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Top Six Reasons Why Platelet-Rich Plasma Injections Fail

The other day we received an email from a person who had Platelet-Rich Plasma (PRP) Injection that failed to produce any results. “Not impressed, did not work for me. Had it done for my back,” she said. Comments like these are charged with emotions as almost all of these patients have paid for PRP injections out of their own pockets. That’s why the same patient also added later “…but did empty my wallet.” For us, her comment was one of the kinder ones. Others, who were really mad at seeing their money wasted, called it a sham, quackery, and “ways for doctors to make money.” We understand this sentiment. And we can’t argue with the fact that these treatments may have been failures.

But the thing is very few people, including some expert physicians understand why these PRP injections fail.

What The Tremendous Popularity Of PRP Means

In the 1990s, there were about 150 new research articles on Platelet-Rich Plasma every year. At least in the Pubmed database. Back then, only a select group of physicians who really understood the treatment actually offered it to their patients. Now, just this year alone, there were more than 600 new articles. The trend line has gone from a gradual climb to a “U curve” or exploding popularity.

Platelet-Rich Plasma PRP Injections Search Results Pubmed Database

And so did the number of physicians offering this treatment.

Certainly, money wasn’t the objective for those physicians – for if it were, the best ways to do it would’ve been to prescribe a battery of tests, drugs and surgeries approved by insurance companies. Instead, the physicians started offering it once they knew well the inherent benefits of an interventional autologous medicine like Platelet-Rich Plasma.

The problem is, not all physicians were that passionate about it.

Some did it because patients asked for it. Some did it because everyone else was doing it. Still others just wanted to experiment with it casually.

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And so not all Platelet-Rich Plasma injections worked. That’s why, as the treatment exploded in popularity, we saw a small portion of those treatments end up being a waste of the patient’s money – and that gets talked about a lot because, as I mentioned above, the patient usually has huge emotional response to the outcome.

But on the other hand, majority of the patients are happy about their results.

“I had it done on my injury and MAN, IT REALLY WORKS!!!”

That’s another response we got on the SAME DAY that this women told us it didn’t work for her. Another physician also told us the very same day, “PRP works great. We have had fantastic results on patients in the office.”

So what’s making the difference?

Why do some PRP treatments work spectacularly while some others turn out to be a dud?

That’s what we’ll explain in the rest of this post here. There are six main reasons why it can fail. Plus a seventh no-so-common reason. Let’s look at them one by one.

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1. Improper Selection of Patients

As much as the Platelet-Rich Plasma injection enthusiasts would like beat the drum of its universality of application, there are certain instances where a PRP injection may be unnecessary. The classic case is demonstrated in the 2015 Double-Blind Randomized, Placebo-controlled Study that showed that PRP injections are NOT beneficial at all.

According to expert researchers we subscribe to, it is clear that this study had selected the WRONG PATIENTS!!!

Here’s what that means. This study, conducted by researchers at Cooper Medical School of Rowan University, New Jersey, was done in the emergency care department where patients who’d just had a ankle sprain were given a Platelet-Rich Plasma Injection.

First of all, ankle sprains are relatively acute medical condition, commonly occurring due to over-stretching and tearing of the muscle or tendon. And they’re usually healed on their own. The thing that emergency care physicians usually do for this condition is to put ice packs or local anesthetic to numb the pain so the patient can rest. For patients who’re very active, their body is able to heal itself from most of these types of ankle sprains very rapidly. For them, a PRP injection might not accelerate healing. On the other hand, because injections break up the tissue and poke holes, it can actually cause unnecessary complications.

That’s why successful studies on Platelet-Rich Plasma Injections are almost always done on chronic wounds and injuries that wouldn’t heal on its own. If you’re out to test PRP’s efficacy, the untreated-by-PRP “control group” should be non-healable so we can determine clearly the effects of PRP.

So definitely, Platelet-Rich Plasma injections are not ideal for emergency care.

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The same is true for patients on the other end of the spectrum. That is the category of patients who’d been on steroids and drugs for a long time and are in the very advanced stages of the disease. Although there might be hope, Platelet-Rich Plasma might not be enough to reverse course here.

The ideal candidate for Platelet-Rich Plasma injection is a patient who has a relatively new, chronic musculoskeletal condition and whose only other option is surgery or heavy steroid/drug use.

2. Use of certain drugs

One of the other reasons why Platelet-Rich Plasma may not be ideal for emergency care patients is that when patients come in with intense pain, it’s a common practice for the ER physician to administer powerful local anesthetics and/or steroids in high dose. The problem with both of them is that they are are known to be toxic to stem cells and growth factors as shown here here, here and here. So if you’re using these steroids, anesthetics or drugs, it is recommended to wait till the patient can get off of them before applying Platelet-Rich Plasma. Otherwise, the toxicity of the chemicals may limit Platelet-Rich Plasma’s ability to recruit stem cells to the area.

For example, the local anesthetic Marcaine is found to be extremely harmful to stem cells even in small quantities. So as a general practice, the patient has to avoid harmful steroids, anesthetics and drugs at the time or up to 48 hours prior to PRP injections.

3. Lack of Rehab

It’s been reported that PRP injection works well when combined with the physical therapy for sports injuries. However, some physicians mistakenly see PRP injections as an alternative to physical therapy. Hence the comparisons like these where PRP is pitted as a rival to physical therapy. The fact is Platelet-Rich Plasma can only supplement the effects of a proper rehabilitation program as illustrated in this study which demonstrated that PRP + physiotherapy is more effective than Dry Needling + Physiotherapy for patellar tendonisis.

There is one thing we need to add to that though. Most PRP injections are done in a way that breaks up scar tissue and triggers new healing response to which the platelets can respond. So the best post-Platelet-Rich Plasma treatment rehab program is one which treats the patients as if they just had an acute injury. Meaning, the physiotherapy regimen following a PRP injection has to aim at square one – stimulation of blood flow to the injured area to provoke the inflammatory response. This is a different approach than the usual where the PT tries to attenuate the inflammatory response.

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4. Under dosing

Under-dosing is a serious problem in this field. If you’re using PRP with below 3X platelet concentration, you’re under-dosing your patients. An example is the PT vs PRP study we highlighted earlier. Not only did they mistakenly conclude that Platelet-Rich Plasma could be an alternative to Physiotherapy, they were severely under dosing the patients by using PRP with 2.1-2.5X concentration of platelets.

Studies have shown that a concentration of at least 1,000,000 platelets/µl is needed for optimal therapeutic benefits. That is 5X the concentration of platelets in normal whole blood. Here is one such study.

That is the very reason why we advocate not using Gel-based PRP Kit for PRP separation. The problem with gel-based kit is that most of the platelets will get trapped in the gel. Instead a kit like DrPRP kit gives you 5X-9X platelets because it uses a mechanical separation process while giving the same 1-step convenience of gel separators.

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5. Using PRP as just another injectate

There is a fundamental difference between Platelet-Rich Plasma based orthopedic intervention and typical modern surgical and drug-based treatment. And that is surgery and the drugs are designed to eliminate symptoms of diseases. For example, pain is one of many symptoms that occur when a certain part of the body is out of balance. By taking a drug, steroid, NSAID or even undergoing surgical correction, the physician hopes that the pain goes away. This approach has led to all the problems that we face in modern orthopedic medicine. Because when we treat symptoms, the underlying problems usually don’t go away.

But scores of physicians look at Platelet-Rich Plasma with that same attitude. They inject Platelet-Rich Plasma expecting the symptoms to go away.

That’s NOT what Platelet-Rich Plasma is for.

Platelet-Rich Plasma is a HEALING AGENT. It’s different. It’s not designed to eliminate symptoms like a drug. The only thing that PRP can do is use the body to heal itself.

So the first task, if you’re an orthopedic surgeon or someone treating a musculoskeletal issue, is to IDENTIFY precisely what’s producing the symptoms. This means looking at the connection between various muscles, tendons and ligaments. Understanding how they work in unison and finding out what’s causing stress in the system. All the muscles and ligaments and tendons are like different pieces of the puzzle – pulling weights in sync with their functions. So if there’s a anomaly in the whole picture, chances are one of the pieces of the puzzle is not able to carry out its job.

For an easy example, a tightness in the hamstring might be a result of a twisted ligament or bone in the back caused by a bad sitting posture. So in addition to injecting PRP to the hamstring, you might also need to inject to the ligament or bone on the back. And advise the patient to change posture.

This is the definition of Interventional Orthopedics.

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And it requires extensive experience on the anatomy – AND delivering precise injections into the weaker links in the musculoskeletal system to improve overall function of the body. This means using image guidance technologies like fluoroscopy (Ultrasound guidance isn’t enough) to accurately place Platelet-Rich Plasma on areas which require healing. These type of injections enable efficient tissue regeneration and healing, and is usually not taught in medical school, residency, or fellowship.

That’s why we encourage physicians who’re offering PRP injections to get certified by taking one of the courses at the non-profit Interventional Orthopedics foundation.

Getting certified in Advanced Injection practices will make your Platelet-Rich Plasma results more consistent. There is a must-have for all physicians offering PRP Injections. It will also educate you on all the different ways regenerative medicine is being used right now.

6. Thinking only about relieving pain

We touched on it a little on the section above, but this is a broad topic that deserves an explanation on its own. Platelet-Rich Plasma as a healing tool is not something that you should make use of when your patients are in pain. Instead, PRP is used for a wide variety of issues that doesn’t involve pain including wound healing, skin aging reversal, wrinkle correction, dry eye syndrome, nerve regeneration, bone union, hair regeneration and even women’s fertility restoration and strengthening the uterus.

The bottom line is… Platelet-Rich Plasma isn’t just a tool for containing pain due to sports injuries. That days are far behind us now. Today, every physician, from the family physicians to neurologists and cardiologists, to fertility specialists and optometrists, to dermatologists and hair restoration experts… everyone uses Platelet-Rich Plasma.

Plus, more and more applications are discovered every day.

Platelet-Rich Plasma, on its own without funding by Big Pharma or the government, has become an integral part of modern medicine.

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BONUS: The 7th Reason Why PRP Injections Fail

7. Super-concentration of Platelets

We know all analogies are imperfect but we like to use the expresso shot analogy when it comes to platelets. Platelets are like expresso shots for healing. But like expresso shots, your body can’t function using expresso shots alone. It needs food. That’s why studies like this one by Giusti has shown that super concentrating the Platelets may not only be useless, it can actually be harmful. What they did was completely isolate Platelets and platelets alone – and applied it in different concentrations on tendon cells to see if higher concentrations hurt or helped. That’s not Platelet-Rich Plasma. That’s just platelets.

And Platelets alone can’t do the job. In fact, it has nothing to support the survival of cells.

Instead, Platelet-Rich Plasma, is rich in Platelets while also including a small portion of RBC, WBC and the plasma serum which contains the nutrients the cells needed to survive.

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That’s why research shows that taking the concentration above 1,000,000 platelets/µl doesn’t necessarily increase therapeutic benefits and as the Giusti study pointed out, it can actually have a detrimental effect.

This may not be an issue for the average physician, but it is possible to make this mistake thinking that higher concentration is better. That’s why we believe choosing the right Platelet-Rich Plasma kit plays an important role.

Because the kit has to produce Platelet-Rich Plasma in the ideal concentration – not just Platelets – so it can work every single time you administer it on patients.

Patent Application By Allan K Mishra

Speaking of the composition of Platelet-Rich Plasma, the famed Stanford researcher and Platelet-Rich Plasma pioneer Allan K. Mishra has recently filed a patent application titled “PLATELET RICH PLASMA FORMULATIONS” which can be found here. In it, Mishra claims he’s identified specific concentration of platelets, red blood cells, and white blood cells for treating treating connective tissue and/or cardiac tissue damage. It’s worth a look if you’re curious.

Add Regenerative Medicine to Your Practice

If you need help in getting started with Platelet-Rich Plasma, don’t hesitate to give us a call at (844) 377-7787 for a quick consultation. We can support you not only in supplying all the necessary equipment, but also provide you with the information you need to be a confident pioneer in this field. We’re looking forward to having you as part of our family.

You can also email us via hello@drprpusa.com or visit our shop to order directly.

Thank you for reading our blog. We love you.:)

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Why Doctors Are Now Ditching Steroid Injections For PRP

The use of immunosuppressive biologics, non-steroidal drugs (NSAIDs) and corticosteroids, collectively known as Anti-Inflammatory Therapeutics (AIT), has been rebuked by many, including well-known MDs. But there are, still, a good majority of family doctors, pain-management specialists, and orthopedic surgeons who routinely prescribe them for arthritis, tendonitis, and bursitis because apparently, there’s no other better alternative. This is evident in the ballooning anti-inflammatory therapeutics market which is projected to reach a valuation of $100 Billion by 2020. But according to researchers, there already exists a better alternative and that is Platelet-Rich Plasma and scores of physicians are now prescribing it as a first line treatment instead of AITs.

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Why Anti-Inflammatory Therapeutics?

One of the reasons why AITs are popular is the belief that most musculoskeletal diseases are due to inflammation. It is believed that inflammation is the cause of injuries and pain. But over the years, numerous studies have shown, rather persuasively, that inflammation is a signaling process used by the body to recruit growth factors and cytokines to the tissue microenvironment. While suppressing the inflammation with drugs interrupts this natural process and provides short term relief to the symptoms, in the long run, it prevents structural healing.

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But the argument among pro-AIT physicians is that they provide the best short term relief. They claim that a short or two of AITs keeps the situation under control and is not a big deal in the larger scheme of things.

Not true. They have pain-relieving properties but not as dramatic as we may think.

First, corticosteroids are not as the ultimate pain-killers and there are other methods far superior.

Second, neither can NSAIDs be considered the most effective pain-killers and that’s a fact.

Third, the immunosuppressive biologics like DMARDS, cytokine-blockers and TNF-blockers are not effective pain-killers anyway.

But they all have one thing in common. And that is, a long-list of side effects.

The Debilitating Effects of AITs

It would have been acceptable if we could just temporarily harness the whatever little pain-relief that AITs offered while we’re looking for a favorable course of action. But that isn’t the case. Studies show that even a single dose of these AITs can lead to unwanted complications. Let’s take a deeper look.

1. Steroids
Steroids are evidently the most destructive ones. Physicians know that they must prescribe steroids very cautiously. But the problem is once they work, patients may prefer them again and again. Especially athletes who just want to get back in the arena for that final game. After all, who wants to sit on the sidelines when life passes by? Just one more time, they’ll say.

But the long term effects are disastrous. Not only are they hard to get off of, the steroids have the ability to kill mesenchymal stem cells, lead to cartilage loss, and are one of the most common causes of secondary osteoporosis. Scores of athletes and weekend warriors have used steroids to temporarily push away pain only to end up in the surgery table a few years later.

2. NSAIDS

NSAIDs are a totally different beast. Medscape reports that more than 70 million of them are prescribed to patients each year in the United States alone. This is in spite of the warning issued by the Arthritis, Rheumatism, and Aging Medical Information System (ARAMIS) against NSAID use.

To the patient, it sounds like a decent proposal – use non-steroidal drug to temporarily alleviate pain. However, the consequences are enormous. In this comprehensively researched article on the Journal of Prolotherapy, the writer calls for a total ban on the use of NSAIDs for joints owing to its potential for degenerating cartilage. This is alarming considering that majority of the NSAIDs are prescribed for joint conditions like arthritis. In another study, use of NSAIDs was shown to have tripled the progression of Knee Osteoarthritis.

Furthermore, even in the 1980s researchers have found that NSAIDs can disrupt intestinal integrity.

3. Biologics

Anti-inflammatory biologics include drugs that block pro-inflammatory cytokines like tumor necrosis factor alpha (TNF) and interlukin-6 (IL-6) as well as conventional disease-modifying antirheumatic drugs (DMARDs). The problem with these drugs is that they suppress the biologic entities responsible for the natural immunity of the body. Applying them to a joint for example, doesn’t limit its effect to that area. Instead, it suppresses these biologic entities THROUGHOUT the body including liver, colon, small intestine, bones, skin and even neurons.

That’s why they have been linked to neurological diseases, and other diseases.

Blocking pro-inflammatory cytokines are definitely a bad idea. For example, the cytokine IL-6, one of the main cytokines targeted by the new generation of Arthritis drugs is a major component of the central nervous system. So is anti-TNF drugs. Blocking these can only lead to adverse events in the long term elsewhere in the body.

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Can PRP Disrupt The Anti-Inflammatory Therapeutics Market?

Although not immediately evident, the trend for these Anti-inflammatory Therapeutics are actually going down. As researchers discover more serious side effects, the market will start shifting to more natural solutions like Platelet-Rich Plasma. In fact, it’s already happening as we speak. Even without the support of insurance companies, more and more people are opting for PRP instead of AITs. That means people are willing to pay out-of-pocket for PRP instead of accepting free drugs. In other words, the downward trend for AITs has begun.

Patients and physicians are learning the hard way that SUPPRESSION OF INFLAMMATION DOES NOT EQUAL TO HEALING.

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On the other hand, the trend for Platelet-Rich Plasma is climbing organically.

Here’s Allen Mishra’s tweet about PRP’s Google trends. Alan is the founder of the Biologic Orthopedic Society that has over 6,500 members in Linkedin.

Independent research is also catching up with Platelet-Rich Plasma. It has proved so far that PRP is far superior for:

1. Chronic low back pain

The study shows that sacroiliac joint (SIJ) injection of Platelet-Rich Plasma has a longer-lasting effect on pain than steroids. And the difference is HUGE. While efficacy of steroids was only 25% at 3 months, it was 90% for PRP.

2. Tennis Elbow

In this study, the steroids were only able to suppress symptoms for recalcitrant lateral epicondylitis, while PRP was able to biologically heal the lesion. Furthermore, the steroids caused further tendon degeneration. Another study proved that patients who had PRP shows better pain and functional improvements than patients who had corticosteroid injection.

3. Plantar fasciitis

This randomized, blinded study concluded that PRP delivered at least the same pain-relief results as steroids. Other researchers have concluded that PRP is actually more effective than steroid injection in terms of pain and functional results. Another study also proved that PRP was more effective and durable than cortisone for plantar fasciitis. Yet another British study also pointed out that PRP injections are superior to corticosteroid injections.

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4. Knee Osteoarthritis

The study above showed that intra-articular PRP injections are better than HA, ozone, and corticosteroids. Another study recently proved that PRP injections are better than Hyaluronic Acid for knee osteoarthritis.

5. Rotator Cuff Tears

This study proved that Platelet-Rich Plasma injections show benefit earlier than cortisone injections for rotator cuff tears. Another similar study also found that a single dose of PRP is better than steroid for Shoulder impingement syndrome.

Why PRP Is Actually Good For Both Patient And Physician

As you can see, the reason why more and more physicians and patients favor Platelet-Rich Plasma over Anti-inflammatory Therapeutics is that PRP not only eliminates the symptoms (pain and function) but it actually heals biologically. Yes, of course, the manufacturers of the conventional drugs would love you to believe that their billion-dollar-research-backed miracle drug is VASTLY superior to the autologous Platelet-Rich Plasma that can be produced within 10-20 minutes in a small clinic. But what we’ve seen is quite the opposite.

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One of the early pioneers of Platelet-Rich Plasma, an orthopedic surgeon Dr. Allan Mishra, M.D., says, that soon this biologic tool would be “safe, simple to use, inexpensive, and available immediately at the point of care.”

And that requires a tipping point in its adoption by physicians. It’s already accelerating at a good pace.

Dr. Mishra goes on to say that, “chronic tendinopathy is the most common indication for applying PRP in my practice. I have used the treatment for tennis elbow, patellar tendinosis, partial Achilles tendon tears and occasionally partial rotator cuff tears as a stand-alone treatment. I also now routinely augment all of my Achilles and patellar tendon repairs with PRP. And I am considering augmenting my arthroscopic rotator cuff repairs as well with PRP. For nonunions or difficult fractures, I combine PRP with bone grafting.”

For the patients, Platelet-Rich Plasma has been helping them avoid surgery for years now. See the videos below for actual testimonials from real patients.

Here’s another patient’s story of how PRP helped avoid surgery.

“When I tore my rotator cuff in 2008, I had conventional laparoscopic surgery to repair it. The outcome was excellent, but the recovery was long and horrible. The orthopedist wouldn’t let me drive for six weeks, or run, swim or lift weights for three months. I suffered through weeks of torturous physical therapy. It was nearly six months before I felt normal again.”

And the patient vowed to never go through that ever again.

Unfortunately, the patient suffered another injury in 2014.

But this time decided to try Platelet-Rich Plasma instead.

The patient said, “I had the first PRP injection on Oct. 23. It was painful, and the aching persisted for about 36 hours. I had one bad night, followed by an uncomfortable day. After that, the pain stopped. Still, my doctor advised me to baby the shoulder — to use my other arm when holding a dog leash and to skip swimming and weights for two weeks. Running was fine. He also recommended physical therapy after two weeks.”

The patient reported that by February 2015, the shoulder was 80% healed. The doctor advised the patient to have a second PRP injection to heal the remaining 20%.

Here’s what the patient said:

“I had [the second injection] on March 4. When I returned to see [the doctor] on April 12, I was feeling pretty good. No pain, no problems. He rolled in the ultrasound machine, and I was not surprised by the results.”

Watch this second video for another excellent patient story.

Get Started On Platelet-Rich Plasma Now

The best way to start making a big difference in your patients, especially if you’re an orthopedic surgeon, rheumatologist or any kind of pain management specialist, is to get going with Platelet-Rich Plasma. Don’t just have it as a back up treatment that you can try when things don’t go well. Instead, it can be used as a standard first-line treatment for musculoskeletal issues.

Give it a serious consideration.

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We can guarantee that once you start offering Platelet-Rich Plasma, you’ll end up prescribing less and less Anti-Inflammatory Therapeutics and more and more Platelet-Rich Plasma. And it will have a tremendous impact on the lives of your patients. We want to see a world where the “replacement surgeries” are a thing of the past.

And Platelet-Rich Plasma can make it happen.

Give us a call if you need more information. We can be reached at (844) 377-7787 or email via hello@drprpusa.com. Or you can order a Platelet-Rich Plasma kit online and try it in your practice.

Together, let’s welcome the Anabolic Era of Medicine.

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Six Ways Platelet-Rich Plasma Saves Your Patient’s Money

In 2011, Stanford University researcher Jason L. Dragoo, reported that there are over 86,000 PRP Injections performed in the US each year. Market analysis by exerts put the growth rate of the Platelet-Rich Plasma market at almost 12% compounded rate which means that the number is probably 170,000 this year. Yes, well over 170,000 PRP injections are performed annually in the US. A recent scientific research by Russian researchers claim that patients save about US$876.84 on average when choosing Platelet-Rich Plasma over conventional treatments. This researchers included only data for PRP applied for wound healing. But we believe the savings for sports injuries and arthritis patients to be much higher. That’s a WHOPPING $149 million in COSTS SAVED BY PRP INJECTIONS in the US alone.

And we’re just scratching the surface here.

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Skyrocketed During The Past 5 Years

Stephen Clark, PT, DPT, MBA, OCS, president and founder of Athletic Physical Therapy in Los Angeles, notes that “the number of physicians performing PRP procedures has skyrocketed during the past 5 years.” This correlates to the aggressive demand we’re seeing for this safe and autologous treatment. The patients can’t find enough physicians performing the procedure. We receive inquiries from patients wanting to do the treatments and some are even willing to go out of state if there’s none in their area.

Watch this response from this patient about her PRP injections.

And patients like Ken below come back for more after their initial injection.

The science, however, is just catching up with this trend. Recent FDA-Sanctioned, Randomized, Double-blind, Placebo-controlled study and Meta-analysis of Level 1 Randomized Controlled Trials continue validating Platelet-Rich Plasma’s role as a better therapeutic tool than conventional treatments.

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Six Ways Patients Save Money When You Offer Them PRP

The big stumbling block for PRP is insurance acceptance. Right now, the insurance companies gleefully ignore the 0232T code – the CPT code for Platelet-Rich Plasma injections, with or without image guidance including its harvesting and preparation. But as they’ll soon realize, not accepting PRP injections is actually costing them a lot of money down the road. That’s why many physicians we talk to believe that it’s only a matter of time before the insurance start accepting it.

But even if it remains that patients have pay out of the pocket for these injections, it still is a very cost-efficient way for them to deal chronic injuries and degeneration.

Here are six ways we know.

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1. Symptom management vs true healing

Typical drug-based approach to healthcare is more symptom management than true healing. This is because the drugs typically do nothing to promote the reversal of the root cause. Instead, they’re good at masking the symptoms. The implications of this are vast when it comes to cost. Since the root cause is not addressed, the patient becomes dependent on the drugs as the disease progresses and symptoms recur. Each time they’re given a stronger dose or a different drug until it no longer works.

Now, compare that to Platelet-Rich Plasma’s approach to actually correct the root cause by promoting healing of the broken or degenerated tissues. Often patients are healed by just one or two injections. And they’re happy for years.

In the long run, the patient who’d had Platelet-Rich Plasma Injections are less likely to develop complications leading to surgery.

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2. Eliminate surgeries

This is huge. Analysts estimate that there are over 600 thousand knee-replacement surgeries performed every year. When people think of the cost of these surgeries, even minimally invasive ones, they only look at the hospital bill that may be covered by the insurance provider. But there are numerous other costs like loss productivity due to patient’s downtime, psychological costs, and even miscellaneous costs during the patient’s stay in the hospital.

Moreover, stuff like arthroscopic surgery, the most common orthopedic surgical procedure, has a history of leading to further deterioration and arthritis.

So the patient’s actual costs are high.

All of these are eliminated when you suggest your patients choose Platelet-Rich Plasma at an earlier stage.

3. Complications, scars or downtime

According to this paper, post-surgical complications can exceed $10,000 for each patient. That is just for surgeries. What about complications due to side effects of drugs? Research indicate that it’s about $1300 per adverse drug reactions.

In fact, medical complications and side effects are some of the biggest cost burdens associated with modern western medicine.

Then there are scars associated with surgeries. Not to talk about downtime.

Platelet-Rich Plasma on the other hand would have none of that troubles. This risk of injection is extremely low since it’s all autologous. And the procedure is done on an outpatient basis after which the patient can return to normal activities the following morning.

All of these translates to increased savings every time you recommend Platelet-Rich Plasma for your patients.

4. Multi-potential therapeutic effects

One of the problems with FDA-approved drugs is that they can only be prescribed for the stated purpose of use. A drug for arthritis patients can only be prescribed for arthritis patients even if it might help a patient with tendonitis. Thus if the patient has more than one orthopedic conditions, chances are each one will need different drugs specifically approved for that condition. Take arthritis and osteoporosis – they are treated completely different when using FDA-approved injections.

On the other hand, Platelet-Rich Plasma is multi-potential. It can be injected on…

  • Knees to heal meniscus, ACL, MCL and arthritis
  • Shoulder to heal rotator cuff tears and tendonitis
  • Hip to heal labrum and bursitis
  • Low Back to heal spinal degeneration and sciatica
  • Foot to heal Plantar Fasciitis, Achilles heel and ligament sprains
  • Elbows to heal lateral epicondylitis and medial epicondylitis
  • Bone to aid the union of fractured bones

You get the point. The possibilities are endless.

This means that the patient do not have to get an assortment of drugs if they need relief for multiple symptoms and thus there is no cost of acquiring new drugs (or potentially leaving drugs unused) each time they have a symptom.

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5. No research and marketing costs are added

This is one of the main advantage of Platelet-Rich Plasma injections. Unlike FDA-regulated drugs, for which the companies spend millions of dollars for research, several times more on marketing and mass production, there’s little capital costs involved with Platelet-Rich Plasma.

To produce it, all you will need to invest in is a good PRP Kit and a centrifuge and the patients can come and get the PRP injections unlimited number of times.

All the research on Platelet-Rich Plasma is done by independent researchers around the world and there’s one no single entity who’s licensing it. So customers aren’t paying for bloated research funding and marketing costs.

This means you can afford to charge your patients less.

6. Outpatient treatment, benefits small and independent clinics

The process of getting admitted to a hospital is mentally taxing. And most of the surgical procedures, however minimal require hospitalization. And that means you need big equipments and all sort of things. So only big hospitals can do those. There is an endless list of charges that the hospital needs to include as a standard and depending on the co-pay agreement with their insurance, the patients may end up paying anywhere from 10% to 50% of these extra unnecessary charges.

With Platelet-Rich Plasma, though, it is an outpatient treatment done in small, independent clinics as a 45-minute procedure. And these clinics are very cost-efficient in their operations because they do not need to employ a lot of staff.

The takeaway? Patients pay significantly less compared to surgeries. And the small, independent clinics have a big advantage over large hospitals.

As a last resort I had two injections of PRP

Platelet-Rich Plasma is here to stay. The skyrocketing demand is proof. And there is no reason why you shouldn’t be offering it. Thousands of cases prove that it works. We’ve shown you how it saves your patients money.

If you’re an orthopedic surgeon, rheumatologist, and/or run a pain management clinic, you’re doing a tremendous disservice to your patients if you’re not suggesting Platelet-Rich Plasma to your patients. Because Platelet-Rich Plasma has the highest adoption rate in this field – and for a reason. It has become indispensable.

The second group of people who uses PRP is aesthetic professionals followed by ophthalmic surgeons.

We’ll let some of the stories from Physicians themselves convince you about offering Platelet-Rich Plasma.

Here’s one physician who saw the value in Platelet-Rich Plasma ONLY when he himself was forced to seek the treatment.

“I am a physician who suffered with high hamstring tendinopathy which prevented me from playing competitive soccer and sprinting. I tried all conventional treatments for two years without any improvement. These included physiotherapy from a nationally recognized sports physio. I also used NSAIDs, fish oil/omega 3, glucosamine and chondroitin. I was looking at retiring from competitive sport. As a last resort I had two injections of PRP by a specialist sports physician. After three months I can now run without pain. This was a last ditch treatment that worked for me. (Although it was a trial of n=1).”

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Another dentist reports that he’s been using it for more than 8 years for grafting procedures.

PRP is very effective in bone grafting procedures with a huge amount of research supporting it’s effect in speeding healing. It’s use in tendonitis seems to be questionable. I am an oral & maxillofacial surgeon and have used it for greater than eight years with great success in my grafting procedures in the jaws.

The point is, we could go on and on and on about the reasons why a lot of physicians are excited about this treatment. It is simple and practical enough to quickly adopt it into your practice. And the risks are absolutely minimal.

Consider Getting Trained For Advanced Precision PRP Injections

That being said, you might want to undergo training for advanced prp injections at the Interventional Orthopedics foundation. Because, the ability to accurately localize the Platelet-Rich Plasma is one of the biggest needle movers when it comes to extracting the maximum therapeutic benefits. According to the foundation, only 1% of the physicians are able to do these precise injections without training. And so, chances are you may not have had the training. The Interventional Orthopedics Foundation also offer home study videos if you’re not able to attend in-person.

Six-Ways-Platelet-Rich-Plasma-PRP-Injections-Save-Money-For-Patients

And if you need help setting up your Platelet-Rich Plasma workbench, we’re here to help. Give us a call at (844) 377-7787 or drop us an email via hello@drprpusa.com. We handle everything from PRP kits to centrifuges to workspace for PRP and marketing brochures.

How to choose the best PRP Kit (Platelet-Rich Plasma) 1
How to choose the best Platelet-Rich Plasma (PRP) Kit

For an incredibly straightforward process, the science of Platelet-Rich Plasma extraction has been surrounded by scores of debating researchers for over a decade about the composition and the method. Today, we’re going to clear up all of that by helping you choose the best Platelet-Rich Plasma (PRP) kit.

How to choose the best PRP Kit

First of all let’s talk about not using a kit. Yes, you can draw blood into a test tube, centrifuge it, take the top portion and call it PRP. That’s called “bloody PRP” and it is the least effective containing maybe 1-1.5x platelets if you’re lucky – and a whole lot of Red and White Blood Cells. This is what you should not ever think of doing because it’s not the real Platelet-Rich Plasma. In some cases, this way “bloody prp” has been known to have caused post-injection flare ups.

Using a Platelet-Rich Plasma kit on the other hand, you can get a platelet concentration anywhere between 5X and 7X the average.

How to choose the best Platelet-Rich Plasma Kit

This 5X-7X concentrated serum is what is known as Platelet-Rich Plasma or Autologous Conditioned Plasma. These professional kits allow you choose to allow or disallow red and white blood cells in your final product depending on applications. For example, researchers now suggest Leukocyte-poor Platelet-Rich Plasma for osteoarthritis and Leukocyte-rich Platelet-Rich Plasma for tendinopathy applications.

However, there are some commercial kits that may not deliver exactly what you want in your PRP.

To understand that fully, here’s a diagram of the components in blood.

How to choose the best Platelet-Rich Plasma Kit

And here’s how it will segregate itself after centrifugation.

How to choose the best Platelet-Rich Plasma Kit

Based on the technique of segregation, the kits are classified into two types.

1. Gel separators

Gel separators are those that basically nothing but a special test tube with some gel inside. It works because the gel has the density that’s in between blood and platelets. So when you fill it with whole blood and spin, the platelet portion of the blood will go to one side of the gel and the blood portion on the other side. But the biggest drawback of these gel-based PRP kits is that most of the platelets will end up getting caught in the separator gel itself. Hence the 1-1.5X concentration you get when you sequester the platelet part. One positive aspect is that the gel also separates white blood cells. So the PRP obtained is has almost zero RBC and WBC.

2. Buffy coat based

The kits that produce a visible buffy coat layer after centrifugation are the best at giving concentrations of platelets anywhere from 5X to 7X. What’s a buffy coat? Buffy coat is a thin layer, neutral or buff in color, formed between the blood and the platelet serum and are essentially plasma with suspended platelets. Now, having a buffy coat by itself will not be of much use. Instead you must be able to carefully separate the buffy coat from the RBC without contamination. When separated the right way, the buffy coat will be mostly plasma and white blood cells (leukocytes) with 5X-7X platelets concentration with less than 10% RBC.

How to choose the best Platelet-Rich Plasma Kit

3. Buffy coat based, double-spin

Yes, there is a third type of Platelet-Rich Plasma kits and those are buffy-coat based and that can do double-spin without introducing further Red Blood Cells into the mix. This is the best Platelet-Rich Plasma kit you can hope to have. Because essentially what it can help you do is sequester the Plasma + Platelets mix and do a further short run spin in the centrifuge to further isolate the Platelets. This time the platelets will be accumulated at the bottom of the Plasma serum. Once this is done, all you have to do is take the bottommost portion of the serum which will be 5X to 7X concentration of Plasma. This is what is called Platelet-Rich Plasma or Autologous Conditioned Plasma.

Getting this kind of end-product is key here as researchers have identified that for clinical benefits, the Platelet-Rich Plasma needs to be 1 million platelets per μL or more. This is 5x to 7x the normal platelet count of 200,000 platelets per μL.

How to choose the best Platelet-Rich Plasma Kit

The DrPRP Kit – Probably The Best PRP Kit

There are various kits for Platelet-Rich Plasma separation. But our kit, the DrPRP kit, is special in that it uses the dynamics of the tube design to give you full control over the end-product. You can get 10cc of usable product that you can manipulate to your specific needs. You can sequester the platelet serum and double spin it for 5X-7X above baseline platelet concentration. You can get a completely amber product or red product depending on whether you want a little red blood cells in your end product or not.

Leukocyte-Poor Platelet-Rich Plasma

When you’ve gotten the Platelet-Rich Plasma, deciding on if you need Leukocyte-poor Platelet-Rich Plasma is the next step. Although there is no consensus on the presence of leukocytes, some researchers maintain that the leukocytes are inflammatory and may inhibit the power of cytokines and growth factors to create new cells. The researchers on the other side of the argument claim that without inhibitory effect of the leukocytes there will be excessive scar tissue at the healing site. Leukocytes-Rich Platelet-Rich Plasma is known to contain more growth factors like TGF (which improves collagen synthesis), PDGF (increases cell metabolism) and VEGF (assists the formation of new blood vessels).

Other studies show that Leukocyte-rich PRP is most effective in the treatment of tendinopathy while Leukocyte-poor PRP is most effective in the treatment of osteoarthritis. It’s better that you try them out both and come to your own conclusion.

In case you need to use Leukocyte-poor Platelet-Rich Plasma, you may need a Leukocyte-Reduction (LR) filter. Conventional LR filters use electrostatic attraction in micro-sized filter membrane to retain Leukocytes while allowing the rest of the components to pass through. Drawbacks of this filter include clogging of the filter membrane half-way through the filtering process. A better LR filter is based on Controlled Incremental Filtration (CIF) method. With the CIF-LR filter, you will be able to remove 99.99% of leukocytes from the Platelet-Rich Plasma.

How to choose the best Platelet-Rich Plasma Kit

The Lack Of Clinical Evidence Myth

Let’s address ignore the elephant in the room, shall we? There are some doctors who believe that Platelet-Rich Plasma is just a fad. They say, “Show me the double-blinded peer-reviewed evidence.” It’s not that the other stuff they use for their patients are all double-blind proven and peer-approved. They just want to see it for this one. It doesn’t matter that the scientists who discovered growth factors in plasma got Nobel Prize in the 1950s. It doesn’t matter that they started using Platelet-Rich Plasma to heal gums in 1970s. It doesn’t matter than there are more than 6,000 studies on it till now. Use this search query in the NIH database and you’ll spot more than 1000 of them.

The hard evidence is of course money. Why are hundreds of thousands of customers taking out hundreds of dollars out of their wallets to pay for Platelet-Rich Plasma? Why are the independent researchers worldwide spending the very little research dollars they have (compared to the big pharma research moola) on studying this treatment?

A doctor who’s reviewed over 700 PRP treatments said the treatment has over 70% satisfaction rates with over 50% patients coming back for more.

How to choose the best Platelet-Rich Plasma Kit

An Incredible Healing Story

So far, Platelet-Rich Plasma is spreading mainly through word of mouth. Many patients take it up as the treatment of last-resort and later go on to shout it over the mountains. Here is one such story.

Three years ago, Bernie (not real name) came to see an Orthopedic Surgeon for a troubled shoulder affected by OA. After trying out the usual remedies, the OS suggested a shoulder replacement surgery. He wasn’t willing to do it. But the pain became unbearable. So the OS got him to do an arthroscopy instead. Bernie came out of the “clean out” like a new person. Unfortunately, the feeling didn’t last long.

In fact, things started getting worse. He couldn’t even hang up a shirt or pick up a pile of magazines on the floor. His arm would lock down every night. And took as much as 3 painkillers every night before sleep. As days passed, things only got worse. Then someone told him to give Platelet-Rich Plasma a shot. At this point, he was considering the OS’s original recommendation for the replacement surgery. But thought he’d try Platelet-Rich Plasma before that.

Bernie was also working with a Physiotherapist at that time. Both the PT and OS said it’s doubtful that Platelet-Rich Plasma would be beneficial – not only because the OA had advanced but also because his shoulder has 3 tears and most of bones were already worn out (his humerus was basically flat.)

Anyway, they decided to give Bernie two Platelet-Rich Plasma injections. After the injections, Bernie was told to continue the painkillers as the PRP would take some time to take effect. But what Bernie experienced was something totally unexpected.

He started improving almost immediately. And stopped taking the painkillers after two nights.

In the next two months, his shoulder became problematic only on 2-3 occasions – all while performing all the activities that he couldn’t previously perform, including activities that he wouldn’t dare think of before the injections. For example, he could ride the lawn mower for more than 45 minutes.

Needless to say, both the OS and the PT was impressed.

After seven months, Bernie has reported that he’s sleeping most nights without painkillers. After about a year, Bernie came back to say he has even less pain now. He haven’t been to the PT or the OS in several months.

Now take a guess. No points for the right answer though. Do you think Bernie will recommend PRP to others?

Check out our PRP Kit here.

How to choose the best Platelet-Rich Plasma Kit

DrPRPUSA-8-POINT-PLATELET-RICH PLASMA FACELIFT
How To Perform A Low-Cost Platelet-Rich Plasma Facelift

As any face-lift-performing cosmetic surgeon quickly learns, a surgical facelift procedure is a hard-sell even for those who are desperate for it. The entire process is a challenge not just in your surgical skills but also in your knowledge of facial geometry. That’s why the simpler, more low-cost and natural procedures like Platelet-Rich Plasma Facelift has become very popular these days.

The procedure, sometimes called sexy names by fake “inventors” to extract licensing fees from you, is actually capable of delivering surgical-facelift-level results minus the side-effects, failure-risks or downtime.

More and more clients are minimizing their risks by choosing autologous materials for soft-tissue augmentation in their face – and Platelet-Rich Plasma Facelift is a proven procedure with good predictability.

For millions of Americans who admire the results of “facelift” but are very afraid of the procedure, this is a god-sent.

Why Platelet-Rich Plasma Facelift

The Platelet-Rich Plasma Facelift has many advantages over traditional facelifts but none is more enticing than that the carefree nature of the procedure — anyone can have it on a hot sunny afternoon and wake up the next day feeling like a million dollars.

  • It is a better alternative to neurotoxins like Botox
  • No allergy testing in required
  • Reasonably long lasting results (12 months or more)
  • Low cost and high-profit procedure
  • Can be combined with micro-needling and laser treatments
  • Painless and stress-free patient experience
  • Improves skin tone and texture without additional treatments
  • Completely non-invasive and no downtime

And the market rate is about $500 to $1,500 per area. A full face procedure will run into a couple of thousand dollars.

Who Is The Platelet-Rich Plasma Facelift For?

For those who want a youthful, firm yet soft look but are freaked out about the lumps with synthetic fillers or those not willing to do fat transfer surgery, Platelet-Rich Plasma Facelift is an excellent procedure. It can be used to restore volume in 8 strategic areas similar to the 8-point lift at a relatively low cost.

This procedure is suitable for patients who’re looking to reduce the appearance of…

  • Sagging or dropping face – a sign of aging related to volume loss
  • Dark circles or tired looking eyes
  • Wrinkles and sagging jowls along the mouth and jawline
  • Nasolabial folds or “laugh lines” on the corners of the mouth

When done the right way, Platelet-Rich Plasma creates a beautiful, naturally lifted look with almost zero risk for physicians as well as patients.

How To Perform a Platelet-Rich Plasma Lift

The most easiest way to do the Platelet-Rich Plasma Lift is by injecting autologous Platelet-Rich Plasma Fibrin Matrix intradermally or subdermally below the affected areas. Researchers have proven again and again that injecting PRFM works wonders for wrinkles and folds. One such study is here.

Preparation of Platelet-Rich Fibrin Matrix

Platelet-Rich Fibrin Matrix (PRFM) does not rely on host tissue fibrotic response to produce volume enhancements – therefore it has more potential to offer sustained results compared to just plain Platelet-Rich Plasma. PRFM delivers more viable, under-granulated growth-factor-loaded platelets through a three dimensional fibrin matrix.

The preparation of PRFM is simple as explained below.

Platelet-Rich Plasma Facelift

  • Load a 20cc syringe with 3cc anti-coagulant ACD-A.
  • Prime the needle until the ACD-A is at the tip of the needle.
  • Draw 17cc of the blood into the syringe. Be sure you mix the blood and ACD-A by tilting the tube up and down a couple of times.
  • Inject the blood sample into the DrPRP kit, a closed Platelet-Rich Plasma separation tube. Make sure that it is only filled till the 20cc mark on the tube and nothing more.
  • Place the filled DrPRP tube into the centrifuge and place a counterweight directly across it.
  • Set the rotation at 3400rpm and the timer for 4 minutes.
  • At the end of the run, the Platelets and the Plasma will be on the top chamber of the tube and the Red blood Cells on the other end. Push the bottom on the tube to sequester the platelets and the Plasma. The platelets will be sedimented at the bottom of the top chamber of the tube.
  • Using a 10cc syringe with a long needle take out about 6cc of the Platelet-Poor Plasma (PPP) from the top chamber slowly (without shaking it) leaving 4 cc at the base. Keep this PPP handy, you’ll need it later.
  • Shake and mix the remaining 4 cc – this is the Platelet-Rich Plasma.
  • Load and prime another 10cc syringe with the coagulation activator 0.08cc 10% Calcium Chloride. (Take a 1 cc syringe marked off in tenths, fill up four out of five little tick-marks between 0 and the first tenth mark and that’s 0.08cc)
  • Draw the 4cc Platelet-Rich Plasma into the syringe with Calcium Chloride. You have got about 4cc of PRFM now.

You can inject the PRFM with injected intra-dermally using a 30-gauge needle or sub-dermally using a 27-gauge needle within 10 minutes – this is the time period that PRFM can remain in liquid form up after coming in contact with calcium chloride.

Once injected, the combination of Calcium Chloride and body temperature will start the polymerization of Platelet-Rich Fibrin Matrix and a natural filler will be formed in the injected area.

The 8-Point Platelet-Rich Plasma Lift With PlasmaFill™

For certain clients who need a substantial increase in volume while gaining a tightened look, you can combine the Platelet-Rich Plasma Fibrin with Platelet-Rich Filler or PlasmaFill™ using this device. This device turns Platelet-Poor Plasma (the 6cc byproduct that we drew out earlier while creating Platelet-Rich Fibrin Matrix) into autologous dermal fillers in a couple of minutes.

It’s an easy to use device. Just insert the syringe filled with Platelet-Poor Plasma into one of the holes in the device, tweak the settings (if needed) and start the process. The PPP will turn into dermal fillers soon.

A couple of things to note about the Plasma Fillers.

  • The Plasma fillers should be maintained at body temperature or slightly higher because lower temperatures will make it too viscous.
  • You must first anesthetize the injection area with a 25-gauge needle containing 0.2ml of Articaine.
  • The PlasmaFiller should be injected using 1″ or shorter 23 Gauge needle or cannula through the same puncture hole. Do not use longer cannula as the material is quite thick.

The Plasma Filler can be injected into the standard 8-point areas which includes…

  • Upper cheek bone area (1 & 2): Inject here to enhance the cheek and tightens the face.
  • Tear trough and mid-face (3): Inject here to reduce the appearance of tired hollows under the eyes.
  • Nasolabial folds next to nose (4): Inject here to create a more youthful look by reducing laugh lines.
  • Corner of the mouth (5): Inject here to iron out the Marionette lines and create a happier look.
  • Lower jawbone area (6): Inject here to replace the volume in the pre-jowl area and lift the jowls.
  • Upper jawbone area (7): Inject here to increase the squareness or angle of the jaw and eliminate sagging.
  • Lower cheek or buccal area (8): Inject here to restore the natural curve and structure of the cheek.

DrPRPUSA-8-POINT-PLATELET-RICH PLASMA FACELIFT

After you’ve done the procedure, you’ll notice that combining Platelet-Rich Fibrin Matrix with Plasma Filler gives your clients a softer, more flexible outlook compared to the rigid puffy structure obtained through synthetic fillers. And since it is completely autologous your clients need not worry about firmness, swelling, lumps/bumps, bruising, itching, or dis-colouration.

The only disadvantage of Platelet-Rich Plasma Facelift

Perhaps, the only disadvantage of the Platelet-Rich Plasma Facelift is the time it takes to prepare the filling materials. The ready-made synthetic fillers and neurotoxins are a physician’s dream – just rip off the plastic and inject them – but not so much their clients. More and more Americans now prefer autologous non-surgical methods over synthetic stuff.

However, this disadvantage is more than offset by the significant cost saving this method offers. Plus the clients will actually be happy to see the work done by physician or their staff in preparing the materials. They relish looking at how their own blood is being processed and returned to their bodies to help them look younger and more attractive.

So we don’t think this is actually a disadvantage. On the contrary, it can be a huge plus point.

Platelet-Rich Plasma Facelift

The Role of Growth Factors

A significant advantage of Platelet-Rich Plasma Facelift is the presence of growth factors in the fillers. Growth factors are natural substances in the body that is capable of triggering an increase in the production of endothelial cells and fibroblasts. The Platelet-Rich Fibrin Matrix is a 3-dimensional cross-linked fibrin matrix that binds both platelets and GFs enabling a sustained release of growth factors over about 7 days.

The growth factors are one reason why we suggest you add Micro-needling as part of the Platelet-Rich Plasma Facelift – Micro-needling triggers a healing response and the influx of autologous growth factors accelerates and deepens the healing job.

Platelet-Rich Plasma Facelift

Add Micro-needling to Complete the Platelet-Rich Plasma Facelift

Add a combination of Micro-needling and topical Platelet-Rich Plasma application to the Platelet-Rich Plasma Facelift and you’ll create stunning results comparable to ANY other premium treatments in the market at a fraction of the cost. Micro-needling works by triggering the skin to enter healing mode and create a significant amount of new collagen and elastic fibers. Adding Platelet-Rich Plasma only makes the results better.

Note that it’s totally fine to have both Micro-needling + Platelet-Rich Plasma and Platelet-Rich Plasma Facelift all done on the same day as long as you do the fillers after the micro-needling.

Platelet-Rich Plasma Facelift

How does the combined procedure look like?

This combined Platelet-Rich Plasma Facelift procedure will give your clients the maximum benefits with almost no downtime. And is by far, the best non-surgical, autologous treatment you can offer your clients. PERIOD.

  • The client arrives at the appointed time, fills out the consent forms and receives local anesthetic in the treatment room. (5 minutes)
  • About 20cc or more blood is drawn from the client and injected into the DrPRP kit which is then spun in a centrifuge to get PRP and PPP. The PRP is then turned into PRFM and the PPP into Plasma Filler. (20 minutes)
  • While this is done, the client undergoes Micro-needling procedure. (15-20 minutes)
  • A small portion of the platelet serum is smeared on the just-micro-needled face. (1 minute)
  • The Plasma Filler and PRFM is then injected into the client’s face by following the 8-point facelift system. (10 minutes)
  • A peptide mask is given to soothe the client’s face. (10 minutes)
A Significant Profit Generator

The entire procedure as described above is the recipe for non-surgical autologous facelift procedure that delivers an array of benefits to the patients namely:

  • Reduce appearance of wrinkles, sun spots, unwanted veins and other signs of aging.
  • Correct minor skin imperfections, marks, acne scars and other blemishes.
  • Lift the areas with wrinkles, sagging skin or jowls.
  • Reduce the appearance of frown lines, forehead creases, nasolabial folds and thick bands in the neck.
  • Regenerate new skin on the face replacing the older damaged layers to improve complexion and smoothness.
  • Restore the natural volume in cheek, jaw and under-eye areas and tighten the entire face.

As you can see this is a complete facelift that thousands of Americans would happily pay thousands of dollars for. According to American Society for Aesthetic Plastic Surgery, just in the year 2016 alone, Americans spent a whopping $6.6 billion dollars on in-office non-surgical skin rejuvenation procedures like Photo Rejuvenation, Dermal Fillers, Skin Tightening, And Neurotoxins.

Now the Platelet-Rich Plasma Facelift as described above is a single treatment that has the potential to deliver the whole spectrum of results that Americans paid $6.6 billion for.

In other words, it’s a no-brainer that you should ride the non-surgical wave.

Typical price for this type of full facelift procedure that can be performed in an hour is about $2400. And since much of the raw materials are directly obtained from the client’s blood, you save on costs big time.

Just don’t call your procedure “vampire” or else you will receive a letter from one Dr. Runels’ claiming royalties.

Advanced Fillers Training

For those who’re unsure how to go about actually doing the treatments, we have great news. You can get certified in this and other conventional treatments by Dr. Howard Katz who has been teaching dermatologists for 30+ years on non-surgical procedures. He conducts monthly one-day intensive trainings that will make you proficient in dermal fillers, PRP, and non-surgical facelifts. Seats fill out fast. The next available training is in September and it happens in New York.

You will gain:

  • Know-how of Dr. Katz’s DentoX LIFT – a minimally invasive Facelift procedure that can significantly impact your client’s aesthetics with no discomfort or downtime.
  • Platelet-Rich Plasma Proficiency – After this training you’ll be able to get perfect concentration of PRP every single time.
  • The science of fillers: How to use different filler combinations to get deliver the results that goes beyond your clients’ expectations.
  • Proven marketing techniques to AUTOMATICALLY attract the right clients who’d happily pay for your services.
  • Complimentary access to Dr Howard Katz’s online portal that features dermal fillers refresher courses (8 credit hours – regular price $1398).
  • CE credits – you can earn up to 18 CE credits by joining this training event.
  • Training for your staff members – you can bring one of your staff members at no charge.
  • You will be allowed to work on a patient live under Dr. Katz’s supervision if the patient’s condition warrants it.
  • Patient Forms – you will get all the patient forms you need such as patient consent, history and post-operative instructions.
  • Certification – a certificate will be given for successful completion and you will be included in the certified practitioner directory.

Check out the details here.

Dentox Platelet-Rich Plasma Botox Training

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Is Amniotic Fluid A Ready-Made Alternative To Platelet-Rich Plasma?

There is no doubt that PRP is the king of orthobiologics. Nothing else can match it’s minimal side effects, it’s ease of preparation, cost efficiency and quick treatment times. However, there is one other orthobiologic substance that is showing some promise as a ready-made alternative, Amniotic Fluid.

The Amniotic Fluid had been capturing the imagination of orthobiologic scientists as early as 1938 – it’s an excellent source of highly proliferative, low immunogenic regenerative material. They also contain other nutrients, collagen, hyaluronic acids and growth factors in abundance making them ideal for promoting regeneration.

It even has stem cells with B7H4 that promotes wound repair and shows promise for growing robust, functional blood vessels as demonstrated by scientists at Rice University and Texas Children’s Hospital.

But the Amniotic Fluid that we’re talking about today does not contain any live stem cells because of the cryoprocedure used for storing it. But this actually our advantage since the FDA does not allow for stem cells to be present in any amniotic based product at this time.

How Amniotic Fluid Allografts Are Produced

Our doctors love this – it’s like readily injectable PRP. So your patients gain almost all the benefits of Platelet-Rich Plasma without having to go through the process of extracting it yourself.

This Amniotic Fluid that is used as Allograft product is harvested from pre-screened mothers who had consented to donating their Amniotic Fluid at the time of c-section delivery. The fluid is then tested again in a laboratory before preparing them in a neat, ready-to-use format that can be instantly utilised for a wide variety of healing needs.

The one thing that makes Amniotic Fluid an excellent allograft is its low immunogenicity – it does not express the Class II antigens – making it unlikely to cause an immune response in other humans. Plus, these tissues are known to be anti-inflammatory, anti-microbial and anti-adhesive just like Platelet-Rich Plasma.

And did I mention they are multipotent cells? The best candidate for use as regenerative medicine.

While Amniotic Fluid does not have the advantage of being fully autologous like Platelet-Rich Plasma, the huge amount of collagen, elastin and fibronectin in Amniotic Fluid Allograft make it an excellent orthobiologic substance for skin regeneration. It also contains the usual growth factors PDGF, VEGF, EGF, FDF and TGF-B.

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Allogen™ Amniotic Fluid Allograft

AlloGen is a new Amniotic Fluid product by New Life Regenerative Medicine that can be used intraoperatively or through injection therapies to improve chronic pain, sports injuries, arthritis, difficult to treat wounds and even the signs of aging.

Our doctors use it with Platelet-Rich Plasma to enhance the effect of the therapeutic injection. You can also combine it with hyaluronic acid, or bone marrow aspirates.

The product comes in two forms Allogen for use in hospital procedures and Allogen LI as an injectable for in-office procedures.

Allogen LI can also be used for cosmetic enhancement in conjunction with other facelift procedures.

The specifications of Allogen
Name: Allogen™
Category: Human Cell Tissue Product (FDA 361)
Constituents: Growth Factors
Cytokines
Collagen
Fibrinogen
Hyaluronic Acid
Messenger RNA
Protein
Source: Amniotic Fluid of pre-screened, consenting mothers during planned cesarean section
Shelf Life: 2 years when kept frozen at -65°C degrees to -85°C
Patient criteria: Same criteria as Platelet-Rich Plasma – most patients are eligible.
Packaging: Aseptically processed, packaged and cryopreserved (not sterile) stored on dry ice.

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We’re Excited About The Potential Of This

We believe this is an excellent alternative to Platelet-Rich Plasma for those who don’t want to invest in the equipment and kits used for PRP Injections. And for those who’re new to regenerative medicine, this provides a stepping stone towards Platelet-Rich Plasma and possibly stem cells.

We are confident that once you get hooked to the potential of regenerative medicine, you’ll never do another procedure for sports injuries, tendon/ligament repair, chronic wounds and arthritis without it.

And possibly that will save a few of your patients from having to go under the knife.

Contact Us To Get Started With Allogen

Use the contact form below for a friendly no-obligation consultation to see if Allogen can really help in your field of speciality practice. We have so much research information, practice tips and specialty-specific advice to share with you.

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Dentox Platelet-Rich Plasma Botox Training
New Live Botox, Dermal Filler And Platelet-Rich Plasma Training

If you’ve been looking to up-level your facelift strategies with Botox, Platelet-Rich Plasma Training And Dermal Fillers, we have excellent news for you.

The wonderful Dr. Katz has agreed to partner with DrPRP for a series of one-day LIVE intensive workshops (on Saturdays, the next available one is in September) on his latest Dentox X-Lift procedure. It will feature the following:

  1. Botox Training
  2. Dermal Fillers Training
  3. Platelet-Rich Plasma Training
  4. The Dentox Lift Technique Training

Learn more about the training below or click the link below to register.

About Dr Howard Katz

Dr Howard Katz is one of the top experts and visionary in the field of face lifts and dental reconstruction. His name was included on Allergan’s Botulinum toxin (Xeomin, Dysport, Botox) patent applications for dental therapies as well as gel filler (Dermal fillers) formulations and Oraverse anesthetic reversal. You can read more about Dr Howard here.

About the Platelet-Rich Plasma Training

DrPRPUSA is honored to be able to team up with Dr. Howard Katz and the team at Dentox to organize this leading edge training on Platelet-Rich Plasma and facelifts. As Dr Katz is an actual scientist-dentist-clinician named on the intellectual property for Botox and gel fillers, you can expect the best hands-on training like the kind you’ve never experienced before.

DrPRP USA Platelet-Rich Plasma Training

The is one-day intensive program offers everything you need to expand your skill set and boost your bottom line if you’re a doctor, dentist, nurse and other qualified medical professionals in the facelift industry.

It will be featuring DrPRP USA Platelet-Rich Plasma kits and DrPRP Dermal filler makers.

Here’s the registration page and full details >>

Here’s Dr. Howard Katz himself explaining the key highlight of the event:

The training includes:

Hands-On Botox Training

Practice Botox on live patients and become completely confident in properly injecting Botox and related products.

  • Learn the latest FDA-approved procedures for Botox, Dysport and Xeomin from an instructor with more than 30 years experience
  • Get the skills to bring both cosmetic and therapeutic Botox injectables to your practice
  • Gain an understanding of documentation and legal requirements
  • Pick up tips on marketing and promoting your skills for the biggest possible income boost
  • Explore how to get more from your existing clients and bring in new clients too
In-Depth Dermal Filler Training

Learn how dermal fillers can satisfy patients and help prevent and reverse the signs of aging.

  • Explore how you can create natural-looking smoothing and reduce wrinkles with carefully placed injections of dermal fillers
  • Pick up the skills necessary for using Restylane, Juvederm Ultra, Juvederm Ultra Plus and other dermal fillers
  • Understand how choosing the right products leads to be best results
  • Find out how to correct your mistakes and the mistakes of others
  • Gain all the info you need to document, market and expand your practice with dermal fillers

Platelet-Rich Plasma Training Cosmetic

Cutting-Edge Platelet Rich Plasma (PRP) Training

Get ahead of your competition by bringing innovative PRP treatment to your practice for quicker healing and less expensive cosmetic procedures.

  • Learn how a patient’s own blood can be condensed into a powerful tool for cosmetic and therapeutic purposes
  • Ways to enhance bone grafting and tissue grafting, keeping treatments/profits in-house, and greater patient satisfaction from more painless, faster healing results
  • Gain the knowledge you need to use PRP therapy in place of dermal fillers for the same results at lower cost to you
  • Examine the ways to market your new skills while complying with the law
The Exclusive Dentox LIFT

Innovated by Dr. Katz, the Dentox LIFT allows you to perform a non-surgical facelift, with stunning results in under 30 minutes. No general anesthetic is required, there is no scarring, and results last for 1-2 years. Attract new patients, and offer your current patients this treatment to enhance their cheekbones, define a youthful jawline, and smooth their under-eye areas.

PLUS More extras including:

⇒ Proven Marketing Techniques
⇒ Free Staff Member Attendance
⇒ Patient Forms
⇒ 10 Hours Continued Education Credits
⇒ Courses include free access to the live, online Botox and Dermal Fillers refresher programs (4 additional credit hours each).. up to 18 total CE credits!

DrPRP USA Platelet-Rich Plasma Training

I believe this is a unique opportunity not only to learn from one of the nation’s pioneers in the facelift industry, also to meet other cool amazing people who’re rocking it in this space so you can learn from them and drastically improve your practice or clinic bottom line.

Registration is open now – it’s all online takes about 5 minutes of your time – and seats are filling fast 🙂

You can learn more about it all here >>

 

Platelet-Rich Plasma Certification Training
5 Questions To Ask Before Offering Platelet-Rich Plasma

Almost everyone is an ideal candidate for Platelet-Rich Plasma.

PRP, with it’s more than 1 million platelets per microlitre constitution, has brought about huge relief for patients with acute joint injuries, joint pain, arthritis, torn meniscus sciatica, degenerative diseases, rotator cuff tears, ligamentous laxity… you name it. It is also injected into spinal discs for disk injection therapy, and into knee and shoulder joints for regenerative purposes.

Today, Platelet-Rich Plasma dominates fields like orthopedics, sports medicine, ophthalmology, wound healing and cosmetic enhancement.

That’s why there are 8,549 entries for Platelet-Rich Plasma in the NCBI databases. To give you a reference, acetaminophen, the #1 most prescribed drug, has about 19,741 entries.

Combining those with the fact that it’s autologous, and there’s little risk for rejection or side effects, it will seem like PRP is a universal healing agent.

Except it’s not.

There are a couple of things physicians must be careful of. Because there are times when administering PRP can be a bad decision although it’s not anywhere as complicated as a wrongly prescribed drug.

Platelet-Rich Plasma Certification Training

Here are the questions physician should ask before offering Platelet-Rich Plasma to their patients.

1. Are they free of these contraindicated conditions?

PRP happens to be one of the safest procedures out there. With PRP, you draw 20cc blood from the patient, spin it and then re-inject it to the injured area. No big deal. But as with any other injection, the basic risks of infection, pain and inflammation are still there. The blood collection, PRP processing, and activation should be done in a maximally sterile environment for the results to be accurate.

And that is if the patient is free of any of these pre-existing conditions:

  • Cancer or Metastatic disease: the blood of patients with cancer, especially hematopoietic or of bone, might be infected with the cancer cells, so PRP is not advised. Same goes for any other metastatic diseases.
  • An active local infection: if there’s an existing infection in the area to be treated, you must treat and heal the infections first before applying PRP therapy. Except for some bacterial infections which PRP’s anti-microbial properties can control.
  • Pregnant or are breastfeeding: the risk of infection (even though minor) means it’s not advised for expecting or new moms.
  • A low platelet count (thrombocytopenia): patients with platelet count less than 105/ul is not advisable since the low platelet count makes it ineffective anyway.
  • Anemia or low HGB count: patients with less than 10 g/dl of hemoglobin should not be allowed to undergo PRP as their blood may be weak.
  • Platelet dysfunction syndrome: patients with any of the five types of platelet function disorders are not recommended. It may aggravate their symptoms.
  • Antiplatelet therapy: those who are undergoing antiplatelet therapy for arterial circulation may not see any results due to lack of platelets.
  • Active Smoking Habit: smoking increases blood pressure and is said to lower platelets (not always), and so the effect of treatment may be low enough to not warrant it.
  • Alcohol Overuse: we know consuming too much alcohol can diminish body’s capacity to release stem cells so alcohol intake should be controlled or avoided before and during Platelet-Rich Plasma treatments.
  • Allergic to cows: bovine thrombin is typically the standard for initiating clotting of PRP and is derived from cows. So if the patients are allergic to cow’s products, alternatives need to be arranged.
  • Septicemia or blood infection: if the blood is infected by harmful bacteria, its effects may be amplified by doing PRP.
  • Local toxicity to Bupivacaine HCL or Lidocaine: if the patient has an allergic reaction or local toxicity to these, it could trigger an adverse reaction.
  • Corticosteroid injection and NSAIDS: patients must refrain from taking any form of corticosteroid injections for up to ONE month prior to PRP therapy. As for NSAIDS like Nurofen, Voltaren or Mobic, that period is 7-10 days.
  • Recent fever or illness: if the patient just recovered from a serious illness or fever, it may be advised to wait up to 60 days before having PRP treatment.

2. Is their condition treatable by Platelet-Rich Plasma?

First of all, the three vital factors in Platelet-Rich Plasma—growth factor levels, platelet count and activation times—will vary depending on the age and how healthy the patient is.

And so is the results. It varies from individual to individual.

Another factor to look at is the healing phase the patient is in.

Which Healing Phase Is Favorable For Platelet-Rich Plasma Treatments?

The basic mechanisms responsible for wound healing can be divided into three basic phases:

1) inflammatory

2) a proliferative phase, and

3) tissue remodeling (the longest phase).

The inflammatory phase begins immediately after a wound. This initial phase includes activation of fibrin from fibrinogen and development of a clot consisting of platelets and cross-linked fibrin strands. These platelets release a number of cytokines, growth factors and proteins that direct the wound healing.

The cytokines attract neutrophils and fibroblasts to the wound to direct the proliferative second phase of wound healing, and subsequently, attract fibroblasts which are crucial to the remodel or the third phase.

The earlier you can introduce Platelet-Rich Plasma, the stronger the effect it has on wound healing. The first two phases are obviously more favorable to the treatment because it is in those two early phases of wound healing that the cytokines and growth factors are much needed.

Which means, PRP is best administered less than 6 weeks after an acute injury before the healing slows or stops. In overuse or repetitive conditions, this time-period may be shorter.

Platelet-Rich Plasma Certification Training

That’s why we encourage physicians to use Platelet-Rich Plasma as the first-line treatment option for all healing purposes. Because, the treatment is best received in the early stages of osteoarthritis, and not only when all other options are exhausted. Our bodies naturally do that. Research shows that migration of platelets to the injured site is the first natural response of our bodies.

That being said, here are the common conditions that are known to have clinically proven benefits with Platelet-Rich Plasma treatment.

Conditions Which Can Be Treated By Platelet-Rich Plasma

Bone, Muscle And Tendon Regeneration:

If the patient’s condition will improve with bone, muscle or tendon regeneration, Platelet-Rich Plasma has a strong chance of helping. That’s why it is so popular among orthopedics. Almost all kinds of chronic tendon injuries, especially tennis elbow, Achilles Tendonitis, Rotator Cuff injuries, glenoid labral tears, hip labral tears, osteochondral lesions or inflammation of the knee patellar tendon will benefit from PRP. Even people with acute sports injuries like pulled hamstring muscles in the thigh and knee sprains benefit from it. Cartilage defects (CDs) and the most common joint disease, osteoarthritis (OA), are fantastic candidates.

And I believe every doctor has a duty to at least offer PRP to every patient suffering from these conditions, given that surgery is the only other option once conservative treatments fail.

We want to avoid surgery as much as possible.

Platelet-Rich Plasma Certification Training

Managing Healing, Recovery, and Pain:

PRP can accelerate healing and growth of bones, muscles, and tendons. So whenever there are large defects that need healing, a PRP injections can come in handy. This is true for healing after surgeries, recovery after chemotherapy, and general pain associated with age-related degeneration like back, knee and neck pain. PRP can also be used simply to improve the function of the shoulder, hip, and knees. PRP has also been used in spinal and joint fusion surgeries with success.

A skilled practitioner can administer numerous PRP injections (with varying constitutions, perhaps) depending on the severity of the condition.

Reducing aging, hair loss, and hormonal symptoms:

Platelet-Rich Plasma has become popular as a treatment for reversing aging symptoms in hands, face, neck, jawline, and décolleté including sagging jowls, thinning of the skin, puffiness, age spots, and wrinkling. Also, PRP is also considered a cosmetic medicine and is used to treat acne, scarring, eye bags, and post-pregnancy skin laxity.

The famous treatment is Platelet-Rich Plasma Facelift which is PRP combined with Microneedling where the PRP serum is directly injected into the skin through multiple tiny punctures under the dermis with or without topical local anesthesia. This stimulates the tissue and triggers a healing process; it’s the first step being a mild inflammation. The result is the production of new collagen tissues leading to a reduction of symptoms.

PRP has also shown promise to heal alopecia. It acts as fertilizer by recruiting stem cells to the hair follicles. PRP’s ability to form new blood vessels (angiogenesis) and the grow blood vessels from already-existing blood vessel tissues also helps.

Usage of Ultrasound Imaging

For PRP injections, the patient must also agree to use fluoroscopy, CT, or ultrasonography (US) for real-time visualization of the procedure.  This maximizes efficacy by guiding the needle accurately.

3. Can the patient cover out-of-pocket costs?

Platelet-Rich Plasma is still considered experimental by most insurance companies. Hence you may not be able to bill your patient’s health insurance plan for this service. However, if you’re a surgeon and use it in conjunction with surgery, PRP may be eligible for reimbursement. It’s best to ask the insurance company in advance.

Platelet-Rich Plasma Certification Training

Treatment cost can range from $200 to $2000 and in most cases patients have to bear it themselves. However, because there is no cost to actual PRP serum itself, the cost does not double or triple when more than one condition is treated. Typically the cost is calculated based on how much time it takes for the entire procedure.

Here are the insurance plans that do not cover PRP in general:

  • AETNA
  • BLUE CROSS BLUE SHIELD
  • CIGNA HEALTH PLANS
  • HEALTH NET
  • UNITED HEALTHCARE
  • MEDICARE (except when enrolled in a clinical study)
  • OXFORD HEALTH PLANS

4. Do We Have The Right Protocol?

Although the Platelet-Rich Plasma procedure is simple as it looks from the outside, there’s more science to it that meets the eye. As the saying goes, the devil is in the details. And it can have a huge impact on the outcome.

Here are further questions to ask in this aspect.

Do we have the right concentration and composition? For the results with PRP to be consistent, you need the right concentration and composition. A higher platelet concentration may not necessarily be better and in some cases can be counterproductive.

How does leukocyte-rich and leukocyte-poor PRP compare?  Do you know how leukocyte-rich and leukocyte-poor Platelet-Rich Plasma work for specific conditions? Leukocyte-rich PRP causes a more pronounced inflammatory effect than leukocyte-poor PRP and may be detrimental to the healing of tendons. Therefore, leukocyte-poor PRP is preferred for acutely injured tendons.

Which type of activation should we use? There are two types of activation that can release growth factors, endogenous or exogenous. But they both does not have the same results.

And which centrifuge and PRP system should we use? There are a lot of centrifuges and PRP systems in the market. It’s important that you know the criteria you need to pay attention to for the specific needs that you’ll be using PRP for.

Platelet-Rich Plasma Certification Training

5. Do We Have The Right Training?

As a physician, it’s your duty to be acutely aware of all the options you have with Platelet-Rich Plasma. And be able to determine the appropriate indication and contraindications for PRP use, consistent with ICMS/AMSSM standards. That’s why we suggest you attend a training course for extensive instructions.

Taking a proper course will also help you understand how to clearly communicate the risks, benefits, expected course, and follow-ups to the patient. This is assuming that as a physician, you already have a thorough understanding of graft selection and preparation of a graft with or without additive supports (calcium, thrombin, etc) as well as management of any complications.

Another important know-how that can come in handy for Platelet-Rich Plasma practitioners is pain management strategies.

Excellent Training On Platelet-Rich Plasma For Cosmetic Use

If you’ll be using Platelet-Rich Plasma for cosmetic purposes, here’s an excellent training that you can register for. It provides full training and CME credits for dermatological applications.

Platelet-Rich Plasma Certification Training

This Course also includes extensive Training on Using Micro-needling along with PRP. Known as the PRP Facelift and the PRP Facial, these are hottest trends in the skin rejuvenation arena. You’ll also get the latest research on the subject with dozens of citations and live links to full-text peer-reviewed articles on this subject.

If you want a one-stop training to add cosmetic PRP to your existing practice of BTX-A and Facial Fillers… this is your best bet.

And the best part is everything is online. You can take the course at the comfort of your own home.

Click here to learn more

Platelet-Rich Plasma Certification Training

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