Menu

PRP Regenerative Therapy

2017-Platelet-Rich-Plasma-PRP-Injections-Research-2
Top Six Reasons Why Platelet-Rich Plasma Injections Fail

The other day we received an email from a person who had Platelet-Rich Plasma (PRP) Injection that failed to produce any results. “Not impressed, did not work for me. Had it done for my back,” she said. Comments like these are charged with emotions as almost all of these patients have paid for PRP injections out of their own pockets. That’s why the same patient also added later “…but did empty my wallet.” For us, her comment was one of the kinder ones. Others, who were really mad at seeing their money wasted, called it a sham, quackery, and “ways for doctors to make money.” We understand this sentiment. And we can’t argue with the fact that these treatments may have been failures.

But the thing is very few people, including some expert physicians understand why these PRP injections fail.

What The Tremendous Popularity Of PRP Means

In the 1990s, there were about 150 new research articles on Platelet-Rich Plasma every year. At least in the Pubmed database. Back then, only a select group of physicians who really understood the treatment actually offered it to their patients. Now, just this year alone, there were more than 600 new articles. The trend line has gone from a gradual climb to a “U curve” or exploding popularity.

Platelet-Rich Plasma PRP Injections Search Results Pubmed Database

And so did the number of physicians offering this treatment.

Certainly, money wasn’t the objective for those physicians – for if it were, the best ways to do it would’ve been to prescribe a battery of tests, drugs and surgeries approved by insurance companies. Instead, the physicians started offering it once they knew well the inherent benefits of an interventional autologous medicine like Platelet-Rich Plasma.

The problem is, not all physicians were that passionate about it.

Some did it because patients asked for it. Some did it because everyone else was doing it. Still others just wanted to experiment with it casually.

2017-Platelet-Rich-Plasma-PRP-Injections-Research

And so not all Platelet-Rich Plasma injections worked. That’s why, as the treatment exploded in popularity, we saw a small portion of those treatments end up being a waste of the patient’s money – and that gets talked about a lot because, as I mentioned above, the patient usually has huge emotional response to the outcome.

But on the other hand, majority of the patients are happy about their results.

“I had it done on my injury and MAN, IT REALLY WORKS!!!”

That’s another response we got on the SAME DAY that this women told us it didn’t work for her. Another physician also told us the very same day, “PRP works great. We have had fantastic results on patients in the office.”

So what’s making the difference?

Why do some PRP treatments work spectacularly while some others turn out to be a dud?

That’s what we’ll explain in the rest of this post here. There are six main reasons why it can fail. Plus a seventh no-so-common reason. Let’s look at them one by one.

2017-Platelet-Rich-Plasma-PRP-Injections-Research

1. Improper Selection of Patients

As much as the Platelet-Rich Plasma injection enthusiasts would like beat the drum of its universality of application, there are certain instances where a PRP injection may be unnecessary. The classic case is demonstrated in the 2015 Double-Blind Randomized, Placebo-controlled Study that showed that PRP injections are NOT beneficial at all.

According to expert researchers we subscribe to, it is clear that this study had selected the WRONG PATIENTS!!!

Here’s what that means. This study, conducted by researchers at Cooper Medical School of Rowan University, New Jersey, was done in the emergency care department where patients who’d just had a ankle sprain were given a Platelet-Rich Plasma Injection.

First of all, ankle sprains are relatively acute medical condition, commonly occurring due to over-stretching and tearing of the muscle or tendon. And they’re usually healed on their own. The thing that emergency care physicians usually do for this condition is to put ice packs or local anesthetic to numb the pain so the patient can rest. For patients who’re very active, their body is able to heal itself from most of these types of ankle sprains very rapidly. For them, a PRP injection might not accelerate healing. On the other hand, because injections break up the tissue and poke holes, it can actually cause unnecessary complications.

That’s why successful studies on Platelet-Rich Plasma Injections are almost always done on chronic wounds and injuries that wouldn’t heal on its own. If you’re out to test PRP’s efficacy, the untreated-by-PRP “control group” should be non-healable so we can determine clearly the effects of PRP.

So definitely, Platelet-Rich Plasma injections are not ideal for emergency care.

2017-Platelet-Rich-Plasma-PRP-Injections-Research

The same is true for patients on the other end of the spectrum. That is the category of patients who’d been on steroids and drugs for a long time and are in the very advanced stages of the disease. Although there might be hope, Platelet-Rich Plasma might not be enough to reverse course here.

The ideal candidate for Platelet-Rich Plasma injection is a patient who has a relatively new, chronic musculoskeletal condition and whose only other option is surgery or heavy steroid/drug use.

2. Use of certain drugs

One of the other reasons why Platelet-Rich Plasma may not be ideal for emergency care patients is that when patients come in with intense pain, it’s a common practice for the ER physician to administer powerful local anesthetics and/or steroids in high dose. The problem with both of them is that they are are known to be toxic to stem cells and growth factors as shown here here, here and here. So if you’re using these steroids, anesthetics or drugs, it is recommended to wait till the patient can get off of them before applying Platelet-Rich Plasma. Otherwise, the toxicity of the chemicals may limit Platelet-Rich Plasma’s ability to recruit stem cells to the area.

For example, the local anesthetic Marcaine is found to be extremely harmful to stem cells even in small quantities. So as a general practice, the patient has to avoid harmful steroids, anesthetics and drugs at the time or up to 48 hours prior to PRP injections.

3. Lack of Rehab

It’s been reported that PRP injection works well when combined with the physical therapy for sports injuries. However, some physicians mistakenly see PRP injections as an alternative to physical therapy. Hence the comparisons like these where PRP is pitted as a rival to physical therapy. The fact is Platelet-Rich Plasma can only supplement the effects of a proper rehabilitation program as illustrated in this study which demonstrated that PRP + physiotherapy is more effective than Dry Needling + Physiotherapy for patellar tendonisis.

There is one thing we need to add to that though. Most PRP injections are done in a way that breaks up scar tissue and triggers new healing response to which the platelets can respond. So the best post-Platelet-Rich Plasma treatment rehab program is one which treats the patients as if they just had an acute injury. Meaning, the physiotherapy regimen following a PRP injection has to aim at square one – stimulation of blood flow to the injured area to provoke the inflammatory response. This is a different approach than the usual where the PT tries to attenuate the inflammatory response.

2017-Platelet-Rich-Plasma-PRP-Injections-Research

4. Under dosing

Under-dosing is a serious problem in this field. If you’re using PRP with below 3X platelet concentration, you’re under-dosing your patients. An example is the PT vs PRP study we highlighted earlier. Not only did they mistakenly conclude that Platelet-Rich Plasma could be an alternative to Physiotherapy, they were severely under dosing the patients by using PRP with 2.1-2.5X concentration of platelets.

Studies have shown that a concentration of at least 1,000,000 platelets/µl is needed for optimal therapeutic benefits. That is 5X the concentration of platelets in normal whole blood. Here is one such study.

That is the very reason why we advocate not using Gel-based PRP Kit for PRP separation. The problem with gel-based kit is that most of the platelets will get trapped in the gel. Instead a kit like DrPRP kit gives you 5X-9X platelets because it uses a mechanical separation process while giving the same 1-step convenience of gel separators.

2017-Platelet-Rich-Plasma-PRP-Injections-Research

5. Using PRP as just another injectate

There is a fundamental difference between Platelet-Rich Plasma based orthopedic intervention and typical modern surgical and drug-based treatment. And that is surgery and the drugs are designed to eliminate symptoms of diseases. For example, pain is one of many symptoms that occur when a certain part of the body is out of balance. By taking a drug, steroid, NSAID or even undergoing surgical correction, the physician hopes that the pain goes away. This approach has led to all the problems that we face in modern orthopedic medicine. Because when we treat symptoms, the underlying problems usually don’t go away.

But scores of physicians look at Platelet-Rich Plasma with that same attitude. They inject Platelet-Rich Plasma expecting the symptoms to go away.

That’s NOT what Platelet-Rich Plasma is for.

Platelet-Rich Plasma is a HEALING AGENT. It’s different. It’s not designed to eliminate symptoms like a drug. The only thing that PRP can do is use the body to heal itself.

So the first task, if you’re an orthopedic surgeon or someone treating a musculoskeletal issue, is to IDENTIFY precisely what’s producing the symptoms. This means looking at the connection between various muscles, tendons and ligaments. Understanding how they work in unison and finding out what’s causing stress in the system. All the muscles and ligaments and tendons are like different pieces of the puzzle – pulling weights in sync with their functions. So if there’s a anomaly in the whole picture, chances are one of the pieces of the puzzle is not able to carry out its job.

For an easy example, a tightness in the hamstring might be a result of a twisted ligament or bone in the back caused by a bad sitting posture. So in addition to injecting PRP to the hamstring, you might also need to inject to the ligament or bone on the back. And advise the patient to change posture.

This is the definition of Interventional Orthopedics.

2017-Platelet-Rich-Plasma-PRP-Injections-Research

And it requires extensive experience on the anatomy – AND delivering precise injections into the weaker links in the musculoskeletal system to improve overall function of the body. This means using image guidance technologies like fluoroscopy (Ultrasound guidance isn’t enough) to accurately place Platelet-Rich Plasma on areas which require healing. These type of injections enable efficient tissue regeneration and healing, and is usually not taught in medical school, residency, or fellowship.

That’s why we encourage physicians who’re offering PRP injections to get certified by taking one of the courses at the non-profit Interventional Orthopedics foundation.

Getting certified in Advanced Injection practices will make your Platelet-Rich Plasma results more consistent. There is a must-have for all physicians offering PRP Injections. It will also educate you on all the different ways regenerative medicine is being used right now.

6. Thinking only about relieving pain

We touched on it a little on the section above, but this is a broad topic that deserves an explanation on its own. Platelet-Rich Plasma as a healing tool is not something that you should make use of when your patients are in pain. Instead, PRP is used for a wide variety of issues that doesn’t involve pain including wound healing, skin aging reversal, wrinkle correction, dry eye syndrome, nerve regeneration, bone union, hair regeneration and even women’s fertility restoration and strengthening the uterus.

The bottom line is… Platelet-Rich Plasma isn’t just a tool for containing pain due to sports injuries. That days are far behind us now. Today, every physician, from the family physicians to neurologists and cardiologists, to fertility specialists and optometrists, to dermatologists and hair restoration experts… everyone uses Platelet-Rich Plasma.

Plus, more and more applications are discovered every day.

Platelet-Rich Plasma, on its own without funding by Big Pharma or the government, has become an integral part of modern medicine.

2017-Platelet-Rich-Plasma-PRP-Injections-Research

BONUS: The 7th Reason Why PRP Injections Fail

7. Super-concentration of Platelets

We know all analogies are imperfect but we like to use the expresso shot analogy when it comes to platelets. Platelets are like expresso shots for healing. But like expresso shots, your body can’t function using expresso shots alone. It needs food. That’s why studies like this one by Giusti has shown that super concentrating the Platelets may not only be useless, it can actually be harmful. What they did was completely isolate Platelets and platelets alone – and applied it in different concentrations on tendon cells to see if higher concentrations hurt or helped. That’s not Platelet-Rich Plasma. That’s just platelets.

And Platelets alone can’t do the job. In fact, it has nothing to support the survival of cells.

Instead, Platelet-Rich Plasma, is rich in Platelets while also including a small portion of RBC, WBC and the plasma serum which contains the nutrients the cells needed to survive.

2017-Platelet-Rich-Plasma-PRP-Injections-Research

That’s why research shows that taking the concentration above 1,000,000 platelets/µl doesn’t necessarily increase therapeutic benefits and as the Giusti study pointed out, it can actually have a detrimental effect.

This may not be an issue for the average physician, but it is possible to make this mistake thinking that higher concentration is better. That’s why we believe choosing the right Platelet-Rich Plasma kit plays an important role.

Because the kit has to produce Platelet-Rich Plasma in the ideal concentration – not just Platelets – so it can work every single time you administer it on patients.

Patent Application By Allan K Mishra

Speaking of the composition of Platelet-Rich Plasma, the famed Stanford researcher and Platelet-Rich Plasma pioneer Allan K. Mishra has recently filed a patent application titled “PLATELET RICH PLASMA FORMULATIONS” which can be found here. In it, Mishra claims he’s identified specific concentration of platelets, red blood cells, and white blood cells for treating treating connective tissue and/or cardiac tissue damage. It’s worth a look if you’re curious.

Add Regenerative Medicine to Your Practice

If you need help in getting started with Platelet-Rich Plasma, don’t hesitate to give us a call at (844) 377-7787 for a quick consultation. We can support you not only in supplying all the necessary equipment, but also provide you with the information you need to be a confident pioneer in this field. We’re looking forward to having you as part of our family.

You can also email us via hello@drprpusa.com or visit our shop to order directly.

Thank you for reading our blog. We love you.:)

2017-Platelet-Rich-Plasma-PRP-Injections-Research

Doctors-Ditching-Steroids-For-Platelet-Rich-Plasma-PRP-Injections
Why Doctors Are Now Ditching Steroid Injections For PRP

The use of immunosuppressive biologics, non-steroidal drugs (NSAIDs) and corticosteroids, collectively known as Anti-Inflammatory Therapeutics (AIT), has been rebuked by many, including well-known MDs. But there are, still, a good majority of family doctors, pain-management specialists, and orthopedic surgeons who routinely prescribe them for arthritis, tendonitis, and bursitis because apparently, there’s no other better alternative. This is evident in the ballooning anti-inflammatory therapeutics market which is projected to reach a valuation of $100 Billion by 2020. But according to researchers, there already exists a better alternative and that is Platelet-Rich Plasma and scores of physicians are now prescribing it as a first line treatment instead of AITs.

Doctors-Ditching-Steroids-For-Platelet-Rich-Plasma-PRP-Injections

Why Anti-Inflammatory Therapeutics?

One of the reasons why AITs are popular is the belief that most musculoskeletal diseases are due to inflammation. It is believed that inflammation is the cause of injuries and pain. But over the years, numerous studies have shown, rather persuasively, that inflammation is a signaling process used by the body to recruit growth factors and cytokines to the tissue microenvironment. While suppressing the inflammation with drugs interrupts this natural process and provides short term relief to the symptoms, in the long run, it prevents structural healing.

Doctors-Ditching-Steroids-For-Platelet-Rich-Plasma-PRP-Injections

But the argument among pro-AIT physicians is that they provide the best short term relief. They claim that a short or two of AITs keeps the situation under control and is not a big deal in the larger scheme of things.

Not true. They have pain-relieving properties but not as dramatic as we may think.

First, corticosteroids are not as the ultimate pain-killers and there are other methods far superior.

Second, neither can NSAIDs be considered the most effective pain-killers and that’s a fact.

Third, the immunosuppressive biologics like DMARDS, cytokine-blockers and TNF-blockers are not effective pain-killers anyway.

But they all have one thing in common. And that is, a long-list of side effects.

The Debilitating Effects of AITs

It would have been acceptable if we could just temporarily harness the whatever little pain-relief that AITs offered while we’re looking for a favorable course of action. But that isn’t the case. Studies show that even a single dose of these AITs can lead to unwanted complications. Let’s take a deeper look.

1. Steroids
Steroids are evidently the most destructive ones. Physicians know that they must prescribe steroids very cautiously. But the problem is once they work, patients may prefer them again and again. Especially athletes who just want to get back in the arena for that final game. After all, who wants to sit on the sidelines when life passes by? Just one more time, they’ll say.

But the long term effects are disastrous. Not only are they hard to get off of, the steroids have the ability to kill mesenchymal stem cells, lead to cartilage loss, and are one of the most common causes of secondary osteoporosis. Scores of athletes and weekend warriors have used steroids to temporarily push away pain only to end up in the surgery table a few years later.

2. NSAIDS

NSAIDs are a totally different beast. Medscape reports that more than 70 million of them are prescribed to patients each year in the United States alone. This is in spite of the warning issued by the Arthritis, Rheumatism, and Aging Medical Information System (ARAMIS) against NSAID use.

To the patient, it sounds like a decent proposal – use non-steroidal drug to temporarily alleviate pain. However, the consequences are enormous. In this comprehensively researched article on the Journal of Prolotherapy, the writer calls for a total ban on the use of NSAIDs for joints owing to its potential for degenerating cartilage. This is alarming considering that majority of the NSAIDs are prescribed for joint conditions like arthritis. In another study, use of NSAIDs was shown to have tripled the progression of Knee Osteoarthritis.

Furthermore, even in the 1980s researchers have found that NSAIDs can disrupt intestinal integrity.

3. Biologics

Anti-inflammatory biologics include drugs that block pro-inflammatory cytokines like tumor necrosis factor alpha (TNF) and interlukin-6 (IL-6) as well as conventional disease-modifying antirheumatic drugs (DMARDs). The problem with these drugs is that they suppress the biologic entities responsible for the natural immunity of the body. Applying them to a joint for example, doesn’t limit its effect to that area. Instead, it suppresses these biologic entities THROUGHOUT the body including liver, colon, small intestine, bones, skin and even neurons.

That’s why they have been linked to neurological diseases, and other diseases.

Blocking pro-inflammatory cytokines are definitely a bad idea. For example, the cytokine IL-6, one of the main cytokines targeted by the new generation of Arthritis drugs is a major component of the central nervous system. So is anti-TNF drugs. Blocking these can only lead to adverse events in the long term elsewhere in the body.

Doctors-Ditching-Steroids-For-Platelet-Rich-Plasma-PRP-Injections

Can PRP Disrupt The Anti-Inflammatory Therapeutics Market?

Although not immediately evident, the trend for these Anti-inflammatory Therapeutics are actually going down. As researchers discover more serious side effects, the market will start shifting to more natural solutions like Platelet-Rich Plasma. In fact, it’s already happening as we speak. Even without the support of insurance companies, more and more people are opting for PRP instead of AITs. That means people are willing to pay out-of-pocket for PRP instead of accepting free drugs. In other words, the downward trend for AITs has begun.

Patients and physicians are learning the hard way that SUPPRESSION OF INFLAMMATION DOES NOT EQUAL TO HEALING.

Doctors-Ditching-Steroids-For-Platelet-Rich-Plasma-PRP-Injections

On the other hand, the trend for Platelet-Rich Plasma is climbing organically.

Here’s Allen Mishra’s tweet about PRP’s Google trends. Alan is the founder of the Biologic Orthopedic Society that has over 6,500 members in Linkedin.

Independent research is also catching up with Platelet-Rich Plasma. It has proved so far that PRP is far superior for:

1. Chronic low back pain

The study shows that sacroiliac joint (SIJ) injection of Platelet-Rich Plasma has a longer-lasting effect on pain than steroids. And the difference is HUGE. While efficacy of steroids was only 25% at 3 months, it was 90% for PRP.

2. Tennis Elbow

In this study, the steroids were only able to suppress symptoms for recalcitrant lateral epicondylitis, while PRP was able to biologically heal the lesion. Furthermore, the steroids caused further tendon degeneration. Another study proved that patients who had PRP shows better pain and functional improvements than patients who had corticosteroid injection.

3. Plantar fasciitis

This randomized, blinded study concluded that PRP delivered at least the same pain-relief results as steroids. Other researchers have concluded that PRP is actually more effective than steroid injection in terms of pain and functional results. Another study also proved that PRP was more effective and durable than cortisone for plantar fasciitis. Yet another British study also pointed out that PRP injections are superior to corticosteroid injections.

Doctors-Ditching-Steroids-For-Platelet-Rich-Plasma-PRP-Injections

4. Knee Osteoarthritis

The study above showed that intra-articular PRP injections are better than HA, ozone, and corticosteroids. Another study recently proved that PRP injections are better than Hyaluronic Acid for knee osteoarthritis.

5. Rotator Cuff Tears

This study proved that Platelet-Rich Plasma injections show benefit earlier than cortisone injections for rotator cuff tears. Another similar study also found that a single dose of PRP is better than steroid for Shoulder impingement syndrome.

Why PRP Is Actually Good For Both Patient And Physician

As you can see, the reason why more and more physicians and patients favor Platelet-Rich Plasma over Anti-inflammatory Therapeutics is that PRP not only eliminates the symptoms (pain and function) but it actually heals biologically. Yes, of course, the manufacturers of the conventional drugs would love you to believe that their billion-dollar-research-backed miracle drug is VASTLY superior to the autologous Platelet-Rich Plasma that can be produced within 10-20 minutes in a small clinic. But what we’ve seen is quite the opposite.

Doctors-Ditching-Steroids-For-Platelet-Rich-Plasma-PRP-Injections

One of the early pioneers of Platelet-Rich Plasma, an orthopedic surgeon Dr. Allan Mishra, M.D., says, that soon this biologic tool would be “safe, simple to use, inexpensive, and available immediately at the point of care.”

And that requires a tipping point in its adoption by physicians. It’s already accelerating at a good pace.

Dr. Mishra goes on to say that, “chronic tendinopathy is the most common indication for applying PRP in my practice. I have used the treatment for tennis elbow, patellar tendinosis, partial Achilles tendon tears and occasionally partial rotator cuff tears as a stand-alone treatment. I also now routinely augment all of my Achilles and patellar tendon repairs with PRP. And I am considering augmenting my arthroscopic rotator cuff repairs as well with PRP. For nonunions or difficult fractures, I combine PRP with bone grafting.”

For the patients, Platelet-Rich Plasma has been helping them avoid surgery for years now. See the videos below for actual testimonials from real patients.

Here’s another patient’s story of how PRP helped avoid surgery.

“When I tore my rotator cuff in 2008, I had conventional laparoscopic surgery to repair it. The outcome was excellent, but the recovery was long and horrible. The orthopedist wouldn’t let me drive for six weeks, or run, swim or lift weights for three months. I suffered through weeks of torturous physical therapy. It was nearly six months before I felt normal again.”

And the patient vowed to never go through that ever again.

Unfortunately, the patient suffered another injury in 2014.

But this time decided to try Platelet-Rich Plasma instead.

The patient said, “I had the first PRP injection on Oct. 23. It was painful, and the aching persisted for about 36 hours. I had one bad night, followed by an uncomfortable day. After that, the pain stopped. Still, my doctor advised me to baby the shoulder — to use my other arm when holding a dog leash and to skip swimming and weights for two weeks. Running was fine. He also recommended physical therapy after two weeks.”

The patient reported that by February 2015, the shoulder was 80% healed. The doctor advised the patient to have a second PRP injection to heal the remaining 20%.

Here’s what the patient said:

“I had [the second injection] on March 4. When I returned to see [the doctor] on April 12, I was feeling pretty good. No pain, no problems. He rolled in the ultrasound machine, and I was not surprised by the results.”

Watch this second video for another excellent patient story.

Get Started On Platelet-Rich Plasma Now

The best way to start making a big difference in your patients, especially if you’re an orthopedic surgeon, rheumatologist or any kind of pain management specialist, is to get going with Platelet-Rich Plasma. Don’t just have it as a back up treatment that you can try when things don’t go well. Instead, it can be used as a standard first-line treatment for musculoskeletal issues.

Give it a serious consideration.

Doctors-Ditching-Steroids-For-Platelet-Rich-Plasma-PRP-Injections

We can guarantee that once you start offering Platelet-Rich Plasma, you’ll end up prescribing less and less Anti-Inflammatory Therapeutics and more and more Platelet-Rich Plasma. And it will have a tremendous impact on the lives of your patients. We want to see a world where the “replacement surgeries” are a thing of the past.

And Platelet-Rich Plasma can make it happen.

Give us a call if you need more information. We can be reached at (844) 377-7787 or email via hello@drprpusa.com. Or you can order a Platelet-Rich Plasma kit online and try it in your practice.

Together, let’s welcome the Anabolic Era of Medicine.

Doctors-Ditching-Steroids-For-Platelet-Rich-Plasma-PRP-Injections

Six-Ways-Platelet-Rich-Plasma-PRP-Injections-Save-Money-For-Patients
Six Ways Platelet-Rich Plasma Saves Your Patient’s Money

In 2011, Stanford University researcher Jason L. Dragoo, reported that there are over 86,000 PRP Injections performed in the US each year. Market analysis by exerts put the growth rate of the Platelet-Rich Plasma market at almost 12% compounded rate which means that the number is probably 170,000 this year. Yes, well over 170,000 PRP injections are performed annually in the US. A recent scientific research by Russian researchers claim that patients save about US$876.84 on average when choosing Platelet-Rich Plasma over conventional treatments. This researchers included only data for PRP applied for wound healing. But we believe the savings for sports injuries and arthritis patients to be much higher. That’s a WHOPPING $149 million in COSTS SAVED BY PRP INJECTIONS in the US alone.

And we’re just scratching the surface here.

Six-Ways-Platelet-Rich-Plasma-PRP-Injections-Save-Money-For-Patients

Skyrocketed During The Past 5 Years

Stephen Clark, PT, DPT, MBA, OCS, president and founder of Athletic Physical Therapy in Los Angeles, notes that “the number of physicians performing PRP procedures has skyrocketed during the past 5 years.” This correlates to the aggressive demand we’re seeing for this safe and autologous treatment. The patients can’t find enough physicians performing the procedure. We receive inquiries from patients wanting to do the treatments and some are even willing to go out of state if there’s none in their area.

Watch this response from this patient about her PRP injections.

And patients like Ken below come back for more after their initial injection.

The science, however, is just catching up with this trend. Recent FDA-Sanctioned, Randomized, Double-blind, Placebo-controlled study and Meta-analysis of Level 1 Randomized Controlled Trials continue validating Platelet-Rich Plasma’s role as a better therapeutic tool than conventional treatments.

Six-Ways-Platelet-Rich-Plasma-PRP-Injections-Save-Money-For-Patients

Six Ways Patients Save Money When You Offer Them PRP

The big stumbling block for PRP is insurance acceptance. Right now, the insurance companies gleefully ignore the 0232T code – the CPT code for Platelet-Rich Plasma injections, with or without image guidance including its harvesting and preparation. But as they’ll soon realize, not accepting PRP injections is actually costing them a lot of money down the road. That’s why many physicians we talk to believe that it’s only a matter of time before the insurance start accepting it.

But even if it remains that patients have pay out of the pocket for these injections, it still is a very cost-efficient way for them to deal chronic injuries and degeneration.

Here are six ways we know.

Six-Ways-Platelet-Rich-Plasma-PRP-Injections-Save-Money-For-Patients

1. Symptom management vs true healing

Typical drug-based approach to healthcare is more symptom management than true healing. This is because the drugs typically do nothing to promote the reversal of the root cause. Instead, they’re good at masking the symptoms. The implications of this are vast when it comes to cost. Since the root cause is not addressed, the patient becomes dependent on the drugs as the disease progresses and symptoms recur. Each time they’re given a stronger dose or a different drug until it no longer works.

Now, compare that to Platelet-Rich Plasma’s approach to actually correct the root cause by promoting healing of the broken or degenerated tissues. Often patients are healed by just one or two injections. And they’re happy for years.

In the long run, the patient who’d had Platelet-Rich Plasma Injections are less likely to develop complications leading to surgery.

Six-Ways-Platelet-Rich-Plasma-PRP-Injections-Save-Money-For-Patients

2. Eliminate surgeries

This is huge. Analysts estimate that there are over 600 thousand knee-replacement surgeries performed every year. When people think of the cost of these surgeries, even minimally invasive ones, they only look at the hospital bill that may be covered by the insurance provider. But there are numerous other costs like loss productivity due to patient’s downtime, psychological costs, and even miscellaneous costs during the patient’s stay in the hospital.

Moreover, stuff like arthroscopic surgery, the most common orthopedic surgical procedure, has a history of leading to further deterioration and arthritis.

So the patient’s actual costs are high.

All of these are eliminated when you suggest your patients choose Platelet-Rich Plasma at an earlier stage.

3. Complications, scars or downtime

According to this paper, post-surgical complications can exceed $10,000 for each patient. That is just for surgeries. What about complications due to side effects of drugs? Research indicate that it’s about $1300 per adverse drug reactions.

In fact, medical complications and side effects are some of the biggest cost burdens associated with modern western medicine.

Then there are scars associated with surgeries. Not to talk about downtime.

Platelet-Rich Plasma on the other hand would have none of that troubles. This risk of injection is extremely low since it’s all autologous. And the procedure is done on an outpatient basis after which the patient can return to normal activities the following morning.

All of these translates to increased savings every time you recommend Platelet-Rich Plasma for your patients.

4. Multi-potential therapeutic effects

One of the problems with FDA-approved drugs is that they can only be prescribed for the stated purpose of use. A drug for arthritis patients can only be prescribed for arthritis patients even if it might help a patient with tendonitis. Thus if the patient has more than one orthopedic conditions, chances are each one will need different drugs specifically approved for that condition. Take arthritis and osteoporosis – they are treated completely different when using FDA-approved injections.

On the other hand, Platelet-Rich Plasma is multi-potential. It can be injected on…

  • Knees to heal meniscus, ACL, MCL and arthritis
  • Shoulder to heal rotator cuff tears and tendonitis
  • Hip to heal labrum and bursitis
  • Low Back to heal spinal degeneration and sciatica
  • Foot to heal Plantar Fasciitis, Achilles heel and ligament sprains
  • Elbows to heal lateral epicondylitis and medial epicondylitis
  • Bone to aid the union of fractured bones

You get the point. The possibilities are endless.

This means that the patient do not have to get an assortment of drugs if they need relief for multiple symptoms and thus there is no cost of acquiring new drugs (or potentially leaving drugs unused) each time they have a symptom.

Six-Ways-Platelet-Rich-Plasma-PRP-Injections-Save-Money-For-Patients

5. No research and marketing costs are added

This is one of the main advantage of Platelet-Rich Plasma injections. Unlike FDA-regulated drugs, for which the companies spend millions of dollars for research, several times more on marketing and mass production, there’s little capital costs involved with Platelet-Rich Plasma.

To produce it, all you will need to invest in is a good PRP Kit and a centrifuge and the patients can come and get the PRP injections unlimited number of times.

All the research on Platelet-Rich Plasma is done by independent researchers around the world and there’s one no single entity who’s licensing it. So customers aren’t paying for bloated research funding and marketing costs.

This means you can afford to charge your patients less.

6. Outpatient treatment, benefits small and independent clinics

The process of getting admitted to a hospital is mentally taxing. And most of the surgical procedures, however minimal require hospitalization. And that means you need big equipments and all sort of things. So only big hospitals can do those. There is an endless list of charges that the hospital needs to include as a standard and depending on the co-pay agreement with their insurance, the patients may end up paying anywhere from 10% to 50% of these extra unnecessary charges.

With Platelet-Rich Plasma, though, it is an outpatient treatment done in small, independent clinics as a 45-minute procedure. And these clinics are very cost-efficient in their operations because they do not need to employ a lot of staff.

The takeaway? Patients pay significantly less compared to surgeries. And the small, independent clinics have a big advantage over large hospitals.

As a last resort I had two injections of PRP

Platelet-Rich Plasma is here to stay. The skyrocketing demand is proof. And there is no reason why you shouldn’t be offering it. Thousands of cases prove that it works. We’ve shown you how it saves your patients money.

If you’re an orthopedic surgeon, rheumatologist, and/or run a pain management clinic, you’re doing a tremendous disservice to your patients if you’re not suggesting Platelet-Rich Plasma to your patients. Because Platelet-Rich Plasma has the highest adoption rate in this field – and for a reason. It has become indispensable.

The second group of people who uses PRP is aesthetic professionals followed by ophthalmic surgeons.

We’ll let some of the stories from Physicians themselves convince you about offering Platelet-Rich Plasma.

Here’s one physician who saw the value in Platelet-Rich Plasma ONLY when he himself was forced to seek the treatment.

“I am a physician who suffered with high hamstring tendinopathy which prevented me from playing competitive soccer and sprinting. I tried all conventional treatments for two years without any improvement. These included physiotherapy from a nationally recognized sports physio. I also used NSAIDs, fish oil/omega 3, glucosamine and chondroitin. I was looking at retiring from competitive sport. As a last resort I had two injections of PRP by a specialist sports physician. After three months I can now run without pain. This was a last ditch treatment that worked for me. (Although it was a trial of n=1).”

Six-Ways-Platelet-Rich-Plasma-PRP-Injections-Save-Money-For-Patients

Another dentist reports that he’s been using it for more than 8 years for grafting procedures.

PRP is very effective in bone grafting procedures with a huge amount of research supporting it’s effect in speeding healing. It’s use in tendonitis seems to be questionable. I am an oral & maxillofacial surgeon and have used it for greater than eight years with great success in my grafting procedures in the jaws.

The point is, we could go on and on and on about the reasons why a lot of physicians are excited about this treatment. It is simple and practical enough to quickly adopt it into your practice. And the risks are absolutely minimal.

Consider Getting Trained For Advanced Precision PRP Injections

That being said, you might want to undergo training for advanced prp injections at the Interventional Orthopedics foundation. Because, the ability to accurately localize the Platelet-Rich Plasma is one of the biggest needle movers when it comes to extracting the maximum therapeutic benefits. According to the foundation, only 1% of the physicians are able to do these precise injections without training. And so, chances are you may not have had the training. The Interventional Orthopedics Foundation also offer home study videos if you’re not able to attend in-person.

Six-Ways-Platelet-Rich-Plasma-PRP-Injections-Save-Money-For-Patients

And if you need help setting up your Platelet-Rich Plasma workbench, we’re here to help. Give us a call at (844) 377-7787 or drop us an email via hello@drprpusa.com. We handle everything from PRP kits to centrifuges to workspace for PRP and marketing brochures.

Platelet-Rich-Plasma-PRP-Injections-Debate
Why Are We Still Debating Platelet-Rich Plasma?

In the 2000s, when Platelet-Rich Plasma first started shifting its role from being a healing assistant in cardiac and orthodontic surgeries to the more leading role of healing bone grafts and joint tissues, many leading physicians claimed that the practitioners were putting profiteering before truth and science. They even said it was outright theft to charge $300 for an injection that, according to them, had an efficacy no less than placebo. That was in 2009 and the confusion back then was justifiable.

Fast forward 7 years later, in 2016, and we had the first FDA-Sanctioned, Randomized, Double-blind, Placebo-controlled Clinical Trial on Platelet-Rich Plasma for Knee Osteoarthritis which showed that PRP improved the outcome by 78% compared to 7% for placebo.

This was also confirmed by two Chinese major review studies this year, both Meta-analysis of Randomized Controlled Trials of Platelet-Rich Plasma for Knee Osteoarthritisfirst one here and the second one here.

Yet, we still see physicians here in the US – orthopedists and rheumatologists, among them – who don’t even bother to try it once on their patients!

What’s going on?

Platelet-Rich-Plasma-PRP-Injections-Debate

The Hidden Factor That’s Holding PRP Back

Platelet-Rich Plasma, as we know, contains 7X-9X concentration of platelets in a serum with a balanced ratio of plasma, leukocytes and RBC. This special mixture helps supply growth factors and other proteins that tissues can use to recruit stem cells and heal itself. This process is pretty straight-forward. Yet, we know for a fact that there are some physicians who fail to see results with Platelet-Rich Plasma, including some clinical studies performed by veterans.

Are they missing something?

We suspect it has got to do with the second part to PRP’s healing mechanism. It’s right application.

It can be summed up in the following two questions.

1. Precisely which tissue are you delivering the PRP to?
2. How are you making sure that the PRP is used by the tissues and not wasted?

This is where the science of Interventional Orthopedics come into play.

Platelet-Rich-Plasma-PRP-Injections-Debate

The Science Behind Interventional Orthopedics

On the outside, interventional orthopedics look very simple. You identify the area which needs healing, and then administer Platelet-Rich Plasma (or stem cells for that matter) to that particular area and wait for it to heal. Thinking that its this simple screws up the process for physicians who’re merely trying their luck with PRP. Because, the bulk of the Platelet-Rich Plasma treatment – the actual work that the physicians need to do – has to do with the following.

1) Identifying the exact group of tissues that are broken or degenerated (Accurate Localization),

2) Creating lesions in the damaged tissue, and

3) Delivering Platelet-Rich Plasma precisely at that location.

These advanced injections are much more effective and requires a different level of expertise.

For example, typical injections in the knee can only deliver the Platelet-Rich Plasma serum to the synovial fluid, synovial membrane and articular cartilage. The advanced injections like intraosseous infiltrations can deliver the PRP serum to the subchondral bone and the deep layers of cartilage that are affected by Osteoarthritis.

These kind of advanced injections require the use of fluoroscopic guidance for proper administration as well as proper training on the physician’s side.

Here’s one study that explains why accurate localization is linked with an improved clinical outcome Study of intra-articular infiltrations with intra-osseous injections of Platelet-Rich Plasma.

The thing is, not all physicians are trained to do it. The scope of these advanced injections are vast and warrant extensive training and expertise.

Platelet-Rich-Plasma-PRP-Injections-Debate

To continue with the example of the knee, most physicians are proficient only in the superomedial or anteromedial/anterolateral injections to the knee. However, advanced Platelet-Rich Plasma injections can deliver the PRP to precise locations like…

  • Medial collateral ligament (MCL)
  • Posterior cruciate ligament (PCL)
  • Anterior cruciate ligament (ACL)
  • Lateral collateral ligament (LCL)
  • Patellar ligament (PL)
  • Quadriceps tendon
  • Patellar tendon
  • Medial meniscus
  • Anteromedial joint line (AMJL)
  • Medial midpatellar (MMP)
  • Superomedial patellar (SMP)
  • Anterolateral joint line (ALJL)
  • Lateral midpatellar (LMP)
  • Superolateral patellar (SLP)
  • Lateral suprapatellar bursa (LSB)
  • Infrapatellar (IFP)
  • Lateral meniscus
  • Subchondral bone
  • Femur bone

Most physicians, instead of getting highly proficient in identifying and administering precise PRP injections, they get concerned over the relative lack of protocols for PRP Injections. They get carried away by details like the frequency of the injection, the leukocyte levels, and red blood cells, when the fact is… as long as you get the platelet concentration right (5X-9X baseline), the therapeutic effects are guaranteed. The frequency and the presence of Leukocytes are minor factors that have little to no impact on the outcome.

The most important factor is physician training for advanced injections under Ultrasound or Fluoroscopy.

If It Works For Knee Osteoarthritis, It Probably Works For Other Degenerative Diseases

There is another concern among some physician who claim that there’s no evidence for the particular condition that they’re treating. For example, let’s say they’re treating Spinal muscular atrophy in a patient and see that there has been no study that proves Platelet-Rich Plasma is a good candidate.

Does that mean it won’t work? Absolutely no.

It just means no one has ever studied it in detail. The working mechanism behind Platelet-Rich Plasma is so universal that if it works for the knees, it will work for the spine and other similar areas of the body as well. In fact, there is almost no part of the body that is not currently known to have a therapeutic effect upon application of Platelet-Rich Plasma – nerves, joints, muscles, skin, hair, and even the eyes are treated by PRP.

By the way, if you’re wondering if there really is a study on Platelet-Rich Plasma for Spinal Muscular Atrophy, here is one from Egyptian researchers.

Platelet-Rich-Plasma-PRP-Injections-Debate

Does Age Play A Role?

We’ve noticed that age does not have a correlation with the effectiveness of Platelet-Rich Plasma injections. It works just the same for the young and old.

However, the one thing that do have a correlation is the degree to which the disease has advanced.

The more advanced the disease, the less likely that Platelet-Rich Plasma can reverse its course. That is the reason why we recommend physicians treat Platelet-Rich Plasma as a first-line treatment for all possible conditions. It has already shown to be much more effective than both Cortisone and Hyaluronic Acid injections.

Platelet-Rich-Plasma-PRP-Injections-Debate

Education in Advanced regenerative-medicine injections

So, back to the single biggest needle-mover when it comes to Platelet-Rich Plasma injections: ACCURATE LOCALIZATION. This means the physicians must undergo advanced training for this type of injections.

And there are not many options available until recently.

Platelet-Rich-Plasma-PRP-Injections-Debate

Thankfully, we now have the Interventional Orthopedics Foundation (IOF) foundation – the first non-profit in the US dedicated to providing training for core injection skills. According to IOF, only 1% of the physicians in the US are trained to do these advanced injections. And chances are you may not have been trained.

With IOF, you can get trained for that in a real medical setting with skilled instructors and support staff.

According to the IOF website, they can train you on:

  • Injections for the healing of bone, tendon, ligaments, muscle or cartilage.
  • Accurate localization of these injections on damaged structures using image guidance.
  • New tools that facilitate percutaneous tissue manipulation.

This is a wonderful non-profit education initiative by Christopher J. Centeno, MD, Gregory Lutz, MD, Don Buford, MD and Richard D. Striano D.C., RMSK, all leading players in the regenerative medicine field.

Here’s a video you can watch to learn about IOF foundation.

And check out the IOF membership information here.

One last thing…

Platelet-Rich Plasma Standardization

As a Platelet-Rich Plasma practitioner, you’ll be out on the leading-edge. You’ll discover things that others may not be aware of. And you’ll have the opportunity to publish your findings. That’s when you’ll think of a standardization. By then, it’s too late. You’ve already performed a lot of injections and your data in unstandardized.

To avoid this, consider using a standard for the preparation of Platelet-Rich Plasma.

We suggest using the latest MARSPILL classification for Platelet-Rich Plasma developed jointly by Brazilian and US researchers.

The lack of standardization is the main culprit when it comes to debates over the efficacy of Platelet-Rich Plasma. We would love to see more and more researchers and everyday practitioners accepting a common standardized classification system for PRP.

Here’s the chart for the MARSPILL classification.

Platelet-Rich-Plasma-PRP-Injections-Debate

And you may also want to check out the DRPRP Kit for the most ideal concentration of Platelet-Rich Plasma.

Platelet-Rich-Plasma-PRP-Injections-Debate

Platelet-Rich-Plasma-PRP-Injections-Six-Reasons
Six Reasons To Offer Your Patients Platelet-Rich Plasma

For most musculoskeletal issues, the effects of immunosuppressants, steroids, DMARDs and protein-blocking drugs, never good to start with, usually wanes off after repeated use. And when it does, the patients realize that during the time the symptoms were being masked by these drugs, the disease was actually progressing at a steady pace. By this time though, it may already be in an advanced stage. That’s why more and more patients today are opting for natural biologics like Platelet-Rich Plasma at the earliest possible instead of waiting till all options are exhausted. This is the Self-Healing revolution.

And it’s just getting started.

Platelet-Rich-Plasma-PRP-Injections-Six-Reasons

The revolution, which some doctors call “the anabolic era of medicine,” has already eliminated the need for certain traditional methods of disease-intervention like invasive joint replacement surgeries and harmful drugs for hundreds of thousands of patients. Here are some very recent patient testimonials so you can get an idea.

Catherine was diagnosed with a rotator cuff problem about 2 years ago and had trouble lifting her arm. After just two PRP injections she’s now feeling really really great. See the video below for more.

George was suffering from Plantar Fascitis which was curtailing his otherwise active lifestyle. He took a year to rehab and tried a couple of other treatments before being referred to this particular doctor for PRP injections. And again, after just two PRP Injections, the pain he’s been suffering for a year was gone.

This is another amazing story. Bodybuilder Greg had suffered a complete tear in his muscle and tendon – doctors told him his condition is untreatable and that he’d have to live with a physical deformation for the rest of his life. After two and a half months and zero progress, he decided to try Platelet-Rich Plasma. Within 16 days, it had healed and today his muscle is 100% back to normal and he’s doing training.

Platelet-Rich-Plasma-PRP-Injections-Six-Reasons

Hear what he says in the video below.

Although, I am not in anyway claiming that Platelet-Rich Plasma Injection works for everyone, I do believe that almost everyone with a musculoskeletal issue is an excellent candidate for it.

Platelet-Rich-Plasma-PRP-Injections-Six-Reasons

Most physicians that we talk to (see our clients list here) say they see a success rate upwards of 80% in the chapter with PRP treatments regardless of the condition they treat. In this classic book about PRP, Dr. Bittencourt et al say, in 203 cases they studied including “38 epicondylitis, 45 Achilles tendonitis, 25 patellar tendonitis, 12 hamstring origin (ischial tuberosity) tendonitis, 08 plantar fasciitis, 08 flexor carpi ulnarii tendonitis, 07 pes anserinus tendonitis, 04 biceps femoris tendonitis, 03 iliopsoas tendonitis, 06 athletic pubalgias and 06 biceps brachii tendonitis,” they saw success rates in excess of 75%.

Platelet-Rich-Plasma-PRP-Injections-Six-Reasons

It’s amazing how they’re utilizing PRP Injection’s therapeutic effects across the board whether its orthopedic healing, wound management, hair regeneration, facial rejuvenation or pain-reduction. NIH says PRP works by “promoting better collagen I deposition, decreased cellularity, less vascularity, and higher glycosaminoglycan content,” whatever that may mean.

That’s why we’re seeing record growth in the Platelet-Rich Plasma market.

It has long ceased being a fad that only a group of sports medicine specialists promote because pro-athletes like Pittsburgh Steeler wide receiver Hines Ward had used it with remarkable success. And certainly has moved beyond the realm of boutique clinics. Instead, thousands of clinics all over the nation are now offering it. It is the wave of the future, still in its early-phase of saturation. And you can be one of the pioneers in the field.

Platelet-Rich-Plasma-PRP-Injections-Six-Reasons

Here are six reasons why you should start offering Platelet-Rich Plasma for your patients today.

1. Clear and Obvious Results

There would be no point in discussing a treatment if it doesn’t deliver results. You only need to look at ONE SOLID STUDY LIKE THIS to conclude its efficacy because the way Platelet-Rich Plasma works is not unique to conditions treated. Meaning, if it works for tennis elbow, chances are, it will work for achilles heel too. As well as chronic wounds, spine disc regeneration, bone healing, tendinopathy and much more.

That is to say, the science behind Platelet-Rich Plasma is solid. The growth factors within platelets, mainly platelet-derived growth factor (PDGF), basic fibroblast growth factor (bFGF), transforming growth factor β (TGFβ) and vascular endothelial growth factor (VEGF) have been found again and again to be agents capable of healing tissues. PRP was initially tested by dentists in the 1990s for repair of bones after oral surgeries. Since then scores of the physicians have used it to treat the following with excellent success rates.

  • Rotator cuff injuries (study here)
  • Tennis & golfer’s elbow (study here)
  • Hamstring, hip, knee and ankle strains and sprains (study here)
  • Achilles tendinosis & plantar fasciitis (study here)
  • Knee, hip, and other joint osteoarthritis (study here)
  • Degenerative disc disease of the spine (study here)
  • Nerve injury and neurological pain (study here)
  • Chronic ulcers and post-surgical wound healing (study here)
  • Burns, skin grafts, and scar tissue remodeling (study here)

Yes, physicians have successfully used PRP to treat these conditions for OVER A DECADE now. Yet, there are some physicians who’re only now starting to see the possibilities of this autologous healing agent. They’ve been very dismissive about it until now thanks in part due to the healthcare industry’s lackadaisical approach to it.

Fortunately, much of that is changing. The future is looking bright for Platelet-Rich Plasma. A quick search in clinical trials database reveals 101 clinical trials at the time of this writing.

And it has now become a powerful force in modern medicine.

2. Simple outpatient procedure – zero down time

Preparation of Platelet-Rich Plasma is a procedure that puts the latest high-technology protein-blocking drugs to shame (more on that later) in every sense. Prepared using a simple desktop centrifuge in about 10 minutes (not including the time to draw blood), PRP delivers more therapeutic benefits than many other billion dollar drugs used for the same purpose. The entire procedure takes a maximum of 45 minutes and patients can return to their usual daily routine immediately. Plus the produced PRP is capable of remaining sterile and viable for a couple of hours.

And the safety record? Excellent, in all its use cases.

This may be one of the reasons why patients keep coming back for more once they’ve had an initial injection. The more the better they say. (We don’t agree with them though.)

3. Eliminates invasive surgeries in the long run

Platelet-Rich Plasma acts on the body in the most natural way you can think of – by triggering a healing cascade consisting of hemostasis, inflammation and proliferation phases. This is the way our bodies are designed to heal. It doesn’t aggravate the disease by blocking the natural function of cells, which is what almost all other drugs are designed to do. Therefore the earlier your patients have Platelet-Rich Plasma injections, the less likely that things will get complicated enough to warrant a surgery. We’ve heard from doctors again and again that their patients who were prescribed surgery ended up not having surgery for years.

Platelet-Rich Plasma can actually regenerate tissues, muscles, ligaments and even bones. It works like stem cells but with little less dramatic results and none of the side-effects that stem cell treatments are notorious for.

Platelet-Rich-Plasma-PRP-Injections-Six-Reasons

Here’s what one of the doctors had to say.

4. The Age Of Ortho-Biologics Is Here – There’s No Escape

One of the biggest reasons why physicians don’t start offering Platelet-Rich Plasma sooner is that they mistakenly think that PRP is just a fad and it might vanish entirely a few years later. But the fact is, the biologic era of medicine is here. And Platelet-Rich Plasma is leading it. And in coming years, putting together joints and discs using steel may look primitive as more scientific data emerge in favor of Platelet-Rich Plasma. Some experts suggest that injection therapies may replace up to 70% to 80% of the surgeries in the near future.

In other words, this shift in treatment paradigm is big.

The earlier you get in, the more expertise you gain. There is a reason why some doctors get amazing results with PRP while others struggle to make it work. The reason is clear. The ones that make it work have a thorough understanding of the science behind it, and are confident about the limits and potential of the treatment. In this case, there is no substitute for experience. The sooner you start doing them, the more confident you become in PRP injection therapy. Don’t wait.

Platelet-Rich-Plasma-PRP-Injections-Six-Reasons

5. No Risk Of Side Effects Or Mutagenic Effects

One of the biggest drawbacks blocking the stem cell treatments from going mainstream is the potential for the treatments to go horribly wrong. Since Platelet-Rich Plasma acts on cells via transmembrane signal cascades and doesn’t modulate the cells and their functions, there can potentially be no harmful effects from using it. That’s why you DON’T NEED FDA approval to start offering Platelet-Rich Plasma treatments.

It also means that aside from occasional patient dissatisfaction with PRP – could happen in less than 10% of the cases – there is nothing else you need to worry about. No further complications, regulatory actions, or lawsuits can arise. If it doesn’t work, fine. You can try some other treatments. Or you can even combine it with other injection treatments, provided the combination does’t negate the effects of PRP – we’re seeing a trend towards that as evidenced by this study where the therapeutic effects were doubled when PRP was added to the treatment.

That’s why your decision to start offering PRP is going to be an easy one.

Platelet-Rich-Plasma-PRP-Injections-Six-Reasons

6. Low Cost Of Entry And Lower Costs For Patients

As I mentioned earlier, a very low investment in a simple desktop centrifuge like this and the PRP Kit will get you up and going with PRP injection treatments.

And you don’t have to worry about stocking up on expensive drugs or other raw materials. Your cost of goods sold is very low. That can translate to lower costs for the patient.

Platelet-Rich-Plasma-PRP-Injections-Six-Reasons

But, I’m not suggesting that it will be all a smooth ride with Platelet-Rich Plasma. One of the challenges you may face is generating standardized protocols for different patient use cases. This can take a while due to trial and error – a fact evident in the current literature, where different studies follow slightly different protocols resulting in varied outcome.

So you have to use your expertise in developing protocols to maximize your results. Some factors that may come into play are the activation method, presence of red blood cells, number of spins in centrifuge, proficiency in ultrasonic image guidance, number of leukocytes and photo-activation of PRP.

You may also have to test things like Platelet-Rich Fibrin Matrix depending on your therapeutic needs.

Webinar: Intradiscal Platelet-Rich Plasma Injections

Dr. Gregory Lutz is one of the early pioneers in Platelet-Rich Plasma – he is the author of a prospective, double-blind, randomized controlled study on lumbar intradiskal PRP injections. And here in the video below, Dr. Lutz discusses his experience and provides case examples for PRP treatments.

PRP Vs The Latest FDA-approved $1 Billion Arthritis Drug

This past May(2017), the FDA approved a drug known as Kevzara – an interleukin-6 receptor (IL-6R) blocker. According to the reports, this drug costs patients (or their insurance providers) $39,000 a year and is expected to generate upwards of $1 billion in revenue for the licensing company by the year 2023. This is a drug that offers at best a temporary 66% improvement in signs and symptoms when using with another DMARD – and carries a risk of producing serious immunological disorders as the drug affects the immune system.

Now, in contrast, the autologous, non-immunogenic Platelet-Rich Plasma needs only a couple of injections that has no side effects – all of it produced from a little desktop centrifuge at your local office. No patent licensing fees involved. Sure, the patient has to pay a couple hundred bucks out of pocket, but which one do you think an informed patient will choose?

Come join the revolution by getting started with Platelet-Rich Plasma. Click here or call us at (844) 377-7787 to talk to us. We’ll support you in the setup and marketing of PRP.

Platelet-Rich-Plasma-PRP-Injections-Six-Reasons

Three PRP Treatments Revolutionizing Skincare
Three PRP Treatments That Are Revolutionizing Skincare

While there are thousands of skincare centers nationwide offering at least one PRP treatment for their customers, most of them doesn’t go beyond the PRP Micro-needling treatment popularized by Kim Kardashian. The reason is – it is the simplest of all Platelet-Rich Plasma aesthetic treatments around and also the most sought-after treatment. This is all good until they realize the immense potential of PRP treatments. What they’re missing out on is the fact that once you’ve made the investment for Platelet-Rich Plasma which includes a centrifuge, PRP kits and staff training, they can start offering a whole suite of treatments for their clients.

Three PRP Treatments Revolutionizing Skincare

Platelet-Rich Plasma’s Quiet Revolution In The Skincare World

One great thing about PRP treatments is that the protocol for obtaining high quality Platelet-Rich Plasma is the same regardless of its application. Whether its joint injuries, osteoarthritis, bone healing, spinal disc regeneration or skin rejuvenation, the process is the same: draw up to 20cc blood from the patient, place it into the centrifuge which concentrates the platelets and then draw out the Platelet-Rich Plasma for immediate application. This simple process coupled with PRP’s vast scope of healing makes it one of the most significant advances in modern medicine. In fact, one physician, Dr. Lewis Maharam M.D. aka The Running Doc, who regularly writes for New York Daily News calls it “the greatest innovation since the invention of MRI.”

That applies to skincare as well. The Platelet-Rich Plasma you obtain from your clients can be used for a number of treatments, the demand for which are only growing. Here are a few ideas – these are probably the most popular/cutting-edge PRP treatments performed by dermatologists and plastic surgeons.

1. Facial Skin Augmentation With Fillers

The topical application of Platelet-Rich Plasma with Micro-needling can help regenerate the degrading skin cells and promote collagen production to keep skin plump and supple. This basic process may be enough for some of your clients. But those who’re looking for more than just skin rejuvenation, you may have to go deeper. To augment the face with natural, feminine volume, you’re going to have to inject Platelet-Rich Plasma deeper into the dermis. This will supply the growth factors to the degraded dermal tissues under the surface.

For volume though, you’ll need a filler. You can either go for a Platelet-Poor Plasma (PPP) based filler (PPP is the left-over from the Platelet-Rich Plasma process – you can read about the process in detail here.) or you can use any Hyaluronic Acid filler like Restylane Lyft.

This combination injection treatment has been proven to work well. One study by Dr. Daniel Sister analyzes the effect of a combination of platelet rich plasma, hyaluronic acid, and succinic acid for facial augmentation. The treatment showed 100% success rate.

The combination treatment seems to be evolving into a new standard in facial augmentation. It’s definitely seeing growing demand.

Three PRP Treatments Revolutionizing Skincare

2. RePigmentation And Vitiligo Correction With CO2 Laser

Companies spend millions of dollars on research to turn defective cells healthy and to increase the skin’s collagen production. They are looking into DNA technology to pull this off. But adding Platelet-Rich Plasma to existing treatment methods may be a simple and effective way to achieve the same results. Scientists from Cairo, Egypt had recently proven that adding PRP injections to fractional CO2 laser treatment for correcting vitiligo can boost the results by 4X compared to just using the laser alone. This is great news because given that CO2 laser can also be used to treat facial wrinkles, age spots, and acne scars, it seems we can significantly boost the results by combining it with PRP injections.

And if PRP is capable of boosting the effects of CO2 lasers, chances are, it can do the same for some of the other facial resurfacing treatments that you already offer your clients. Isn’t that an amazing opportunity… to offer the same treatments you’ve been administering for years – but only this time it’s significantly more effective with a secret biologic hack? Hundreds of skincare clinics are just doing that. It’s time to get on the bandwagon and start surprising your clients.

Three PRP Treatments Revolutionizing Skincare

As one of our friend-clinic owner says, PRP treatments have been a big boon to the business (PRP treatment has a 100% “worth it” rating on real self) as even people who’d had total skin resurfacing have responded well with it.

3. Hair Rejuvenation With Auto-injection

Mesotherapy is a well-known treatment that uses painless micro-injections for delivering active ingredients evenly to skin surface. This novel procedure has a reputation for improving the quality results obtained by traditional skin rejuvenation substances like vitamins and peptides. And as many skincare clinics have discovered, there could never have been a more synergistic technology than this for Platelet-Rich Plasma. The Meso Gun, as we call it, can be used to deliver an even amount of Platelet-Rich Plasma to the face, neck, chest, and hands for rejuvenation and reduction of wrinkles and discoloration, to thighs and tummy for treatment of cellulite and stretch marks, and to the scalp for the treatment of hair loss.

The big winner from this pairing of technologies is the hair loss treatment. Platelet-Rich Plasma when administered on the scalp using Mesotherapy works as an “elixir for hair growth” – and here’s a recent peer-reviewed study on Stemcell investigation journal that confirms this. Hair loss treatment is one of the examples where PRP treatment has exceeded the expectations set by the industry.

That’s why we believe this is one of the treatments that every skincare clinic should offer. Hair-loss and thinning of hair affects both men and women and is one of the most popular cause of worry for your clients. It complements the skincare treatments you offer and you’ll see many of your clients thanking you for that.

Contact us at (844) 377-7787 for more information on the Mesotherapy gun.

If You’ve Never Heard Of These PRP Treatments

Some of these treatments are so new – you may have never heard of them before. And that’s a sign that you should offer them immediately. If you have joined the Platelet-Rich Plasma bandwagon, it’s only intuitive to expand your offerings from just a PRP-micro-needling treatment to these in-demand procedures. You can do this with very little changes, if any, to your existing Platelet-Rich Plasma setup. And chances are they will pair well with other treatments you offer whether it’s Kybella injections, Photo laser treatments or dermal fillers.

And if you aren’t offering Platelet-Rich Plasma yet, this post illustrates a whole lot of reasons why you should be. The demand is only getting stronger. The earlier you join, the more you’re likely to prosper from this incredible breakthrough of modern medical science.

Three PRP Treatments Revolutionizing Skincare

Are You Maximizing Your Clinic’s Potential With PRP?

If you’re getting started right now, give us a call at (844) 377-7787 or head on to our shop to setup your clinic with the right things for Platelet-Rich Plasma. Our proprietary PRP kit makes the Platelet-Rich Plasma extraction process super efficient and produces high quality PRP in far less time than it would take otherwise. You can read more about our PRP Kits here.

Platelet-Rich Plasma is the blockchain of self-healing and it’s here to stay. It will become best friends with almost every aging man and woman either through their need to reverse aging effects or the need to heal musculoskeletal issues. And both group of people will start putting trust in it once they’ve had a chance to try it. That’s why demand for PRP has skyrocketed organically – without the big pharma advertising dollars – over the past few years.

The question is, are you willing to seize its potential?

Ovarian-Rejuvenation-Platelet-Rich-Plasma-PRP-Injections
This Company Reverses Menopause With PRP Injections

Infertility doesn’t just affect a woman’s capacity to give birth. It also crushes her hormone levels and her emotional ecosystem. So when you hear the statistics that say one in eight women are clinically infertile, that’s a big hole in society as a whole. The lack of simple treatments for fertility correction hasn’t helped the situation either. But that may just change in the near future. Right now, one company is conducting a clinical trial to prove how simple it can be to regenerate ovaries and even reverse menopause. All it takes is a Platelet-Rich Plasma Injection directly into the ovaries. The results from this trial could change the lives of thousands of women worldwide.

Validation of An Idea Whose Time Has Come

Although menopause and infertility are two separate issues altogether, they’re both a function of a healthy ovary. The healthier the ovary, the less chances of menopause and infertility. Platelet-Rich Plasma has long proven it’s chops as a basic regeneration material capable of restoring tissues to its healthy state. So if the simple PRP injections can restore hair follicles, manage wounds, heal ligaments, repair joints, restore spinal discs and even regenerate bones, can it also be used to rejuvenate women’s ovaries? We have to thank researchers in Greece who’d popularized this novel idea starting in 2015.

Ovarian-Rejuvenation-Platelet-Rich-Plasma-PRP-Injections

It All Started In 2006

Traditionally, women are thought to have born with a fixed number of eggs. And for long, the scientists believed that the “natural” course would be for the eggs to get depleted over time causing women to start producing lower and lower quantities of estrogen, the primary female sex hormone. Once the eggs are depleted, they enter menopause and lose their ability to conceive. But a study in 2006 shattered this paradigm. It revealed an interesting phenomenon in female mice where the mice continued producing eggs long after menopause. The key idea this research put forth was that infertility was not a function of “running out of eggs.” Instead, it’s a direct consequence of an ovary which had become unhealthy.

That opened up possibilities in the mind of Dr. Jonathan Tilly, who had conducted the research on female mice, and he became determined to find a way to “revive” ovaries. Then one fine day, he heard of a research where women who’d received bone-marrow transplants mysteriously had regained their fertility. The rest as they say is history.

Ovarian-Rejuvenation-Platelet-Rich-Plasma-PRP-Injections

The Power Of Growth Factors

It didn’t take long for Dr. Tilly to discover that it was the growth factors in bone marrow that was rejuvenating the ovaries –
the same growth factors that were available in Platelet-Rich Plasma. But for some strange reason, he did not follow up on that route with ovarian rejuvenation. His company, OvaScience, instead pursued its EggPC IVF method called Augment – which is a super complex process of producing healthy eggs with the aid of mitochondria taken from EggPC cells. The procedure has not been a big success and they have since been focussing on other treatments since.

Fast forward to 2015 and there was a Chinese study that established that Platelet-Rich Plasma can indeed rejuvenate ovaries. They demonstrated it on five women with thin uterine linings all of whom were able to conceive babies after a treatment based on the intrauterine infusion of PRP. At about the same time, a Greek fertility clinic began testing this idea much more aggressively and found that rejuvenating ovaries with Platelet-Rich Plasma worked for both women in various stages of menopause as well as those who had uterine complications. They began testing the effects of trans-vaginal ultrasound guided PRP injection into the ovaries of women. The primary researcher behind it is Kostantinos Pantos and he and his team had injected Platelet-Rich Plasma for over 180 women between 34 and 51 years of age and the results have been promising.

“Success In Two-Thirds Of Cases”

According to Dr. Pantos, in about two-thirds of the cases, he’s able to identify changes in hormonal patterns, reactivation of menses and egg production. He says, “Women who have been in menopause, whose ovaries aren’t working, who’ve ceased to produce follicles — they’re ovulating.” Once the women start ovulating, Dr. Pantos then sends them to an In Vitro Fertilization (IVF) center for artificial insemination.

Dr. Pantos and his colleague Dr. Sfakianoudis talks about their patient, a 39-year-old from the Netherlands, who had been slowly entering Menopause and had not had a period in four years. She began menstruating again just a month after the PRP injections to her ovaries. ONE MONTH LATER!

In another case, they reversed menopause in a 45-year-old woman who’d been in menopause for 5 years since the age of 40 with just a simple PRP injection on her ovaries.

After several such cases, the greek doctors became convinced that the same essence of Platelet-Rich Plasma which is capable of regenerating damaged skin, muscles, and bones can also regenerate the ovary.

Back home in New York, the famous fertility clinic headed by Dr. Hugh Melnick, also started offering the ovarian Platelet-Rich Plasma treatment.

Ovarian-Rejuvenation-Platelet-Rich-Plasma-PRP-Injections

“An Astounding 75% Success Rate In Pre-Clinical Trial”

The discovery of the Greek clinic and its adoption by Dr Melnick, caught the attention of the fertility researcher Dr. E. Scott Sills, who after investigation, became convinced that the treatment holds tremendous potential. Here’s a video of Dr. Sills on The Doctors Show telling the audience why he believes in the treatment.

Dr. Sills then partnered with the Greek clinic to initiate the long process of clinical trials. Pre-clinical studies conducted in late 2015 showed that the treatment was successful in 45 out of 60 women – an astounding 75% success rate and the women were between 45 and 64 years of age.

Their success meant that they could initiate a full clinical trial and found a sponsor – a biomedical company named Ascendance Biomedical headed by Aaron Traywick. Their goal is to publish a peer-reviewed journal. And they got two well-known Berkeley scientists Michael and Irina Conboy to be the advisors for the project. The trials will be headed by Dr. Sills at his Carlsbad, CA based fertility research center, Center for Advanced Genetics.

Ovarian-Rejuvenation-Platelet-Rich-Plasma-PRP-Injections

Innovium – The World’s First Pilot Trials In Ovarian Rejuvenation

Dr. Sills’ clinical trial, named Innovium, is the world’s first pilot trials in “Ovarian Rejuvenation” using Platelet-Rich Plasma and is limited to just 50 women who’re in menopause and have had at least one failed IVF cycle.  Participants will undergo inter-vaginal ultrasound guided PRP Injections in both of their ovaries and are required to commit to a full IVF session at the facility. By controlling both the Ovarian Rejuvenation therapy and the IVF, Dr. Sills hopes to increase the success rates dramatically.

Managing Director Aaron Traywick has another interesting take on their clinical trials. He says:

“The goal of the trial is not to prove that we can reverse menopause, because over and over again in our treatments, we know that this is the result. We also know that the treatment triggers a whole body response that restores hormones to the levels of youth. Now, we want to see if the rejuvenation is a permanent one, and if we have discovered a connection between the loss of fertility and the damaging effects of aging in the body.”

So the big picture here is the possibility that Platelet-Rich Plasma Injections can reverse the effects of aging. Very promising.

Ovarian-Rejuvenation-Platelet-Rich-Plasma-PRP-Injections

Restores Hormone Levels To The Levels Of Youth

One of the secondary effects of Ovarian Platelet-Rich Plasma treatments is the change in Hormone levels. Dr. Pantos notes that in those women who had a successful outcome, their hormone levels returned to the level of their youth. According to the Innovium team, during the pre-clinical trial on 60 women, the hormones – Luteinizing Hormone (LH), Follicle-Stimulating Hormone (FSH), Estrogen, and Anti-Mullerian Hormone (AMH) – had returned to youthful levels in all 45 patients for whom the treatment was successful.

This is kinda big deal because it means it’s not just about restoring fertility – Ovarian Platelet-Rich Plasma injections can eliminate or reduce the mood swings, memory loss, lack of focus, irritability, weariness, hot flashes, night sweats, stress, anxiety and depression associated with Menopause. Plus, it can also restore the the water-holding ability and elasticity of the skin. Few can argue that this isn’t a remarkable development in modern medicine.

Ovarian-Rejuvenation-Platelet-Rich-Plasma-PRP-Injections

Significantly Cheaper Than Existing Methods

What’s even more amazing is the fact that Ovarian Platelet-Rich Plasma Injections are relatively cheap compared to other Stemcell-based and mitochondria-supplementing methods which goes for upwards of $24,000, even some going for more than $34,000. At the time of writing, Dr. Hugh Melnick’s clinic charges only $4000 for the treatment and we believe the price will be substantially more cheaper as more and more physicians start offering it. Therefore the outcome of this clinical trial may well redefine the future of Platelet-Rich Plasma and we could not be more excited. That’s why we encourage our physicians friends to get on board as soon as possible so they can contribute to the development of this novel procedure.

Ovarian-Rejuvenation-Platelet-Rich-Plasma-PRP-Injections

Another Trial By University of California San Francisco

This isn’t the only clinical trial either. There is another one by UCSF where they are attempting to validate the results of intrauterine Platelet-Rich Plasma injections for overcoming Asherman’s Syndrome and thin endometrial lining. Although the study does not deal with Menopause, it’s a vote of confidence for PRP Injection’s ability to rejuvenate ovarian tissues.

Get On The Bandwagon

The future of Platelet-Rich Plasma is only looking brighter. Right now, with all these wonderful research going on, those who sit on the sidelines refusing to enter the field and start scoring with Platelet-Rich Plasma are going to miss out. But for those believers, there couldn’t be any time more perfect than now. You could be one of the pioneers of this treatment – and who knows, perhaps you’ll be discovering new uses of PRP Injections. This is a treatment which is defined by its simplicity and low set up cost. All you need is a centrifuge and a PRP Kit. Start offering Platelet-Rich Plasma treatments today. And yours could be one of those pioneering medical centers in this field.

Platelet-Rich Plasma-PRP-Injections-Changing-Arthritis-Treatments
How Platelet-Rich Plasma Is Changing Arthritis Treatments

From a mere 6% in 1940, the rate of knee arthritis in our nation has jumped to almost 16% to become one of the top causes of disability. The consequences are paramount as arthritis doesn’t just affect knees – it overpowers people with fatigue, pain, depression and even difficulty getting out of bed. Over the past few years, Platelet-Rich Plasma has quietly emerged as a
savior for many of these patients. It ushered in the anabolic era of treating Arthritis.

Of course, this coincides with Platelet-Rich Plasma’s skyrocketing adoption rate and it’s media popularity. In fact, it has become so popular that, there is even a research paper about it’s popularity!

Platelet-Rich Plasma-PRP-Injections-Changing-Arthritis-Treatments

How Platelet-Rich Plasma Is Changing Arthritis Treatments

Traditionally, the only road available for chronic knee arthritis patients was the road to total knee replacement. It will start out with the administration of corticosteroid injections. After going through that for quite a bit, the patient will show no further progress and the surgeon would suggest knee arthroscopy for debridement of affected tissues. That would feel better for a while before the patient returns for more. The surgeon would then give them a date for total knee replacement.

All of that has changed with Platelet-Rich Plasma and Stem cell treatments. Now, we have found out that the best bet we have is to administer Platelet-Rich Plasma at the earliest stages of knee arthritis to regenerate the affected tissues as soon as possible. Platelet-Rich Plasma, with its growth factors and cytokines, not only relieves the symptoms but it is proven to reverse the condition as time goes by. It creates a very beneficial, positive cellular change in the joint pathology.

Platelet-Rich Plasma-PRP-Injections-Changing-Arthritis-Treatments

All of that without the adverse effects of an invasive surgery.

Proven Regeneration Tool Abandoned By The Big Pharma

Right now, Platelet-Rich Plasma is used for a number of musculoskeletal conditions like Rotator cuff injuries, Tennis and golfer’s elbow, Ligament strains, Knee instability, Chronic back pain, Knee and Achilles tendonitis and more. There is no adverse effects or long term implications. Few other treatments can match this record. The important distinction to be made when comparing Platelet-Rich Plasma with other existing treatments is its regeneration potential. Injecting PRP doesn’t just correct the condition – it has the potential to make it a little better than before. As far as research is concerned, most of the PRP literature concerns around knee osteoarthritis. Here’s a Level 4 systematic review and a more recent Level 1 systematic review of 10 studies with a total of 1069 patients if you want to verify the results.

Of course, it doesn’t mean all you need is a couple of PRP Injections and things will be better. Or maybe that’s it?

If the big pharma is able to package this and market, they would’ve carved out a multi-billion dollar market by now. But they can’t because the primary raw material – blood – has to be autologous and fresh for this to work efficiently. Some researchers are exploring the possibility of freeze-drying Platelet-Rich Plasma. This may or may not work depending on how well it can preserve the key elements of Platelet-Rich Plasma – the bioactive proteins in the platelets, plasma and white blood cells.

According to Bert Mandelbaum, MD, DHL (Hon), Chairman of Santa Monica Orthopaedic & Sports Medicine Foundation and Co-Chair of Medical Affairs at the Institute of Sports Sciences, Cedars-Sinai, Platelet-Rich Plasma is more promising than stem cells. See his recent article in Medscape here.

Platelet-Rich Plasma-PRP-Injections-Changing-Arthritis-Treatments

Still there are plenty of doctors who comes to us asking, “Where is the research? The FDA-cleared prospective, multi-center, sham-controlled, randomized, double-blind clinical trials?” Actually, the FDA is hard at work clearing devices that provide relief of pain and symptoms associated with knee osteoarthritis (OA) for up to 90 days by nitro-freezing the nerves!

Many Research, Many Doctors

The amount of research from independent research institutes around the world on Platelet-Rich Plasma is just a tad bit overwhelming. New findings are published almost every month on the topic. The vast number of research mirrors the immense potential of PRP Injections. And for knee osteoarthritis, there is already unquestionable proof.

Platelet-Rich Plasma-PRP-Injections-Changing-Arthritis-Treatments

Here are some of the advocates of Platelet-Rich Plasma:

  1. Caring Medical’s Ross Hauser, MD has written a well-researched article about Platelet-Rich Plasma for knee osteoarthritis here.
  2. Dr. Lewis G. Maharam, MD, FACSM, one of the world’s most extensively credentialed and well-known sports health experts known as Running Doc™, always show great enthusiasm when describing Platelet-Rich Plasma.
  3. Best selling author and team physician of Philadelphia 76ers, Dr. Nicholas DiNubile MD recently wrote an article saying Platelet-Rich Plasma may make knee-replacement surgeries a thing of the past.
  4. Famous Long Island physician Dr. David J. Weissberg, MD, says for his patients, with just one shot of PRP, in general, gets relief from their problems without any need for surgery and slow but progressive cure in their problems.
  5. Dr.Kevin F. Darr, M.D., a national leader in orthopedic medicine and a visionary in cell therapy, combines PRP with other cell therapies and finds the results “outstanding.” Dr. Darr is one of the fifteen physicians selected to participate
    in an FDA approved Level 1 clinical study utilizing cell therapy techniques. Here’s a recent testimonial from one of his patients.

Of course, there are many more. But for those who’re skeptical in trying Platelet-Rich Plasma or even offering them to their patients – a doctor once told me he’s skeptical because he might appear as a greedy physician to his patient if he offered unproven techniques for the sake of trying it – they can rest assured that many nationally reputed doctors are ardent fans of this therapy. Plus, there’s really no risk in trying it.

Platelet-Rich Plasma-PRP-Injections-Changing-Arthritis-Treatments

The Best Approach For Skeptical Doctors

We know many of your patients rely on medical insurance coverage for their osteoarthritis and other treatments. And many of them are pensioners. Asking them to pay out of their pockets for a treatment that you yourself have doubts in – that’s impossible. While we hope the insurance starts accepting it, we can’t just ignore the results. You’ve seen the research, and heard the testimonials and read the media pieces.

So instead of wondering whether it might work – why not give your patients a try. Give the first treatment for FREE. Yes, I’m suggesting you let your patients try it out for FREE.

From what we’ve seen so far, once patients clearly experience the healing results – they’ll come back for more and you’ll more than make up for the FREE treatment you provided them.

We’ve seen over and over again – in several clinics – that patients always come back for more.

Like this case from Dr. Payel Banik’s office. (Dr. Payel is the owner of Osteopathic Healing Hands, Houston, TX.) The patient in the video below explains why he’d come back for more.

Offer Your Patients A Free Platelet-Rich Plasma Injection

So what do think? Are you going to stand on the lines and watch until government regulatory boards mandate PRP for osteoarthritis and other conditions? Or are you going to start helping your patients right now? Start offering it for FREE so that YOU will be convinced that it works. And win over your patients in the process. And watch them come back for more.

The choice is yours.

If you’re seeing a lot of patients with intermediate to advanced stages of osteoarthritis or other similar musculoskeletal conditions, offer them a FREE Platelet-Rich Plasma injection starting today. We’re very confident that it will make the fall in love with this treatment for life! There will be plenty of referrals for you.

All you need is a PRP Kit and a compatible centrifuge and you’re good to go. Call us at (844) 377-7787 if you need more info.

Platelet-Rich Plasma-PRP-Injections-Changing-Arthritis-Treatments

Orthopedic-Surgeons-Guide-Platelet-Rich-Plasma-Injections
The Orthopedic Surgeons Guide To Platelet-Rich Plasma

According to the famous sports medicine expert, Brian J. Cole, M.D., M.B.A., a good orthopedic surgeon is one who works hard to prevent his/her patients from going under the scalpel. To this end, he advocates a lot of contemporary thinking and treatments like Platelet-Rich Plasma rather than the usual MRI-driven surgical procedures. And we’re seeing more and more orthopedic surgeons who are following the cues of the people like Dr. Cole and are genuinely astounded by the sheer number of surgeries they could avoid by a little poking around with alternative treatments.

“The art of medicine consists of amusing the patient while nature cures the disease.”
~Voltaire

Orthopedic-Surgeons-Guide-Platelet-Rich-Plasma-Injections

A Little Late to The Regenerative Game?

Generally speaking, orthopedic specialists have been hesitant in adopting regenerative therapies. They’ve been relying on visual technologies like MRI machines a tad bit too much and hence accustomed to “seeing” in order to believe it. But regenerative therapies like Platelet-Rich Plasma doesn’t work that way. One has to believe in it to see the results. You can’t half-heartedly try PRP injections and give up if it doesn’t work. In our opinion, that’s what separates a passionate orthopedic surgeon from a “just doing my job” orthopedic surgeon. The former has a lot of belief in the rather invisible but non-surgical options. As the saying goes, “All surgeons know how to operate, a good surgeon knows when to operate, but a great surgeon knows when not to operate.”

Orthopedic-Surgeons-Guide-Platelet-Rich-Plasma-Injections

And no doubt, one of the key treatment options in Orthopedics that ends up actually saving a lot of patients from going under the knife (and has since become a powerful force in medicine) is Platelet-Rich Plasma. Of course, we’re biased but there is probably no other medical discovery in the modern medical history that has as much an impact on the medical industry as Platelet-Rich Plasma. Physicians now prescribe it as first-line treatment for a variety of medical conditions. And although Plastic surgeons are leading the way in pioneering its application, we believe the nature of PRP is such that it will eventually be of massive benefit in Orthopedics than any other field.

Another reason is runners. They constitute a good portion of the orthopedic surgeon’s patients. These patients do not have life-threateningly serious conditions. They might have minor pain or discomfort that prevents them from enjoying their daily run. They just want to be able to run again. The great news is, a single shot of Platelet-Rich Plasma can do wonders for them.

Orthopedic-Surgeons-Guide-Platelet-Rich-Plasma-Injections

Evidence-Based PRP Treatments In Orthopedics

Although few physicians question the efficacy of Platelet-Rich Plasma for joint diseases like knee arthritis, there are well-meaning physicians who resist recommending it to their patients lest they end up wasting the patient’s money. We regularly receive enquiries from such physicians asking for “hard evidence” of PRP’s efficacy. We know that skepticism is natural. And that’s why we’re doing our best to educate physicians so they can come to their own conclusion about Platelet-Rich Plasma.

The truth is there has been more evidence than we can handle.

Let’s take a look at a few of them.

Arthritis

Platelet-Rich Plasma is huge in arthritis. Earlier this year, researchers from Shanghai, China published a review of the 14 existing randomized controlled trials related to PRP treatment of knee-OA that comprised a total of 1423 participants. And they concluded that Platelet-Rich Plasma could be more efficacious than HA, ozone, and corticosteroids in terms of pain relief and functional improvement at 3, 6 and 12 months follow-up. This justifies why some physicians are confident enough to use PRP injections as first-line treatments for all osteoarthritis cases.

Orthopedic-Surgeons-Guide-Platelet-Rich-Plasma-Injections

And just recently, Spanish researchers took the next step. They tested an advanced method of Platelet-Rich Plasma infiltration for treating severe hip osteoarthritis and found that the technique extended the distribution of PRP and improved its efficacy. Simultaneously, another Spanish study established that a single PRP injection can be effective in treating late-stage knee OA. This is really really great news. Because if you’re physician dealing with arthritis patients, you probably have never seen any treatment that is this simple which has long-term therapeutic effects like that.

However, on the standardization of the PRP treatment itself, there has been no major progress except that most of the research agrees that a concentration of 1,000,000 platelets per µl (or 5X-7X above baseline) is required for therapeutic effect. This can be obtained through buffy-coat based double-spin process similar to the one followed by Dr. PRP Kits.

Some researchers have suggested using Leukocyte-poor PRP for Osteoarthritis but there isn’t enough evidence to support the notion that having less leukocytes enhances OA treatment results. In fact, there are some RCTs like this that used leucocyte-poor PRP that have failed to produce significant results while leukocyte-rich PRP had a beneficial effect as evidenced by this study.

Bone regeneration

Bone regeneration is a little-known field of medicine where Platelet-Rich Plasma has been quietly performing well. In a 2014 study, researchers concluded that there is little doubt that PRP can be beneficial for bone regeneration. But the mechanism through which PRP was able to achieve this is still largely unknown. Recently, researchers in Japan has discovered that a combination of Bone Marrow Stem Cells and PRP appeared to enhance bone formation in mice. Another RCT by Iranian researchers suggested using PRP along with autologous bone graft for long bone non-union fractures.

Platelet-Rich Plasma has also been compared with bone marrow aspirate (BMAC) concentrate by Japanese researchers and they found that PRP has almost the same capability for bone regeneration as BMAC. This is significant considering the simplicity of PRP extraction vs BMAC extraction.

Orthopedic-Surgeons-Guide-Platelet-Rich-Plasma-Injections

There is another meta-analysis by Korean researchers that looked at the effect of Platelet-Rich Plasma on Sinus Bone Graft. Again, the study concluded by saying PRP is beneficial.

Muscle, ligament and tendon regeneration

Historically, tendons are known to respond well to Platelet-Rich Plasma. And this review of current literature confirms the fact. This review also concluded that Leukocyte-Rich PRP (the normal PRP) was more ideal for intratendinous injections.

Platelet-Rich Plasma also has a long history with tennis elbow and Rotator cuff injuries. Researchers in China looked at 8 randomized controlled trials (RCTs) that involved 511 patients with tennis elbow and came to the conclusion that PRP is a more ideal treatment than steroids.

But PRP’s relationship with Rotator cuff injuries suffered a setback last year when a Chinese review concluded that PRP is not beneficial. Prior to that, AAOS had reported that it might be beneficial.

Spine regeneration

Intervertebral disc degeneration is one of the leading causes of lower back pain and is usually the one of the most expensive conditions to be treated – mainly due to the complexity of the condition. In one case we know, a patient with degenerative disc condition in both his lumbar and cervical spine – he had both a degenerative bulging disc at L4 and a sacroiliac joint dysfunction – was still pain-free 2 years after his doctor administered 2 PRP injections. But for this post, let’s put anecdotes aside and look at latest studies like this by Chinese researchers which seems to support the notion that PRP is indeed beneficial for retarding intervertebral disc degeneration.

Another study by researchers in New York also found that PRP is beneficial in the treatment of degenerative intervertebral discs.

Over 100 active clinical trials on Platelet-Rich Plasma

What we’ve presented here is only a fraction of the literature available. As you can see, this is an interesting time of development for Platelet-Rich Plasma. It continues to be of great interest to medical researchers and the patient population. Though the scientific community is torn apart by the lack of standardization and “hard evidence” for PRP treatments, patients are showing huge interest in it even though they have to pay out-of-pocket for these injections. And the reason why patients are voting with their wallets for this treatment is because 1) it’s simple and highly practical and 2) lot of anecdotal evidence. The research community is trying hard to catch up to these patients’ belief – there are currently over 100 active clinical trials on Platelet-Rich Plasma – and we believe it’s only a matter of time before they succeed in their quest. The lack of funding is only major hurdle the research community has to overcome before they uncover the full therapeutic effects of Platelet-Rich Plasma. And we’re excited and so should you because it’s great news for your patients.

Orthopedic-Surgeons-Guide-Platelet-Rich-Plasma-Injections

But for now, there’s plenty of evidence to suggest that Platelet-Rich Plasma treatments can be a standard regimen for treatment of musculoskeletal disorders. In the coming years, you will see more standardization in PRP preparation, concentration, pre-activation, injection volume, injection frequency and post-injection protocols.

The Cost Effectiveness of Platelet-Rich Plasma

One other thing to keep in mind, when weighing on the pros and cons of offering Platelet-Rich Plasma to your patients is the cost-effectiveness. Yes, you may not want to waste your patient’s money. But Platelet-Rich Plasma is something that has enormous upside with a relatively low downside. This is especially true when compared to surgical intervention. Average cost of the highly invasive arthroscopic debridement, for example, is $5000. But the same results may be obtained by 3 shots of PRP that costs $1000. The amount of improvement reported by patients undergoing both is similar – about 50%. That’s $20 for every percentage point improvement vs $100 for every percentage improvement in the case of arthroscopy. Even if the patients have to pay out-of-pocket for PRP injections, that’s not a good reason why they should not try Platelet-Rich Plasma.

Check out our Platelet-Rich Plasma kits here.

Orthopedic-Surgeons-Guide-Platelet-Rich-Plasma-Injections

Dermatologists Guide To Platelet-Rich Plasma PRP Hair Regeneration Hairloss Treatment
The Dermatologist’s Guide To PRP Hair Regeneration

As a powerful medium of regeneration, Platelet-Rich Plasma has seen the most aggressive growth in demand among patients suffering from Alopecia. This is despite the relative lack of evidence surrounding the treatment. All because the results of PRP Hair Regeneration just can’t be ignored.

Dermatologists Guide To Platelet-Rich Plasma PRP Hair Regeneration Hairloss Treatment

And researchers are starting to take it more seriously now.

New studies are emerging that prove the results are more than just opinions of dermatologists. The most recent one is a study published by Egyptian researchers, where they analyzed the results of 90 patients for a period of 3 months using digital camera photography and dermoscopic scans, and concluded that Platelet-Rich Plasma is more effective in the treatment of Alopecia than widely accepted topical minoxidil 5% solution.

Dermatologists Guide To Platelet-Rich Plasma PRP Hair Regeneration Hairloss Treatment

Prior to that, in a literature review by University of Miami and Brown University researchers, they found that, among the 12 studies they looked at, 10 of them had positive results showing Platelet-Rich Plasma was beneficial in treating Alopecia.

The Holy Grail Of Hair Science?

One of the most interesting studies is a study conducted by researchers in Southern Medical University, China. Although the study was conducted on lab mice, it presented very conclusive evidence for Platelet-Rich Plasma as a powerful biologic substance that both shortened the time of hair formation and increased the number of newly formed follicles. The possibility that Platelet-Rich Plasma can promote both of these functions at the same time makes it the holy grail of hair science.

There’s also this other study By Italian researchers suggest that the optimal concentration of Platelet-Rich Plasma for PRP Hair Regeneration is 1.5 million platelets per microliter and that higher concentrations doesn’t seem to improve results (or may at times minimize the results). Although the study size is small (20 patients), it reported significant positive results after administering three PRP injections for each patient at 30-day intervals.

Little wonder that during the AAD 2017 Summer Meeting, it was one of the hottest topics discussed.

American Academy of Dermatology 2017 Summer Meeting

At the American Academy of Dermatology 2017 Summer Meeting, which took place a few days ago, Dr. Neil Sadick, MD, from Weill Cornell Medical College, was quoted as saying  that Platelet-Rich Plasma is the hottest therapeutic tool dermatologists nationwide are talking about. Dr. Sadick also acknowledged the lack of a standardized treatment protocol that is holding back the procedure from going mainstream. But all of this is about to change as he mentioned that there are three MAJOR ongoing studies on the topic of PRP Hair Regeneration currently, whose outcome may shift they way this treatment is perceived right now.

Dr. Sadick’s co-presenter, Dr. Maria Hordinsky, MD, said that there’s no question that the demand is growing. And advocated dermatologists to start accepting the reality that if they don’t believe in it now, their customers might go somewhere else to get it.

She concludes by saying, “You have to get on the bandwagon of PRP if you work with patients with hair loss. There is no choice. It is very popular.”

Lack Of Evidence Or Lack Of Funding?

The lack of clinical studies may allude to the fact that funding for this kind of research is next to impossible to obtain. The Brown University and University of Miami researchers who conducted the literature review we cited earlier did not receive any funding for their work.

And so are almost all other literature on PRP Hair Regeneration. It explains the relative lack of robust evidence. But the dermatologists on the field are amazed by growth in demand they’re seeing. PRP looks like a disruptor in the long-stagnant Hair Regeneration industry. What they thought was a passing fad is now turning out to be a powerful force.

Isn’t time that every dermatologist in the country embrace Platelet-Rich Plasma as a standard treatment? Read this article to learn about other reason why you should consider offering the Platelet-Rich Plasma suite of treatments.

Dermatologists Guide To Platelet-Rich Plasma PRP Hair Regeneration Hairloss Treatment

82% “Worth It” Rating In Real Self

Perhaps the best indicator of the effectiveness of a treatment is the customer feedback. The website Real Self is a portal that lists different cosmetic treatments and asks its user to share their experiences. PRP Hair Regeneration is among the most popular treatments discussed in that portal. And on this portal, PRP Hair Regeneration has a whopping 82% “WORTH IT” rating as rated by real customers who’ve had the treatment. It is also the cheapest treatment listed on the site with an average cost of just $1675.

One user in Real Self, who posted a before-after picture that was taken after only ONE PRP treatment, says he was impressed by how much Platelet-Rich Plasma had thickened his receding hairline. Comments like this are not uncommon on the Real Self portal.

More and more patients are seeking out PRP Hair Regeneration instead of the oral drugs and topical medicines because of its holistic, regenerative aspect. This is a “true solution” for hair loss with NO MAJOR SIDE EFFECTS.

Dr. Amiya Prasad, MD, a cosmetic surgeon and fellowship-trained Oculofacial plastic and reconstructive surgeon who’s been in practice for over 20 years, says, he has no doubt about the efficacy of PRP Hair Regeneration. In fact, he even says that he’s never seen any reversal of results in his patients.

Dermatologists Guide To Platelet-Rich Plasma PRP Hair Regeneration Hairloss Treatment

6 Lessons From More Than 1,000 PRP Hair Regeneration Treatments

Here are the tips shared by top dermatologists who’ve each performed more than 1,000 PRP Hair Regeneration treatments for their clients.

  • 1. There is no substitute for precise intra-dermal injection of Platelet-Rich Plasma at the level of the follicles.
  • 2. It may be helpful to be supported by micro-needling and topical Platelet-Rich Plasma in some cases.
  • 3. The concentration of platelets must be at least 5x the baseline or 1.5 million platelets per microliter (μL).
  • 4. Combining Platelet-Rich Plasma with non-surgical medication and laser light therapy may be beneficial.
  • 5. PRP Hair Regeneration is usually done 3 sessions about 1 month apart, followed by one more session about 12-18 months later depending on the results.
  • 6. Addition of an allograft matrix product to Platelet-Rich Plasma can greatly enhance the results of regeneration.
How to Prepare Platelet-Rich Plasma

Based on the input from dermatologists and Platelet-Rich Plasma experts, here’s how you can prepare the Platelet-Rich Plasma for hair regeneration.

There are three types of Platelet-Rich Plasma Kits. The ones that uses separator gels, ones that uses buffy coat with a single spin on the centrifuge and the ones that uses buffy coat with double spins on a centrifuge. Almost all physicians agree that the last option – using a buffy coat based Platelet-Rich Plasma kit that can be double spun produces the best concentration of 5X-7X above baseline, i.e., more than 1.5 million platelets per micro liter.

Dermatologists Guide To Platelet-Rich Plasma PRP Hair Regeneration Hairloss Treatment

This concentration packs the most nutrients for the regeneration of blood vessels and recruitment of new stem cells that are required for hair regeneration.

The way to achieve this concentration using the DrPRP Kit is simple.

  • 1. Draw 17cc of blood into a DrPRP tube pre-filled with 3cc Anti-coagulant ACD-A.
  • 2. Centrifuge it for 3400 rpm for 4 minutes.
  • 3. You’ll see perfect PRP separation (else you can centrifuge it for another 1 minute.)
  • 4. Sequester the platelet serum from the RBC by adjusting the knob at the bottom of the DrPRP tube.
  • 5. Centrifuge it for another 6 minutes at 3,200 rpm.
  • 6. You’ll get about 10cc of Platelet serum with Platelets lying at the bottom of the chamber. Draw out the top 6cc of the serum, which is the Platelet-Poor PRP.
  • 7. The remaining 4cc is your Platelet-Rich Plasma that has more than 1.5 million platelets per micro liter. Shake it well, draw it out in a syringe and administer it.
With Micro-needling Or Without?

Some dermatologists’ recommended PRP Hair Regeneration protocol includes Micro-needling with topical application of Platelet-Rich Plasma. In some cases of hair loss, this can have a beneficial effect.

Dermatologists Guide To Platelet-Rich Plasma PRP Hair Regeneration Hairloss Treatment

Micro-needling, using a device like Bella, creates a series of micro-trauma that warrants a healing response in a manner that covers the entire area of the scalp. This together with the applied Platelet-Rich Plasma will stimulate growth activities in the cells.

Most dermatologists who do micro-needling sandwich it between PRP injections. Say they’re giving a 3-session treatment at a 30-day interval, they’ll inject Platelet-Rich Plasma deep into the derma for the first and the last treatments while the second treatment will be just the Micro-needling with topical application of Platelet-Rich Plasma.

So yes, it is purely optional. With or without this, there is no avoidance of intra-dermal application of Platelet-Rich Plasma for PRP Hair Regeneration. Micro-needling with PRP is most effective for skin rejuvenation of wrinkles and sun damage.

If you’d need a micro-needling system, check out our Bella Micro-needling device. It’s been used by some of the top skincare centers we know.

Dermatologists Guide To Platelet-Rich Plasma PRP Hair Regeneration Hairloss Treatment

PRP with Allograft Matrix

One of the hidden gems we uncovered when looking at Hair Regeneration experts is that they often combine Platelet-Rich Plasma with some kind of allograft matrix. Allograft matrices are widely used in chronic wound healing – it actively changes inactive adult stem cells back into progenitor cells (its active form) and facilitates faster healing and regrowth.

When a high concentration of Platelet-Rich Plasma is combined with Allograft matrix, the matrix acts as scaffold for growth-factor induced cellular proliferation. There are many respected hair restoration experts in the field offering this combination with a very high degree of success. One prominent NY-based hair restoration expert says this combination has never failed to work in his practice with hundreds of clients.

The most commonly used Allograft matrix is derived from porcine urinary bladder tissue. But we recommend a more superior allograft matrix that is derived from amniotic fluid and tissues. This type of Allograft matrix is “immune privileged” meaning that it can be introduced into the body with virtually no chance of a harmful immune response as compared to allografts obtained from porcine bladders.

If you want to choose an allograft product, take a look at our post on the topic.

DrPRP USA Amnion Allograft Matrix For PRP Hair Regeneration

Standard drugs vs PRP Hair Regeneration

So far the widest prescribed drugs for male pattern hair loss are Minoxidil and Finasteride. These drugs are designed to prevent progression of hair loss. Minoxidil works by opening up the cell channels allowing more oxygen, blood, and nutrients to reach the follicles. Finasteride prevents the conversion of testosterone to dihydrotestosterone (DHT) which translates to less androgen activity in the scalp. In other words, these are temporary solutions. If these drugs are discontinued, any therapeutic benefits will reverse within about 6 months. I think almost every physician knows that. And the people who take these drugs will still lose hair as it’s not 100% effective in its function of stopping hair loss. Plus as I said, there’s no stimulatory effect on hairs.

You may know where I’m going with this. Platelet-Rich Plasma is a whole another story. It’s perhaps the only treatment out there that has clinically proven to regenerate hair follicles. Meaning it not only slows down hair loss, it actually helps promote new hair growth. The question is how long can the effects last. Some patients report that a single injection treatment with a combination of PRP and Allograft injection has produced for them hair regeneration results for FIVE YEARS AND RUNNING. Of course, different patients have varying outcomes.

The point is… until recently we only had two serious options for hair loss recovery. We had drugs that produced temporary effects, and we had surgery that transplanted hairs. And nothing in between. That’s why PRP Regeneration has gained a lot of traction recently.

This doesn’t mean all other treatments are obsolete. Some patients prefer a comprehensive approach to battling hair loss and they’ll want to fire-on-all-cylinders right from the start. Fortunately, Platelet-Rich Plasma treatments have little side effects or contra-indications and can be safely combined with other treatments.

Combining PRP with other treatments for maximum results

We haven’t found any adverse effects in using Platelet-Rich Plasma with either the Minoxidil foams or the Finasteride drugs, nor with other Laser light scalp stimulation therapies. So potentially you could do it all together. It’s entirely up to your patients – whether they want to focus on PRP Hair Regeneration alone or also pursue temporary solutions like drugs, foams and light therapy.

Another potential treatment that can be combined with Platelet-Rich Plasma and Allograft injections is Vitamin D. Vitamin D is proven to increase transformation of hair follicles.

Get On The Bandwagon Of Platelet-Rich Plasma

The trend for PRP Hair Regeneration, PRP Skin Rejuvenation, PRP Sexual Revival And PRP Facelift Procedures are on the rise. And it’s not showing signs of any slow down.

As many of the dermatologists already believe, you have to get on the bandwagon – there’s no choice. The demand for this treatment is only growing. And by refusing to believe in it, you’re potentially denying your customers their right to use regenerative medicine.

Dermatologists Guide To Platelet-Rich Plasma PRP Hair Regeneration Hairloss Treatment

If you’d like to talk to us about the specifics of various protocols, give us a ring at (844) 377-7787. Or head on to our shop to order a trial pack. We’ll be happy to assist you in making a decision about Platelet-Rich Plasma. And don’t worry, we’re not sales professionals. We’re medical professionals just like you. : )

drprp Platelet-Rich Plasma prp kit samples

Dr. PRP Kit Samples — Order Yours Now

Once you enter your email and confirm you'll receive the link to order your samples. Plus, you'll also be subscribed for updates and news from the Dr. PRP USA team. 

You have Successfully Subscribed!