and tendons that needs to be healed, all you need is a same-day procedure by a local, but specialized doctor, using the natural ingredients of the body.

I believe this special combo is a huge win for Platelet-Rich Plasma.

Here’s a video from San Diego Center for Integrative Medicine’s Dr. Joseph where he talks in detail about the science of this particular procedure.

The Challenges For Growing Adoption Of This Treatment

We know Platelet-Rich Plasma has safe, yet high-speed recovery potential with it’s multiple growth factors. And it is effective in regenerative healing of cartilage injuries – the most toughest injuries to heal – as well as Osteoarthritis. However the challenges are Platelet Quality. We need to somehow ensure the Platelet-Rich Plasma quality is uniform. Currently it varies from two to several fold above baseline concentration based on donor’s physical condition.

Next we need to identify the exact PRP growth factors that promote ADSC proliferation. Scientists believe growth factors such as basic fibroblast growth factor (bFGF), epidermal growth factor, and platelet-derived growth factor stimulate stem cell proliferation while some growth factors under certain conditions are known to inhibit the process.

The percentage of PRP matters too. 5 percent, 10 percent, 15 percent and 20 percent Platelet-Rich Plasma in ADSC are tested by scientists.

The Only Treatment In Modern Medicine For Cartilage Regeneration

The bottom line is that Stem Cell Platelet-Rich Plasma or ADSC + PRP procedure is the only treatment in modern medicine that has showed cartilage regeneration. So it’s too important to ignore. And it could one of greatest advances that science has brought to the millions of people suffering from serious pain in their joints, knee and spine as well people suffering from all kinds of tendon diseases and injuries.

Stem Cell Platelet-Rich Plasma

The Beauty Of Platelet-Rich Plasma For Dry Eyes
The Beauty Of Platelet-Rich Plasma For Dry Eyes

The ancient Egyptians had a prescription of incense, myrrh, and lead salt as dry eye remedy in the 1500 BC. Today we have over-the-counter artificial tears and gels that basically do the same thing. Which means there hasn’t been a breakthrough in treating this ocular conditions for about 3500 years.

The condition causes some serious discomfort for patients — beginning with mild irritation to eye-pain to burning sensations. The major problem with artificial tears and gels is that they don’t last long enough. There are a variety of other treatment options like thermal pulsation, IPL and probes to open up the Meibomian Gland Duct, none offers a generic sure-fire long term solution.

Except this one treatment is getting a surprising amount of traction — PRP Serum Drops.

Platelet-Rich Plasma For Dry Eyes

It seems human tears are full of growth factors including cytokines, albumin and vitamins. The artificial tears and gels try to mimic this constitution but is nowhere near as effective. That’s when someone decided to try applying Platelet-Rich Plasma instead. Not only it is made of similar content as the natural tears, but it also has no preservatives, stabilizers and additives found in the artificial stuff.

And boom! It worked, and wonderfully so. Doctors couldn’t stop recommending them.

Platelet-Rich Plasma For Dry Eyes

Here’s How It’s Done

Eye-PRP or PRP Serum For Dry Eyes or Autologous Serum Eye Drops (ASEDs) is obtained by mixing Platelet-Rich Plasma with Saline solution. Platelet-Rich Plasma is made by drawing 20cc blood from the patient’s arm and centrifuging it for a couple of minutes. This is combination of PRP and saline solution has almost the same salinity and PH as that of the actual tears so there’s no issue of stinging or burning.

This ideal concentration for PRP and saline mixture is 20% — for every 40cc of saline solution add 10cc of 100% serum to make 50cc of Eye-PRP. Then they are loaded into 3ml dropper bottles each containing 2ml of Eye-PRP good for about 40 drops. These are to be refrigerated or frozen and dropped into the eyes 2-3 times a day.

Case study of a 74-year-old woman

Here’s one of the numerous case studies that favor the treatment. In the study, one 74-year-old woman with a 3-year history of severe dry eye who had tried various tears, gels, ointments, steroids, azithromycin, cyclosporine and omega-3s, reported amazing results after using Eye-PRP.

The researcher, Edward S. Jarka, OD, MS, of the University of Missouri-St. Louis School of Optometry, says:

“After 3 weeks of 30% PRP concentrate twice a day, and after discontinuing all other medications, she noted some improvement. After 8 weeks she was able to return to contact lens wear and her outdoor activities. She has remained free of discomfort 2 years after discontinuing the PRP.”

Justifiable out of pocket costs

A single blood-draw and centrifuging process using a kit like DrPRP can produce a three-month supply of Eye-PRP drops. It can cost $300 for a patient, which like any other eye-drop medications, are not covered by medical insurance. This is often a barrier for a patient. Over the long term though, the results like the one we mentioned above are priceless. Not only are they able to discard other OTC eye drops, but they eventually dropped Eye-PRP as well and remained symptom-free for years.

Truth is, if you have long term dry-eye symptom, it’d be foolish not to try E-PRP. We’d all want the speedy recovery we need. But for many Americans, this little out-of-pocket medical cost can be an insurmountable wall. Left untreated, dry-eye symptoms can also have an impact on people’s attractiveness.

Platelet-Rich Plasma For Dry Eyes

Also used for epithelial recovery in post-LASIK corneas

Eye-PRP drops are also known to promote the growth and repair of the epithelial layer of the cornea. In fact, Eye-PRP can be used to heal all kinds of epithelial wounds in the ocular surface, especially during post-LASIK recovery. Researchers also found Eye-PRP to be useful to treat recurrent corneal erosion (RCE). According to one research, it has almost permanent results — they monitored each patient participated in the study for an average of 30 months after discontinuation of Eye-PRP and none of the patients experienced recurrent episodes of corneal erosion. Here’s an article by Paul M. Karpecki, O.D., and Diana L. Shechtman, O.D. in the Review of Optometry back in 2011, where the study was mentioned.

If you’re an optometrist or an ophthalmologist, and are looking to offer Eye-PRP for your patients with dry-eye, corneal ulcers and recurrent corrosions…

Here are the key things you need to know.

  • They are extremely easy to prepare if you have a centrifuge and a proper kit like DrPRP.
  • Eye-PRP is usually should be prepared ready-to-use in 3ml droppers and stored in refrigerator.
  • Patients are expected to put 2-3 drops for 3-6 months
  • After stopping the treatment, the results will be almost permanent.
  • Since PRP is a completely natural healing agent, patients’ eyes experience other beneficial properties in addition to the one they’re being treated for.

That’s it for now. Choose wisely. Choose Platelet-Rich Plasma.

Adios Amigo.

Platelet-Rich Plasma Injections Protocol
Platelet-Rich Plasma Injections: Protocol Guide

Almost all sports medicine doctors would agree that there’s no harm in trying Platelet Rich Plasma Injections (PRP Injections) for their patients. After all, there are hundreds of thousands of cases of positive results. All it needs is research to prove it’s worth. Currently there are many independent researches going on from private funding like the one conducted by Dr. Kimberly G. Harmon M.D., director of the Primary Care Sports Medicine fellowship at University of Washington. She just recently received a gift to support her research from UW alumni who I’m guessing firmly believes in Platelet-Rich Plasma (PRP).

While the process of extracting PRP is fairly simple — there are many variants as long as platelets are above baseline levels with at least seven growth factors — many physician are still unsure about what they can and can’t do when it comes to this marvelous procedure. So today I want to take the time to shine light on the fine print.

Platelet-Rich Plasma Injections Protocol

PRP: Protocols, Technique and Safety Endorsements

Protocol/Technique

Usually, the procedure requires the physician/surgeon and an assistant or two to help with the preparation of graft, the maintenance of sterile technique and saving the ultrasound images (if relevant).

Pre-Procedure Considerations

  • There should always be a specific indication associated with a physical exam with confirmed imaging studies such as an ultrasound, Cat Scan, or an MRI before treatment.
  • Proper patient education and a discussion must be had with the patient as well as a signed informed consent prior to the procedure.
  • Contraindications reviewed prior to procedure.

Graft Preparation

  • The patient is to positioned in a comfortable seated or reclining position.
  • Sterile single needles and syringes must be used with proper handling and disposal.
  • Using an aseptic procedure, the proper amount of blood is then drawn from the vein for the PRP procedure.
  • If the blood cannot be obtained from the site the first, time a new site must be used to prevent early activation.
  • Using a sterile technique, transfer the tube of venous blood to the centrifuge. Platelet Rich Plasma should be acquired using a separating device created for autologous blood. Preference is always given to a closed system that will prevent exposure of the blood and its cellular modules to the open air, and permits minimal use of the tissue.

Image Guidance PRP Therapy

  • Real time imaging guidance using ultrasound CT, or fluoroscopy should always be used when performing a PRP injection.
  • If ultrasound is going to be used, the subsequent considerations need to be decided on in advance: For lengthy procedures, PRP injections near the spine and intra-articular injections sterile gel is recommended.
  • Always use sterile probe covers. Cleansing the probe before and after the PRP procedures and observance to sterile technique is sufficient.
  • Guided images and ineradicable markings of the site of the probe position and the needle entry always needs to be made before cleaning the skin where the probe and needle will be inserted.
  • Always apply a bandage or a dressing after the procedure to protect the entry site from germs.

Post-Injection

  • The patient should be monitored for any post PRP procedure complications such as vaso-vagal.
  • The patients should be given their post procedure directions and precautions and any questions should be answered before they leave, they should also have emergency contact information.
  • Patients should also be instructed about the immobilization and any post procedure activity that is allowed and/or not allowed.
  • Post PRP procedure pain prescriptions need to be given to the patient before discharge and any questions they may have about the medication(s) should be answered at this time. The patient also needs to be instructed to avoid NSAIDs till they have healed, are pain free, has full function has returned to the area being treated (or at least to the limited area being treated.
  • Per OSHA guidelines contaminated areas must be disinfected, before the next patient uses the room (area.)
  • The PRP procedure must be documented in detail, which includes a procedure note that contains the following information: date, pre and post procedure diagnosis, name of the procedure, physician/surgeon(s), any assistants, whether or not anesthesia was used, and if so what type, short-term indication of the procedure, a description of the graft preparation, a description of the procedure that includes any/all guidance and instruments used.

Platelet-Rich Plasma Injections Protocol

Follow-up

  • Patients are normally re-examined in 2-6 weeks after the PRP procedure to follow-up on pain, use, the injection site and to discuss any concerns and any future course of action.
  • The patient response of the treatment should be recorded using authenticated outcome measures.
  • Any complications responses and all other relevant information should be logged into in the ICMS tracking system.
  • The consideration for another PRP injection should be the center of the discussion and the patient will be able to make a decision based on the outcome.

Safety

  • With every medical procedure universal precautions must be used including before, during and after the procedure.
  • Risk of infection – PRP is antimicrobial and provides effective protection against most bacterial infections except for Klebsiella, Pseudomonas, and Enterococcus.
  • With the graft being made entirely out of autologous it basically eliminates the apprehension for the transmission of disease unless the graft became contaminated.

Risks to Patient from the Procedure

  • Infection
  • Bleeding
  • Nerve damage
  • Pain
  • Lack of result
  • Loss of limb and death are very rare but possible.

Platelet Rich Plasma: Indications 

Musculoskeletal complaints, require a complete history and exam to find a diagnosis.  Often times, diagnostic studies may be needed and reviewed to understand why prior treatments failed. PRP is usually considered an optional treatment for chronic and subacute conditions.  Commonly, healing slows down or stops all together at the 6-12 weeks’ period following an acute or traumatic injury.  If the patient has not had any improvement for over the first six weeks, it’s probable the healing period has stopped.

Platelet-Rich Plasma Injections Protocol

Platelet Rich Plasma: Contraindications

  • Septicemia
  •  Platelet dysfunction syndrome
  •  Localized infection at the procedure site
  •  Hemodynamic instability
  •  Critical thrombocytopenia
  •  Patient not willing to take the risks involved with the procedure

Relative Contraindications:

  •  Regular use of NSAIDs within 48 hours of the PRP procedure
  •  HGB of < 10 g/dl
  •  Platelet count of < 105/ul
  •  Systemic use of corticosteroids within 2 weeks
  •  Recent illness or fever
  •  Cancer – particularly hematopoietic or of the bone
  •  HGB < 10 g/dl • Platelet count < 105/ul
  • Corticosteroid injection at treatment site within 1 month
  • Tobacco use
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