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Posts Tagged : Platelet Rich Plasma

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NEW: Hands-On Injectables Training In Houston By Dr. Katz

Should You Be Using PRP Instead of Dermal Fillers?

The short answer – you should be using both! According to this journal article by Dr. Daniel Sister, combining Platelet-Rich Plasma with Hyaluronic Acid fillers delivers 100% success rate with enhanced results while minimizing the numbers of injections needed. And with the new DrPRP Plasma-Fill™ Bio-Filler Maker Machine, you can opt for 100% PRP fillers when patients request to go all-organic.

Here’s why this is important:

  1. PRP fillers are natural and organic: The dermal fillers produced by Plasma-Fill™ comes from autologous blood, so it’s 100% natural and over time, the product will dissolve into the blood stream without unwanted consequences.
  2. Enhanced skin rejuvenation: The growth factors contained in PRP are known to promote the production of collagen so its not only about volume but skin rejuvenation is a key result unlike synthetic fillers.
  3. Healthy skin, less blemishes: Being a healing agent, PRP adds a touch of healing into the mix so that if there are acne blemishes, excessive dryness or even minor scars, those are more likely see improvement giving the treatment a great value for money.
  4. Save patient’s money: Stocking big brand synthetic fillers can be very damaging to your cash-flow as well as your patient’s wallet. That’s why we’re seeing PRP filler adoption at a record rate. It’s a no-brainer. There is expensive and side-effects-prone artificial stuff and the organic and cheaper alternative for pretty much the same results. Even though we may have to rely on synthetic fillers for certain cases, the cases you opt for PRP fillers will offset the costs significantly.

Exclusive Hands-On Training For Physicians In Houston

Handling PRP dermal fillers is different compared to traditional hyaluronic acid fillers – for example, prp fillers need to handled at room temperature or higher at all times and they have to be injected with a different type of needle. And there’s more fine tuning to be done if you want consistent better results and patient satisfaction. That’s why we’re excited to partner with one of the best cosmetic surgeons in the field, Dr. Howard Katz to offer you the training you need to achieve mastery in this arena.

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Dentox offers industry-leading Botox training around the world and is now bringing its one-day seminars to Houston. Dentox courses are taught directly by Dr. Howard Katz, whose name is on the actual patent application for Botulinum Toxins (Botox, Dysport, Xeomin, etc), and is the first educator in the uses of Botox for facial aesthetics.

The class will include complete instruction on injecting Botox and Fillers for the most popular therapeutic and aesthetic treatments available. How to avoid and correct common side effects, create truly natural results, and market your services effectively are all part of the program. For several months now, Dentox in conjunction with Dr. PRP have also included platelet-rich plasma injection training, and if responses from doctors and dentists in other locations are any indication, Houston medical professionals will be thrilled with the competitive advantage provided with the use of PRP as an injectable material.

Discover The Unique, Exclusive Dentox LIFT Procedure

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Yes, you read that right. DentoX LIFT is a 30-minute non-surgical procedure that even a dentist can perform! In this training, Dr Katz will be sharing his trade secrets with you so you too can exceed your patients expectations. The DentoX lift is incredibly simple and the results stunning. You will learn how you can transform your patient’s jawline, cheekbones, lips and smile instantly with this procedure. You’ll be surprised by what you can accomplish in 30 minutes!

Invest In A Unique Training Experience

When considering whether to add platelet-rich plasma for cosmetic purposes to your medical or dental practice, it’s important to consider how you will be trained. Precision is required for a positive patient experience. Crafting and contouring is just as much art as science. Additionally, it’s important to be well-trained in managing patient expectations so they understand what’s possible and what isn’t. All of that and more is part of the new injectables program being offered by Dentox in partnership with Dr. PRP, the first of which will be held in Houston on February 24th.

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With PRP instead of dermal fillers, everyone saves – and everyone benefits. The Botox training course from Dentox is built around Dr. Howard Katz and his decades of training experience. And now, it’s also building on the power of PRP to provide excellent, affordable results.

Praise For Dr. Howard Katz

Dr. Katz is one of the foremost experts in this field of facial aesthetics. He’s an inventor named on the actual patent applications for all Botulinum Toxins including Botox, Dysport, Xeomin and Myoblock. His expertise is so in-depth, there’s little doubt that this course is going to be incredibly informative for you.

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Dr. Katz is not only an extremely valuable expert but he’s actually quite interesting to listen to. He has a simple way of imparting his knowledge in others – by the time you’re done with the training, you’ll actually feel super confident about the procedures you’ve learned. Don’t take our word for it, just ask previous students.

Here, watch these videos for a taste of what’s to come.

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Why Doctors Are Now Ditching Steroid Injections For PRP

The use of immunosuppressive biologics, non-steroidal drugs (NSAIDs) and corticosteroids, collectively known as Anti-Inflammatory Therapeutics (AIT), has been rebuked by many, including well-known MDs. But there are, still, a good majority of family doctors, pain-management specialists, and orthopedic surgeons who routinely prescribe them for arthritis, tendonitis, and bursitis because apparently, there’s no other better alternative. This is evident in the ballooning anti-inflammatory therapeutics market which is projected to reach a valuation of $100 Billion by 2020. But according to researchers, there already exists a better alternative and that is Platelet-Rich Plasma and scores of physicians are now prescribing it as a first line treatment instead of AITs.

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Why Anti-Inflammatory Therapeutics?

One of the reasons why AITs are popular is the belief that most musculoskeletal diseases are due to inflammation. It is believed that inflammation is the cause of injuries and pain. But over the years, numerous studies have shown, rather persuasively, that inflammation is a signaling process used by the body to recruit growth factors and cytokines to the tissue microenvironment. While suppressing the inflammation with drugs interrupts this natural process and provides short term relief to the symptoms, in the long run, it prevents structural healing.

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But the argument among pro-AIT physicians is that they provide the best short term relief. They claim that a short or two of AITs keeps the situation under control and is not a big deal in the larger scheme of things.

Not true. They have pain-relieving properties but not as dramatic as we may think.

First, corticosteroids are not as the ultimate pain-killers and there are other methods far superior.

Second, neither can NSAIDs be considered the most effective pain-killers and that’s a fact.

Third, the immunosuppressive biologics like DMARDS, cytokine-blockers and TNF-blockers are not effective pain-killers anyway.

But they all have one thing in common. And that is, a long-list of side effects.

The Debilitating Effects of AITs

It would have been acceptable if we could just temporarily harness the whatever little pain-relief that AITs offered while we’re looking for a favorable course of action. But that isn’t the case. Studies show that even a single dose of these AITs can lead to unwanted complications. Let’s take a deeper look.

1. Steroids
Steroids are evidently the most destructive ones. Physicians know that they must prescribe steroids very cautiously. But the problem is once they work, patients may prefer them again and again. Especially athletes who just want to get back in the arena for that final game. After all, who wants to sit on the sidelines when life passes by? Just one more time, they’ll say.

But the long term effects are disastrous. Not only are they hard to get off of, the steroids have the ability to kill mesenchymal stem cells, lead to cartilage loss, and are one of the most common causes of secondary osteoporosis. Scores of athletes and weekend warriors have used steroids to temporarily push away pain only to end up in the surgery table a few years later.

2. NSAIDS

NSAIDs are a totally different beast. Medscape reports that more than 70 million of them are prescribed to patients each year in the United States alone. This is in spite of the warning issued by the Arthritis, Rheumatism, and Aging Medical Information System (ARAMIS) against NSAID use.

To the patient, it sounds like a decent proposal – use non-steroidal drug to temporarily alleviate pain. However, the consequences are enormous. In this comprehensively researched article on the Journal of Prolotherapy, the writer calls for a total ban on the use of NSAIDs for joints owing to its potential for degenerating cartilage. This is alarming considering that majority of the NSAIDs are prescribed for joint conditions like arthritis. In another study, use of NSAIDs was shown to have tripled the progression of Knee Osteoarthritis.

Furthermore, even in the 1980s researchers have found that NSAIDs can disrupt intestinal integrity.

3. Biologics

Anti-inflammatory biologics include drugs that block pro-inflammatory cytokines like tumor necrosis factor alpha (TNF) and interlukin-6 (IL-6) as well as conventional disease-modifying antirheumatic drugs (DMARDs). The problem with these drugs is that they suppress the biologic entities responsible for the natural immunity of the body. Applying them to a joint for example, doesn’t limit its effect to that area. Instead, it suppresses these biologic entities THROUGHOUT the body including liver, colon, small intestine, bones, skin and even neurons.

That’s why they have been linked to neurological diseases, and other diseases.

Blocking pro-inflammatory cytokines are definitely a bad idea. For example, the cytokine IL-6, one of the main cytokines targeted by the new generation of Arthritis drugs is a major component of the central nervous system. So is anti-TNF drugs. Blocking these can only lead to adverse events in the long term elsewhere in the body.

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Can PRP Disrupt The Anti-Inflammatory Therapeutics Market?

Although not immediately evident, the trend for these Anti-inflammatory Therapeutics are actually going down. As researchers discover more serious side effects, the market will start shifting to more natural solutions like Platelet-Rich Plasma. In fact, it’s already happening as we speak. Even without the support of insurance companies, more and more people are opting for PRP instead of AITs. That means people are willing to pay out-of-pocket for PRP instead of accepting free drugs. In other words, the downward trend for AITs has begun.

Patients and physicians are learning the hard way that SUPPRESSION OF INFLAMMATION DOES NOT EQUAL TO HEALING.

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On the other hand, the trend for Platelet-Rich Plasma is climbing organically.

Here’s Allen Mishra’s tweet about PRP’s Google trends. Alan is the founder of the Biologic Orthopedic Society that has over 6,500 members in Linkedin.

Independent research is also catching up with Platelet-Rich Plasma. It has proved so far that PRP is far superior for:

1. Chronic low back pain

The study shows that sacroiliac joint (SIJ) injection of Platelet-Rich Plasma has a longer-lasting effect on pain than steroids. And the difference is HUGE. While efficacy of steroids was only 25% at 3 months, it was 90% for PRP.

2. Tennis Elbow

In this study, the steroids were only able to suppress symptoms for recalcitrant lateral epicondylitis, while PRP was able to biologically heal the lesion. Furthermore, the steroids caused further tendon degeneration. Another study proved that patients who had PRP shows better pain and functional improvements than patients who had corticosteroid injection.

3. Plantar fasciitis

This randomized, blinded study concluded that PRP delivered at least the same pain-relief results as steroids. Other researchers have concluded that PRP is actually more effective than steroid injection in terms of pain and functional results. Another study also proved that PRP was more effective and durable than cortisone for plantar fasciitis. Yet another British study also pointed out that PRP injections are superior to corticosteroid injections.

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4. Knee Osteoarthritis

The study above showed that intra-articular PRP injections are better than HA, ozone, and corticosteroids. Another study recently proved that PRP injections are better than Hyaluronic Acid for knee osteoarthritis.

5. Rotator Cuff Tears

This study proved that Platelet-Rich Plasma injections show benefit earlier than cortisone injections for rotator cuff tears. Another similar study also found that a single dose of PRP is better than steroid for Shoulder impingement syndrome.

Why PRP Is Actually Good For Both Patient And Physician

As you can see, the reason why more and more physicians and patients favor Platelet-Rich Plasma over Anti-inflammatory Therapeutics is that PRP not only eliminates the symptoms (pain and function) but it actually heals biologically. Yes, of course, the manufacturers of the conventional drugs would love you to believe that their billion-dollar-research-backed miracle drug is VASTLY superior to the autologous Platelet-Rich Plasma that can be produced within 10-20 minutes in a small clinic. But what we’ve seen is quite the opposite.

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One of the early pioneers of Platelet-Rich Plasma, an orthopedic surgeon Dr. Allan Mishra, M.D., says, that soon this biologic tool would be “safe, simple to use, inexpensive, and available immediately at the point of care.”

And that requires a tipping point in its adoption by physicians. It’s already accelerating at a good pace.

Dr. Mishra goes on to say that, “chronic tendinopathy is the most common indication for applying PRP in my practice. I have used the treatment for tennis elbow, patellar tendinosis, partial Achilles tendon tears and occasionally partial rotator cuff tears as a stand-alone treatment. I also now routinely augment all of my Achilles and patellar tendon repairs with PRP. And I am considering augmenting my arthroscopic rotator cuff repairs as well with PRP. For nonunions or difficult fractures, I combine PRP with bone grafting.”

For the patients, Platelet-Rich Plasma has been helping them avoid surgery for years now. See the videos below for actual testimonials from real patients.

Here’s another patient’s story of how PRP helped avoid surgery.

“When I tore my rotator cuff in 2008, I had conventional laparoscopic surgery to repair it. The outcome was excellent, but the recovery was long and horrible. The orthopedist wouldn’t let me drive for six weeks, or run, swim or lift weights for three months. I suffered through weeks of torturous physical therapy. It was nearly six months before I felt normal again.”

And the patient vowed to never go through that ever again.

Unfortunately, the patient suffered another injury in 2014.

But this time decided to try Platelet-Rich Plasma instead.

The patient said, “I had the first PRP injection on Oct. 23. It was painful, and the aching persisted for about 36 hours. I had one bad night, followed by an uncomfortable day. After that, the pain stopped. Still, my doctor advised me to baby the shoulder — to use my other arm when holding a dog leash and to skip swimming and weights for two weeks. Running was fine. He also recommended physical therapy after two weeks.”

The patient reported that by February 2015, the shoulder was 80% healed. The doctor advised the patient to have a second PRP injection to heal the remaining 20%.

Here’s what the patient said:

“I had [the second injection] on March 4. When I returned to see [the doctor] on April 12, I was feeling pretty good. No pain, no problems. He rolled in the ultrasound machine, and I was not surprised by the results.”

Watch this second video for another excellent patient story.

Get Started On Platelet-Rich Plasma Now

The best way to start making a big difference in your patients, especially if you’re an orthopedic surgeon, rheumatologist or any kind of pain management specialist, is to get going with Platelet-Rich Plasma. Don’t just have it as a back up treatment that you can try when things don’t go well. Instead, it can be used as a standard first-line treatment for musculoskeletal issues.

Give it a serious consideration.

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We can guarantee that once you start offering Platelet-Rich Plasma, you’ll end up prescribing less and less Anti-Inflammatory Therapeutics and more and more Platelet-Rich Plasma. And it will have a tremendous impact on the lives of your patients. We want to see a world where the “replacement surgeries” are a thing of the past.

And Platelet-Rich Plasma can make it happen.

Give us a call if you need more information. We can be reached at (844) 377-7787 or email via hello@drprpusa.com. Or you can order a Platelet-Rich Plasma kit online and try it in your practice.

Together, let’s welcome the Anabolic Era of Medicine.

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Why Are We Still Debating Platelet-Rich Plasma?

In the 2000s, when Platelet-Rich Plasma first started shifting its role from being a healing assistant in cardiac and orthodontic surgeries to the more leading role of healing bone grafts and joint tissues, many leading physicians claimed that the practitioners were putting profiteering before truth and science. They even said it was outright theft to charge $300 for an injection that, according to them, had an efficacy no less than placebo. That was in 2009 and the confusion back then was justifiable.

Fast forward 7 years later, in 2016, and we had the first FDA-Sanctioned, Randomized, Double-blind, Placebo-controlled Clinical Trial on Platelet-Rich Plasma for Knee Osteoarthritis which showed that PRP improved the outcome by 78% compared to 7% for placebo.

This was also confirmed by two Chinese major review studies this year, both Meta-analysis of Randomized Controlled Trials of Platelet-Rich Plasma for Knee Osteoarthritisfirst one here and the second one here.

Yet, we still see physicians here in the US – orthopedists and rheumatologists, among them – who don’t even bother to try it once on their patients!

What’s going on?

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The Hidden Factor That’s Holding PRP Back

Platelet-Rich Plasma, as we know, contains 7X-9X concentration of platelets in a serum with a balanced ratio of plasma, leukocytes and RBC. This special mixture helps supply growth factors and other proteins that tissues can use to recruit stem cells and heal itself. This process is pretty straight-forward. Yet, we know for a fact that there are some physicians who fail to see results with Platelet-Rich Plasma, including some clinical studies performed by veterans.

Are they missing something?

We suspect it has got to do with the second part to PRP’s healing mechanism. It’s right application.

It can be summed up in the following two questions.

1. Precisely which tissue are you delivering the PRP to?
2. How are you making sure that the PRP is used by the tissues and not wasted?

This is where the science of Interventional Orthopedics come into play.

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The Science Behind Interventional Orthopedics

On the outside, interventional orthopedics look very simple. You identify the area which needs healing, and then administer Platelet-Rich Plasma (or stem cells for that matter) to that particular area and wait for it to heal. Thinking that its this simple screws up the process for physicians who’re merely trying their luck with PRP. Because, the bulk of the Platelet-Rich Plasma treatment – the actual work that the physicians need to do – has to do with the following.

1) Identifying the exact group of tissues that are broken or degenerated (Accurate Localization),

2) Creating lesions in the damaged tissue, and

3) Delivering Platelet-Rich Plasma precisely at that location.

These advanced injections are much more effective and requires a different level of expertise.

For example, typical injections in the knee can only deliver the Platelet-Rich Plasma serum to the synovial fluid, synovial membrane and articular cartilage. The advanced injections like intraosseous infiltrations can deliver the PRP serum to the subchondral bone and the deep layers of cartilage that are affected by Osteoarthritis.

These kind of advanced injections require the use of fluoroscopic guidance for proper administration as well as proper training on the physician’s side.

Here’s one study that explains why accurate localization is linked with an improved clinical outcome Study of intra-articular infiltrations with intra-osseous injections of Platelet-Rich Plasma.

The thing is, not all physicians are trained to do it. The scope of these advanced injections are vast and warrant extensive training and expertise.

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To continue with the example of the knee, most physicians are proficient only in the superomedial or anteromedial/anterolateral injections to the knee. However, advanced Platelet-Rich Plasma injections can deliver the PRP to precise locations like…

  • Medial collateral ligament (MCL)
  • Posterior cruciate ligament (PCL)
  • Anterior cruciate ligament (ACL)
  • Lateral collateral ligament (LCL)
  • Patellar ligament (PL)
  • Quadriceps tendon
  • Patellar tendon
  • Medial meniscus
  • Anteromedial joint line (AMJL)
  • Medial midpatellar (MMP)
  • Superomedial patellar (SMP)
  • Anterolateral joint line (ALJL)
  • Lateral midpatellar (LMP)
  • Superolateral patellar (SLP)
  • Lateral suprapatellar bursa (LSB)
  • Infrapatellar (IFP)
  • Lateral meniscus
  • Subchondral bone
  • Femur bone

Most physicians, instead of getting highly proficient in identifying and administering precise PRP injections, they get concerned over the relative lack of protocols for PRP Injections. They get carried away by details like the frequency of the injection, the leukocyte levels, and red blood cells, when the fact is… as long as you get the platelet concentration right (5X-9X baseline), the therapeutic effects are guaranteed. The frequency and the presence of Leukocytes are minor factors that have little to no impact on the outcome.

The most important factor is physician training for advanced injections under Ultrasound or Fluoroscopy.

If It Works For Knee Osteoarthritis, It Probably Works For Other Degenerative Diseases

There is another concern among some physician who claim that there’s no evidence for the particular condition that they’re treating. For example, let’s say they’re treating Spinal muscular atrophy in a patient and see that there has been no study that proves Platelet-Rich Plasma is a good candidate.

Does that mean it won’t work? Absolutely no.

It just means no one has ever studied it in detail. The working mechanism behind Platelet-Rich Plasma is so universal that if it works for the knees, it will work for the spine and other similar areas of the body as well. In fact, there is almost no part of the body that is not currently known to have a therapeutic effect upon application of Platelet-Rich Plasma – nerves, joints, muscles, skin, hair, and even the eyes are treated by PRP.

By the way, if you’re wondering if there really is a study on Platelet-Rich Plasma for Spinal Muscular Atrophy, here is one from Egyptian researchers.

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Does Age Play A Role?

We’ve noticed that age does not have a correlation with the effectiveness of Platelet-Rich Plasma injections. It works just the same for the young and old.

However, the one thing that do have a correlation is the degree to which the disease has advanced.

The more advanced the disease, the less likely that Platelet-Rich Plasma can reverse its course. That is the reason why we recommend physicians treat Platelet-Rich Plasma as a first-line treatment for all possible conditions. It has already shown to be much more effective than both Cortisone and Hyaluronic Acid injections.

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Education in Advanced regenerative-medicine injections

So, back to the single biggest needle-mover when it comes to Platelet-Rich Plasma injections: ACCURATE LOCALIZATION. This means the physicians must undergo advanced training for this type of injections.

And there are not many options available until recently.

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Thankfully, we now have the Interventional Orthopedics Foundation (IOF) foundation – the first non-profit in the US dedicated to providing training for core injection skills. According to IOF, only 1% of the physicians in the US are trained to do these advanced injections. And chances are you may not have been trained.

With IOF, you can get trained for that in a real medical setting with skilled instructors and support staff.

According to the IOF website, they can train you on:

  • Injections for the healing of bone, tendon, ligaments, muscle or cartilage.
  • Accurate localization of these injections on damaged structures using image guidance.
  • New tools that facilitate percutaneous tissue manipulation.

This is a wonderful non-profit education initiative by Christopher J. Centeno, MD, Gregory Lutz, MD, Don Buford, MD and Richard D. Striano D.C., RMSK, all leading players in the regenerative medicine field.

Here’s a video you can watch to learn about IOF foundation.

And check out the IOF membership information here.

One last thing…

Platelet-Rich Plasma Standardization

As a Platelet-Rich Plasma practitioner, you’ll be out on the leading-edge. You’ll discover things that others may not be aware of. And you’ll have the opportunity to publish your findings. That’s when you’ll think of a standardization. By then, it’s too late. You’ve already performed a lot of injections and your data in unstandardized.

To avoid this, consider using a standard for the preparation of Platelet-Rich Plasma.

We suggest using the latest MARSPILL classification for Platelet-Rich Plasma developed jointly by Brazilian and US researchers.

The lack of standardization is the main culprit when it comes to debates over the efficacy of Platelet-Rich Plasma. We would love to see more and more researchers and everyday practitioners accepting a common standardized classification system for PRP.

Here’s the chart for the MARSPILL classification.

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And you may also want to check out the DRPRP Kit for the most ideal concentration of Platelet-Rich Plasma.

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Six Reasons To Offer Your Patients Platelet-Rich Plasma

For most musculoskeletal issues, the effects of immunosuppressants, steroids, DMARDs and protein-blocking drugs, never good to start with, usually wanes off after repeated use. And when it does, the patients realize that during the time the symptoms were being masked by these drugs, the disease was actually progressing at a steady pace. By this time though, it may already be in an advanced stage. That’s why more and more patients today are opting for natural biologics like Platelet-Rich Plasma at the earliest possible instead of waiting till all options are exhausted. This is the Self-Healing revolution.

And it’s just getting started.

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The revolution, which some doctors call “the anabolic era of medicine,” has already eliminated the need for certain traditional methods of disease-intervention like invasive joint replacement surgeries and harmful drugs for hundreds of thousands of patients. Here are some very recent patient testimonials so you can get an idea.

Catherine was diagnosed with a rotator cuff problem about 2 years ago and had trouble lifting her arm. After just two PRP injections she’s now feeling really really great. See the video below for more.

George was suffering from Plantar Fascitis which was curtailing his otherwise active lifestyle. He took a year to rehab and tried a couple of other treatments before being referred to this particular doctor for PRP injections. And again, after just two PRP Injections, the pain he’s been suffering for a year was gone.

This is another amazing story. Bodybuilder Greg had suffered a complete tear in his muscle and tendon – doctors told him his condition is untreatable and that he’d have to live with a physical deformation for the rest of his life. After two and a half months and zero progress, he decided to try Platelet-Rich Plasma. Within 16 days, it had healed and today his muscle is 100% back to normal and he’s doing training.

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Hear what he says in the video below.

Although, I am not in anyway claiming that Platelet-Rich Plasma Injection works for everyone, I do believe that almost everyone with a musculoskeletal issue is an excellent candidate for it.

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Most physicians that we talk to (see our clients list here) say they see a success rate upwards of 80% in the chapter with PRP treatments regardless of the condition they treat. In this classic book about PRP, Dr. Bittencourt et al say, in 203 cases they studied including “38 epicondylitis, 45 Achilles tendonitis, 25 patellar tendonitis, 12 hamstring origin (ischial tuberosity) tendonitis, 08 plantar fasciitis, 08 flexor carpi ulnarii tendonitis, 07 pes anserinus tendonitis, 04 biceps femoris tendonitis, 03 iliopsoas tendonitis, 06 athletic pubalgias and 06 biceps brachii tendonitis,” they saw success rates in excess of 75%.

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It’s amazing how they’re utilizing PRP Injection’s therapeutic effects across the board whether its orthopedic healing, wound management, hair regeneration, facial rejuvenation or pain-reduction. NIH says PRP works by “promoting better collagen I deposition, decreased cellularity, less vascularity, and higher glycosaminoglycan content,” whatever that may mean.

That’s why we’re seeing record growth in the Platelet-Rich Plasma market.

It has long ceased being a fad that only a group of sports medicine specialists promote because pro-athletes like Pittsburgh Steeler wide receiver Hines Ward had used it with remarkable success. And certainly has moved beyond the realm of boutique clinics. Instead, thousands of clinics all over the nation are now offering it. It is the wave of the future, still in its early-phase of saturation. And you can be one of the pioneers in the field.

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Here are six reasons why you should start offering Platelet-Rich Plasma for your patients today.

1. Clear and Obvious Results

There would be no point in discussing a treatment if it doesn’t deliver results. You only need to look at ONE SOLID STUDY LIKE THIS to conclude its efficacy because the way Platelet-Rich Plasma works is not unique to conditions treated. Meaning, if it works for tennis elbow, chances are, it will work for achilles heel too. As well as chronic wounds, spine disc regeneration, bone healing, tendinopathy and much more.

That is to say, the science behind Platelet-Rich Plasma is solid. The growth factors within platelets, mainly platelet-derived growth factor (PDGF), basic fibroblast growth factor (bFGF), transforming growth factor β (TGFβ) and vascular endothelial growth factor (VEGF) have been found again and again to be agents capable of healing tissues. PRP was initially tested by dentists in the 1990s for repair of bones after oral surgeries. Since then scores of the physicians have used it to treat the following with excellent success rates.

  • Rotator cuff injuries (study here)
  • Tennis & golfer’s elbow (study here)
  • Hamstring, hip, knee and ankle strains and sprains (study here)
  • Achilles tendinosis & plantar fasciitis (study here)
  • Knee, hip, and other joint osteoarthritis (study here)
  • Degenerative disc disease of the spine (study here)
  • Nerve injury and neurological pain (study here)
  • Chronic ulcers and post-surgical wound healing (study here)
  • Burns, skin grafts, and scar tissue remodeling (study here)

Yes, physicians have successfully used PRP to treat these conditions for OVER A DECADE now. Yet, there are some physicians who’re only now starting to see the possibilities of this autologous healing agent. They’ve been very dismissive about it until now thanks in part due to the healthcare industry’s lackadaisical approach to it.

Fortunately, much of that is changing. The future is looking bright for Platelet-Rich Plasma. A quick search in clinical trials database reveals 101 clinical trials at the time of this writing.

And it has now become a powerful force in modern medicine.

2. Simple outpatient procedure – zero down time

Preparation of Platelet-Rich Plasma is a procedure that puts the latest high-technology protein-blocking drugs to shame (more on that later) in every sense. Prepared using a simple desktop centrifuge in about 10 minutes (not including the time to draw blood), PRP delivers more therapeutic benefits than many other billion dollar drugs used for the same purpose. The entire procedure takes a maximum of 45 minutes and patients can return to their usual daily routine immediately. Plus the produced PRP is capable of remaining sterile and viable for a couple of hours.

And the safety record? Excellent, in all its use cases.

This may be one of the reasons why patients keep coming back for more once they’ve had an initial injection. The more the better they say. (We don’t agree with them though.)

3. Eliminates invasive surgeries in the long run

Platelet-Rich Plasma acts on the body in the most natural way you can think of – by triggering a healing cascade consisting of hemostasis, inflammation and proliferation phases. This is the way our bodies are designed to heal. It doesn’t aggravate the disease by blocking the natural function of cells, which is what almost all other drugs are designed to do. Therefore the earlier your patients have Platelet-Rich Plasma injections, the less likely that things will get complicated enough to warrant a surgery. We’ve heard from doctors again and again that their patients who were prescribed surgery ended up not having surgery for years.

Platelet-Rich Plasma can actually regenerate tissues, muscles, ligaments and even bones. It works like stem cells but with little less dramatic results and none of the side-effects that stem cell treatments are notorious for.

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Here’s what one of the doctors had to say.

4. The Age Of Ortho-Biologics Is Here – There’s No Escape

One of the biggest reasons why physicians don’t start offering Platelet-Rich Plasma sooner is that they mistakenly think that PRP is just a fad and it might vanish entirely a few years later. But the fact is, the biologic era of medicine is here. And Platelet-Rich Plasma is leading it. And in coming years, putting together joints and discs using steel may look primitive as more scientific data emerge in favor of Platelet-Rich Plasma. Some experts suggest that injection therapies may replace up to 70% to 80% of the surgeries in the near future.

In other words, this shift in treatment paradigm is big.

The earlier you get in, the more expertise you gain. There is a reason why some doctors get amazing results with PRP while others struggle to make it work. The reason is clear. The ones that make it work have a thorough understanding of the science behind it, and are confident about the limits and potential of the treatment. In this case, there is no substitute for experience. The sooner you start doing them, the more confident you become in PRP injection therapy. Don’t wait.

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5. No Risk Of Side Effects Or Mutagenic Effects

One of the biggest drawbacks blocking the stem cell treatments from going mainstream is the potential for the treatments to go horribly wrong. Since Platelet-Rich Plasma acts on cells via transmembrane signal cascades and doesn’t modulate the cells and their functions, there can potentially be no harmful effects from using it. That’s why you DON’T NEED FDA approval to start offering Platelet-Rich Plasma treatments.

It also means that aside from occasional patient dissatisfaction with PRP – could happen in less than 10% of the cases – there is nothing else you need to worry about. No further complications, regulatory actions, or lawsuits can arise. If it doesn’t work, fine. You can try some other treatments. Or you can even combine it with other injection treatments, provided the combination does’t negate the effects of PRP – we’re seeing a trend towards that as evidenced by this study where the therapeutic effects were doubled when PRP was added to the treatment.

That’s why your decision to start offering PRP is going to be an easy one.

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6. Low Cost Of Entry And Lower Costs For Patients

As I mentioned earlier, a very low investment in a simple desktop centrifuge like this and the PRP Kit will get you up and going with PRP injection treatments.

And you don’t have to worry about stocking up on expensive drugs or other raw materials. Your cost of goods sold is very low. That can translate to lower costs for the patient.

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But, I’m not suggesting that it will be all a smooth ride with Platelet-Rich Plasma. One of the challenges you may face is generating standardized protocols for different patient use cases. This can take a while due to trial and error – a fact evident in the current literature, where different studies follow slightly different protocols resulting in varied outcome.

So you have to use your expertise in developing protocols to maximize your results. Some factors that may come into play are the activation method, presence of red blood cells, number of spins in centrifuge, proficiency in ultrasonic image guidance, number of leukocytes and photo-activation of PRP.

You may also have to test things like Platelet-Rich Fibrin Matrix depending on your therapeutic needs.

Webinar: Intradiscal Platelet-Rich Plasma Injections

Dr. Gregory Lutz is one of the early pioneers in Platelet-Rich Plasma – he is the author of a prospective, double-blind, randomized controlled study on lumbar intradiskal PRP injections. And here in the video below, Dr. Lutz discusses his experience and provides case examples for PRP treatments.

PRP Vs The Latest FDA-approved $1 Billion Arthritis Drug

This past May(2017), the FDA approved a drug known as Kevzara – an interleukin-6 receptor (IL-6R) blocker. According to the reports, this drug costs patients (or their insurance providers) $39,000 a year and is expected to generate upwards of $1 billion in revenue for the licensing company by the year 2023. This is a drug that offers at best a temporary 66% improvement in signs and symptoms when using with another DMARD – and carries a risk of producing serious immunological disorders as the drug affects the immune system.

Now, in contrast, the autologous, non-immunogenic Platelet-Rich Plasma needs only a couple of injections that has no side effects – all of it produced from a little desktop centrifuge at your local office. No patent licensing fees involved. Sure, the patient has to pay a couple hundred bucks out of pocket, but which one do you think an informed patient will choose?

Come join the revolution by getting started with Platelet-Rich Plasma. Click here or call us at (844) 377-7787 to talk to us. We’ll support you in the setup and marketing of PRP.

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Three PRP Treatments Revolutionizing Skincare
Three PRP Treatments That Are Revolutionizing Skincare

While there are thousands of skincare centers nationwide offering at least one PRP treatment for their customers, most of them doesn’t go beyond the PRP Micro-needling treatment popularized by Kim Kardashian. The reason is – it is the simplest of all Platelet-Rich Plasma aesthetic treatments around and also the most sought-after treatment. This is all good until they realize the immense potential of PRP treatments. What they’re missing out on is the fact that once you’ve made the investment for Platelet-Rich Plasma which includes a centrifuge, PRP kits and staff training, they can start offering a whole suite of treatments for their clients.

Three PRP Treatments Revolutionizing Skincare

Platelet-Rich Plasma’s Quiet Revolution In The Skincare World

One great thing about PRP treatments is that the protocol for obtaining high quality Platelet-Rich Plasma is the same regardless of its application. Whether its joint injuries, osteoarthritis, bone healing, spinal disc regeneration or skin rejuvenation, the process is the same: draw up to 20cc blood from the patient, place it into the centrifuge which concentrates the platelets and then draw out the Platelet-Rich Plasma for immediate application. This simple process coupled with PRP’s vast scope of healing makes it one of the most significant advances in modern medicine. In fact, one physician, Dr. Lewis Maharam M.D. aka The Running Doc, who regularly writes for New York Daily News calls it “the greatest innovation since the invention of MRI.”

That applies to skincare as well. The Platelet-Rich Plasma you obtain from your clients can be used for a number of treatments, the demand for which are only growing. Here are a few ideas – these are probably the most popular/cutting-edge PRP treatments performed by dermatologists and plastic surgeons.

1. Facial Skin Augmentation With Fillers

The topical application of Platelet-Rich Plasma with Micro-needling can help regenerate the degrading skin cells and promote collagen production to keep skin plump and supple. This basic process may be enough for some of your clients. But those who’re looking for more than just skin rejuvenation, you may have to go deeper. To augment the face with natural, feminine volume, you’re going to have to inject Platelet-Rich Plasma deeper into the dermis. This will supply the growth factors to the degraded dermal tissues under the surface.

For volume though, you’ll need a filler. You can either go for a Platelet-Poor Plasma (PPP) based filler (PPP is the left-over from the Platelet-Rich Plasma process – you can read about the process in detail here.) or you can use any Hyaluronic Acid filler like Restylane Lyft.

This combination injection treatment has been proven to work well. One study by Dr. Daniel Sister analyzes the effect of a combination of platelet rich plasma, hyaluronic acid, and succinic acid for facial augmentation. The treatment showed 100% success rate.

The combination treatment seems to be evolving into a new standard in facial augmentation. It’s definitely seeing growing demand.

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2. RePigmentation And Vitiligo Correction With CO2 Laser

Companies spend millions of dollars on research to turn defective cells healthy and to increase the skin’s collagen production. They are looking into DNA technology to pull this off. But adding Platelet-Rich Plasma to existing treatment methods may be a simple and effective way to achieve the same results. Scientists from Cairo, Egypt had recently proven that adding PRP injections to fractional CO2 laser treatment for correcting vitiligo can boost the results by 4X compared to just using the laser alone. This is great news because given that CO2 laser can also be used to treat facial wrinkles, age spots, and acne scars, it seems we can significantly boost the results by combining it with PRP injections.

And if PRP is capable of boosting the effects of CO2 lasers, chances are, it can do the same for some of the other facial resurfacing treatments that you already offer your clients. Isn’t that an amazing opportunity… to offer the same treatments you’ve been administering for years – but only this time it’s significantly more effective with a secret biologic hack? Hundreds of skincare clinics are just doing that. It’s time to get on the bandwagon and start surprising your clients.

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As one of our friend-clinic owner says, PRP treatments have been a big boon to the business (PRP treatment has a 100% “worth it” rating on real self) as even people who’d had total skin resurfacing have responded well with it.

3. Hair Rejuvenation With Auto-injection

Mesotherapy is a well-known treatment that uses painless micro-injections for delivering active ingredients evenly to skin surface. This novel procedure has a reputation for improving the quality results obtained by traditional skin rejuvenation substances like vitamins and peptides. And as many skincare clinics have discovered, there could never have been a more synergistic technology than this for Platelet-Rich Plasma. The Meso Gun, as we call it, can be used to deliver an even amount of Platelet-Rich Plasma to the face, neck, chest, and hands for rejuvenation and reduction of wrinkles and discoloration, to thighs and tummy for treatment of cellulite and stretch marks, and to the scalp for the treatment of hair loss.

The big winner from this pairing of technologies is the hair loss treatment. Platelet-Rich Plasma when administered on the scalp using Mesotherapy works as an “elixir for hair growth” – and here’s a recent peer-reviewed study on Stemcell investigation journal that confirms this. Hair loss treatment is one of the examples where PRP treatment has exceeded the expectations set by the industry.

That’s why we believe this is one of the treatments that every skincare clinic should offer. Hair-loss and thinning of hair affects both men and women and is one of the most popular cause of worry for your clients. It complements the skincare treatments you offer and you’ll see many of your clients thanking you for that.

Contact us at (844) 377-7787 for more information on the Mesotherapy gun.

If You’ve Never Heard Of These PRP Treatments

Some of these treatments are so new – you may have never heard of them before. And that’s a sign that you should offer them immediately. If you have joined the Platelet-Rich Plasma bandwagon, it’s only intuitive to expand your offerings from just a PRP-micro-needling treatment to these in-demand procedures. You can do this with very little changes, if any, to your existing Platelet-Rich Plasma setup. And chances are they will pair well with other treatments you offer whether it’s Kybella injections, Photo laser treatments or dermal fillers.

And if you aren’t offering Platelet-Rich Plasma yet, this post illustrates a whole lot of reasons why you should be. The demand is only getting stronger. The earlier you join, the more you’re likely to prosper from this incredible breakthrough of modern medical science.

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Are You Maximizing Your Clinic’s Potential With PRP?

If you’re getting started right now, give us a call at (844) 377-7787 or head on to our shop to setup your clinic with the right things for Platelet-Rich Plasma. Our proprietary PRP kit makes the Platelet-Rich Plasma extraction process super efficient and produces high quality PRP in far less time than it would take otherwise. You can read more about our PRP Kits here.

Platelet-Rich Plasma is the blockchain of self-healing and it’s here to stay. It will become best friends with almost every aging man and woman either through their need to reverse aging effects or the need to heal musculoskeletal issues. And both group of people will start putting trust in it once they’ve had a chance to try it. That’s why demand for PRP has skyrocketed organically – without the big pharma advertising dollars – over the past few years.

The question is, are you willing to seize its potential?

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How Platelet-Rich Plasma Is Changing Arthritis Treatments

From a mere 6% in 1940, the rate of knee arthritis in our nation has jumped to almost 16% to become one of the top causes of disability. The consequences are paramount as arthritis doesn’t just affect knees – it overpowers people with fatigue, pain, depression and even difficulty getting out of bed. Over the past few years, Platelet-Rich Plasma has quietly emerged as a
savior for many of these patients. It ushered in the anabolic era of treating Arthritis.

Of course, this coincides with Platelet-Rich Plasma’s skyrocketing adoption rate and it’s media popularity. In fact, it has become so popular that, there is even a research paper about it’s popularity!

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How Platelet-Rich Plasma Is Changing Arthritis Treatments

Traditionally, the only road available for chronic knee arthritis patients was the road to total knee replacement. It will start out with the administration of corticosteroid injections. After going through that for quite a bit, the patient will show no further progress and the surgeon would suggest knee arthroscopy for debridement of affected tissues. That would feel better for a while before the patient returns for more. The surgeon would then give them a date for total knee replacement.

All of that has changed with Platelet-Rich Plasma and Stem cell treatments. Now, we have found out that the best bet we have is to administer Platelet-Rich Plasma at the earliest stages of knee arthritis to regenerate the affected tissues as soon as possible. Platelet-Rich Plasma, with its growth factors and cytokines, not only relieves the symptoms but it is proven to reverse the condition as time goes by. It creates a very beneficial, positive cellular change in the joint pathology.

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All of that without the adverse effects of an invasive surgery.

Proven Regeneration Tool Abandoned By The Big Pharma

Right now, Platelet-Rich Plasma is used for a number of musculoskeletal conditions like Rotator cuff injuries, Tennis and golfer’s elbow, Ligament strains, Knee instability, Chronic back pain, Knee and Achilles tendonitis and more. There is no adverse effects or long term implications. Few other treatments can match this record. The important distinction to be made when comparing Platelet-Rich Plasma with other existing treatments is its regeneration potential. Injecting PRP doesn’t just correct the condition – it has the potential to make it a little better than before. As far as research is concerned, most of the PRP literature concerns around knee osteoarthritis. Here’s a Level 4 systematic review and a more recent Level 1 systematic review of 10 studies with a total of 1069 patients if you want to verify the results.

Of course, it doesn’t mean all you need is a couple of PRP Injections and things will be better. Or maybe that’s it?

If the big pharma is able to package this and market, they would’ve carved out a multi-billion dollar market by now. But they can’t because the primary raw material – blood – has to be autologous and fresh for this to work efficiently. Some researchers are exploring the possibility of freeze-drying Platelet-Rich Plasma. This may or may not work depending on how well it can preserve the key elements of Platelet-Rich Plasma – the bioactive proteins in the platelets, plasma and white blood cells.

According to Bert Mandelbaum, MD, DHL (Hon), Chairman of Santa Monica Orthopaedic & Sports Medicine Foundation and Co-Chair of Medical Affairs at the Institute of Sports Sciences, Cedars-Sinai, Platelet-Rich Plasma is more promising than stem cells. See his recent article in Medscape here.

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Still there are plenty of doctors who comes to us asking, “Where is the research? The FDA-cleared prospective, multi-center, sham-controlled, randomized, double-blind clinical trials?” Actually, the FDA is hard at work clearing devices that provide relief of pain and symptoms associated with knee osteoarthritis (OA) for up to 90 days by nitro-freezing the nerves!

Many Research, Many Doctors

The amount of research from independent research institutes around the world on Platelet-Rich Plasma is just a tad bit overwhelming. New findings are published almost every month on the topic. The vast number of research mirrors the immense potential of PRP Injections. And for knee osteoarthritis, there is already unquestionable proof.

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Here are some of the advocates of Platelet-Rich Plasma:

  1. Caring Medical’s Ross Hauser, MD has written a well-researched article about Platelet-Rich Plasma for knee osteoarthritis here.
  2. Dr. Lewis G. Maharam, MD, FACSM, one of the world’s most extensively credentialed and well-known sports health experts known as Running Doc™, always show great enthusiasm when describing Platelet-Rich Plasma.
  3. Best selling author and team physician of Philadelphia 76ers, Dr. Nicholas DiNubile MD recently wrote an article saying Platelet-Rich Plasma may make knee-replacement surgeries a thing of the past.
  4. Famous Long Island physician Dr. David J. Weissberg, MD, says for his patients, with just one shot of PRP, in general, gets relief from their problems without any need for surgery and slow but progressive cure in their problems.
  5. Dr.Kevin F. Darr, M.D., a national leader in orthopedic medicine and a visionary in cell therapy, combines PRP with other cell therapies and finds the results “outstanding.” Dr. Darr is one of the fifteen physicians selected to participate
    in an FDA approved Level 1 clinical study utilizing cell therapy techniques. Here’s a recent testimonial from one of his patients.

Of course, there are many more. But for those who’re skeptical in trying Platelet-Rich Plasma or even offering them to their patients – a doctor once told me he’s skeptical because he might appear as a greedy physician to his patient if he offered unproven techniques for the sake of trying it – they can rest assured that many nationally reputed doctors are ardent fans of this therapy. Plus, there’s really no risk in trying it.

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The Best Approach For Skeptical Doctors

We know many of your patients rely on medical insurance coverage for their osteoarthritis and other treatments. And many of them are pensioners. Asking them to pay out of their pockets for a treatment that you yourself have doubts in – that’s impossible. While we hope the insurance starts accepting it, we can’t just ignore the results. You’ve seen the research, and heard the testimonials and read the media pieces.

So instead of wondering whether it might work – why not give your patients a try. Give the first treatment for FREE. Yes, I’m suggesting you let your patients try it out for FREE.

From what we’ve seen so far, once patients clearly experience the healing results – they’ll come back for more and you’ll more than make up for the FREE treatment you provided them.

We’ve seen over and over again – in several clinics – that patients always come back for more.

Like this case from Dr. Payel Banik’s office. (Dr. Payel is the owner of Osteopathic Healing Hands, Houston, TX.) The patient in the video below explains why he’d come back for more.

Offer Your Patients A Free Platelet-Rich Plasma Injection

So what do think? Are you going to stand on the lines and watch until government regulatory boards mandate PRP for osteoarthritis and other conditions? Or are you going to start helping your patients right now? Start offering it for FREE so that YOU will be convinced that it works. And win over your patients in the process. And watch them come back for more.

The choice is yours.

If you’re seeing a lot of patients with intermediate to advanced stages of osteoarthritis or other similar musculoskeletal conditions, offer them a FREE Platelet-Rich Plasma injection starting today. We’re very confident that it will make the fall in love with this treatment for life! There will be plenty of referrals for you.

All you need is a PRP Kit and a compatible centrifuge and you’re good to go. Call us at (844) 377-7787 if you need more info.

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The Orthopedic Surgeons Guide To Platelet-Rich Plasma

According to the famous sports medicine expert, Brian J. Cole, M.D., M.B.A., a good orthopedic surgeon is one who works hard to prevent his/her patients from going under the scalpel. To this end, he advocates a lot of contemporary thinking and treatments like Platelet-Rich Plasma rather than the usual MRI-driven surgical procedures. And we’re seeing more and more orthopedic surgeons who are following the cues of the people like Dr. Cole and are genuinely astounded by the sheer number of surgeries they could avoid by a little poking around with alternative treatments.

“The art of medicine consists of amusing the patient while nature cures the disease.”
~Voltaire

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A Little Late to The Regenerative Game?

Generally speaking, orthopedic specialists have been hesitant in adopting regenerative therapies. They’ve been relying on visual technologies like MRI machines a tad bit too much and hence accustomed to “seeing” in order to believe it. But regenerative therapies like Platelet-Rich Plasma doesn’t work that way. One has to believe in it to see the results. You can’t half-heartedly try PRP injections and give up if it doesn’t work. In our opinion, that’s what separates a passionate orthopedic surgeon from a “just doing my job” orthopedic surgeon. The former has a lot of belief in the rather invisible but non-surgical options. As the saying goes, “All surgeons know how to operate, a good surgeon knows when to operate, but a great surgeon knows when not to operate.”

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And no doubt, one of the key treatment options in Orthopedics that ends up actually saving a lot of patients from going under the knife (and has since become a powerful force in medicine) is Platelet-Rich Plasma. Of course, we’re biased but there is probably no other medical discovery in the modern medical history that has as much an impact on the medical industry as Platelet-Rich Plasma. Physicians now prescribe it as first-line treatment for a variety of medical conditions. And although Plastic surgeons are leading the way in pioneering its application, we believe the nature of PRP is such that it will eventually be of massive benefit in Orthopedics than any other field.

Another reason is runners. They constitute a good portion of the orthopedic surgeon’s patients. These patients do not have life-threateningly serious conditions. They might have minor pain or discomfort that prevents them from enjoying their daily run. They just want to be able to run again. The great news is, a single shot of Platelet-Rich Plasma can do wonders for them.

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Evidence-Based PRP Treatments In Orthopedics

Although few physicians question the efficacy of Platelet-Rich Plasma for joint diseases like knee arthritis, there are well-meaning physicians who resist recommending it to their patients lest they end up wasting the patient’s money. We regularly receive enquiries from such physicians asking for “hard evidence” of PRP’s efficacy. We know that skepticism is natural. And that’s why we’re doing our best to educate physicians so they can come to their own conclusion about Platelet-Rich Plasma.

The truth is there has been more evidence than we can handle.

Let’s take a look at a few of them.

Arthritis

Platelet-Rich Plasma is huge in arthritis. Earlier this year, researchers from Shanghai, China published a review of the 14 existing randomized controlled trials related to PRP treatment of knee-OA that comprised a total of 1423 participants. And they concluded that Platelet-Rich Plasma could be more efficacious than HA, ozone, and corticosteroids in terms of pain relief and functional improvement at 3, 6 and 12 months follow-up. This justifies why some physicians are confident enough to use PRP injections as first-line treatments for all osteoarthritis cases.

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And just recently, Spanish researchers took the next step. They tested an advanced method of Platelet-Rich Plasma infiltration for treating severe hip osteoarthritis and found that the technique extended the distribution of PRP and improved its efficacy. Simultaneously, another Spanish study established that a single PRP injection can be effective in treating late-stage knee OA. This is really really great news. Because if you’re physician dealing with arthritis patients, you probably have never seen any treatment that is this simple which has long-term therapeutic effects like that.

However, on the standardization of the PRP treatment itself, there has been no major progress except that most of the research agrees that a concentration of 1,000,000 platelets per µl (or 5X-7X above baseline) is required for therapeutic effect. This can be obtained through buffy-coat based double-spin process similar to the one followed by Dr. PRP Kits.

Some researchers have suggested using Leukocyte-poor PRP for Osteoarthritis but there isn’t enough evidence to support the notion that having less leukocytes enhances OA treatment results. In fact, there are some RCTs like this that used leucocyte-poor PRP that have failed to produce significant results while leukocyte-rich PRP had a beneficial effect as evidenced by this study.

Bone regeneration

Bone regeneration is a little-known field of medicine where Platelet-Rich Plasma has been quietly performing well. In a 2014 study, researchers concluded that there is little doubt that PRP can be beneficial for bone regeneration. But the mechanism through which PRP was able to achieve this is still largely unknown. Recently, researchers in Japan has discovered that a combination of Bone Marrow Stem Cells and PRP appeared to enhance bone formation in mice. Another RCT by Iranian researchers suggested using PRP along with autologous bone graft for long bone non-union fractures.

Platelet-Rich Plasma has also been compared with bone marrow aspirate (BMAC) concentrate by Japanese researchers and they found that PRP has almost the same capability for bone regeneration as BMAC. This is significant considering the simplicity of PRP extraction vs BMAC extraction.

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There is another meta-analysis by Korean researchers that looked at the effect of Platelet-Rich Plasma on Sinus Bone Graft. Again, the study concluded by saying PRP is beneficial.

Muscle, ligament and tendon regeneration

Historically, tendons are known to respond well to Platelet-Rich Plasma. And this review of current literature confirms the fact. This review also concluded that Leukocyte-Rich PRP (the normal PRP) was more ideal for intratendinous injections.

Platelet-Rich Plasma also has a long history with tennis elbow and Rotator cuff injuries. Researchers in China looked at 8 randomized controlled trials (RCTs) that involved 511 patients with tennis elbow and came to the conclusion that PRP is a more ideal treatment than steroids.

But PRP’s relationship with Rotator cuff injuries suffered a setback last year when a Chinese review concluded that PRP is not beneficial. Prior to that, AAOS had reported that it might be beneficial.

Spine regeneration

Intervertebral disc degeneration is one of the leading causes of lower back pain and is usually the one of the most expensive conditions to be treated – mainly due to the complexity of the condition. In one case we know, a patient with degenerative disc condition in both his lumbar and cervical spine – he had both a degenerative bulging disc at L4 and a sacroiliac joint dysfunction – was still pain-free 2 years after his doctor administered 2 PRP injections. But for this post, let’s put anecdotes aside and look at latest studies like this by Chinese researchers which seems to support the notion that PRP is indeed beneficial for retarding intervertebral disc degeneration.

Another study by researchers in New York also found that PRP is beneficial in the treatment of degenerative intervertebral discs.

Over 100 active clinical trials on Platelet-Rich Plasma

What we’ve presented here is only a fraction of the literature available. As you can see, this is an interesting time of development for Platelet-Rich Plasma. It continues to be of great interest to medical researchers and the patient population. Though the scientific community is torn apart by the lack of standardization and “hard evidence” for PRP treatments, patients are showing huge interest in it even though they have to pay out-of-pocket for these injections. And the reason why patients are voting with their wallets for this treatment is because 1) it’s simple and highly practical and 2) lot of anecdotal evidence. The research community is trying hard to catch up to these patients’ belief – there are currently over 100 active clinical trials on Platelet-Rich Plasma – and we believe it’s only a matter of time before they succeed in their quest. The lack of funding is only major hurdle the research community has to overcome before they uncover the full therapeutic effects of Platelet-Rich Plasma. And we’re excited and so should you because it’s great news for your patients.

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But for now, there’s plenty of evidence to suggest that Platelet-Rich Plasma treatments can be a standard regimen for treatment of musculoskeletal disorders. In the coming years, you will see more standardization in PRP preparation, concentration, pre-activation, injection volume, injection frequency and post-injection protocols.

The Cost Effectiveness of Platelet-Rich Plasma

One other thing to keep in mind, when weighing on the pros and cons of offering Platelet-Rich Plasma to your patients is the cost-effectiveness. Yes, you may not want to waste your patient’s money. But Platelet-Rich Plasma is something that has enormous upside with a relatively low downside. This is especially true when compared to surgical intervention. Average cost of the highly invasive arthroscopic debridement, for example, is $5000. But the same results may be obtained by 3 shots of PRP that costs $1000. The amount of improvement reported by patients undergoing both is similar – about 50%. That’s $20 for every percentage point improvement vs $100 for every percentage improvement in the case of arthroscopy. Even if the patients have to pay out-of-pocket for PRP injections, that’s not a good reason why they should not try Platelet-Rich Plasma.

Check out our Platelet-Rich Plasma kits here.

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The Osteopathic Physician’s Guide to Platelet-Rich Plasma

Even though they’re licensed to perform surgeries, Osteopathic Physicians are primarily trained to keep their patient’s treatments as non-surgical as possible. Furthermore, their philosophy leans towards prevention and overall wellness than on treating diseases. And for these reasons, we believe Platelet-Rich Plasma is one of the best treatment options they have. After all, the Osteopathic profession was founded on the basis of the human body’s innate capacity to heal itself – the very function PRP injections perform.

The Journal of American Osteopathic Association reviewed Platelet-Rich Plasma a while ago and concluded that more studies are needed. Later another study was presented about a surprising case of an 18-year-old high school football player’s rapid healing of muscle injury through Platelet-Rich Plasma. So even though PRP injections are not officially heralded as the future, Osteopathic Physicians stand to gain much, much more than from Platelet-Rich Plasma than others.

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Platelet-Rich Plasma, An Osteopathic Physician’s Best Ally?

Here’s why we think PRP Injections is probably the best treatment to arrive in Osteopathic Physicians hand.

1. PRP is holistic.

Osteopathic Physicians love treating the whole patient, rather than just the disease. And so is Platelet-Rich Plasma, which merely utilizes the body’s own healing mechanism. And it’s not aimed at eliminating just one symptom either. It heals entire areas – this is evident in cases where multiple symptoms are eliminated after administering PRP. For example, there are many cases where female patients experienced sexual revival after being treated with PRP injections for urinary stress incontinence. So even though PRP Injections were pioneered by allopathic doctors – who still are some of its best advocates – Platelet-Rich Plasma basically functions like an Osteopathic medicine. That’s why we think it’s one of the best allies of an Osteopathic Physician.

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2. PRP is a musculoskeletal hero

Depending on the specialization of the Osteopathic Physician, chronic musculoskeletal pain can be one of major issues that they deal with. And we know PRP Injections are slowly becoming the first-line treatments for musculoskeletal issues. For example, some researchers believe PRP should be first-line treatment for Knee Meniscus issues. Last year (2016), Dr Patrick Smith from the University of Missouri, Columbia, published the results of an FDA-Sanctioned, Randomized, Double-blind, Placebo-controlled Clinical Trial on Platelet-Rich Plasma for Knee Osteoarthritis – and they concluded that PRP provided safe and quantifiable benefits. Here’s another systematic review summarizing about 29 of those studies.

3. Limitless potential of PRP is hard to ignore

There is a third reason why all physicians, let alone Osteopathic Physicians, must get acquainted with PRP Injections – and that is PRP’s vast scope of application. Because Platelet-Rich Plasma’s mechanism is generic (and straightforward), it can be safely assumed that if it works on knees, it can work on any joints, muscles, tendons, bones etc. It’s only a matter of time that PRP Injections will be a standard first-line treatment for all musculoskeletal issues. If you’re keen on hard evidence, have a look at these the randomized trials as well as other studies in the NCBI database.

This limitless potential is especially a boon for Osteopathic Physicians as they look at problems through their Unity of Function lens. Because if there is a strain for a patient on the wrist, there may be other areas of the FASCIA that might be linked to the trouble on the arm. In cases like these, multiple Platelet-Rich Plasma injections on different areas can significantly enhance the typical Osteopathic treatments for restoration of balance and freedom to the entire body.

Dr. Peter Lewis, a fellow of the American Academy of Regenerative Medicine, and the clinical director of the Surecell Group, who’s administered over 100,000 PRP injections to 12,000 patients says, “More than 80% of the patients who undergo PRP treatments enjoy very good results. Even people who’ve been told they’d need surgery have a 70% chance that Platelet-Rich Plasma will help them.”

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List of conditions treated by Platelet-Rich Plasma [INFOGRAPHIC]

For your reference, we’ve included a nice INFOGRAPHIC here that lists common PRP treatment areas.

(Click here to download high-resolution version)

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Are these treatments FDA-Approved?

At the time of writing, Platelet-Rich Plasma treatments are not subject to FDA approval. Because all of these treatments are performed on the same day with minimal manipulation of the patient’s blood. This feature places the PRP procedure within the FDA Code of Federal Regulation (CFR) title 21 Part 1270 1271.1 and as such it enjoys exemption. (FDA rule in 1271.15 (b)).

So no, you do not have to follow the traditional FDA regulatory pathway.

If you need more help, call us at (844) 377-7787. Or check out our Platelet-Rich Plasma store.

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5 Ways Platelet-Rich Plasma Is Relieving Pain in America

Few things are as life-shrinking as chronic pain. Health economists report that chronic pain costs our nation more than $635 billion each year in medical treatment and lost productivity – more than cancer, heart disease and diabetes. Painkillers have been the only relief medication in modern history. That’s changing with Platelet-Rich Plasma. It has been emerging as one of the key players in pain management.

In any life that’s exclusively ruled by pain, Platelet-Rich Plasma has the power to bring back pleasure and normalcy. It’s certainly a better option for those who’re getting by on four or five Advils a day and wondering what the long term consequences would be.

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First of all, Platelet-Rich Plasma injections are completely safe. The PRP, prepared by centrifuging the patient’s blood in a special blood tube, works in a two step way. First the injections, often guided by ultrasound, breaks up the tissues and second, the growth factors in the PRP helps rebuild the entire tissue. This produces a healing effect and reduces pain.

Here are five common types of pain that can be healed with Platelet-Rich Plasma.

1. Arthritis pain

It’s been well-proven that a few shots of Platelet-Rich Plasma can produce a huge effect for Arthritis patients. It has the potential to…

  • Inhibit inflammation and thus slowing down degeneration
  • Stimulate cartilage formation
  • Kickstart the production of lubricating fluid

These activities in the affected site ends up reducing the pain sensation.

As a long term effect, Platelet-Rich Plasma injections tend to preserve the joints in more than 70% of the cases – as reported by a landmark study in 2013. Recent studies have shown similar results too. They discovered that a two or three injection treatment over a period of 4-6 weeks with Platelet-Rich Plasma does more benefit that similar injection treatments with either Corticosteroids or Hyaluronic Acid. Moreover, the cartilage degeneration was significantly slowed even for patients in advanced stages of Osteoarthritis.

The researchers also conclude that repeating the injections after 6 months ensured better results.

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2. Neurological pain

Platelet-Rich Plasma is one heck of a wonder treatment whose healing potential seems to be expanding everyday and seems like it’s only limited by the physician’s imagination. The latest of those new discoveries is in the field of nerve regeneration and the resulting neuropathic pain. Nerve fibers consisting of neurons are very delicate structures and not much has been discovered about its operating mechanism. But recently, platelet rich plasma have been shown to promote the restoration of nerve fibers.

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In a study performed at Hasanuddin University in Indonesia, Platelet-Rich Plasma was successful in nerve regeneration for patients with leprosy peripheral neuropathy – a situation where all traditional treatments have failed. Which means PRP injections are effective in restoring sensations when it has been lost. This is remarkable news.

Then there is another study conducted in Greece the shows very encouraging mid-term results regarding PRP for treatment of Carpal tunnel syndrome.

All of this is proof that Neuropathic pain can be alleviated by Platelet-Rich Plasma. This paper by a researcher at the University of Puerto Rico analyses how Platelet-Rich Plasma has been able to eliminate neuropathic pain. He reports that PRP’s ability to promote axon regeneration is the key.

Here’s a video from a Rejuv Medical where a patient explains how she had PRP Injections for Nerve treatments and how it changed her life remarkably.

3. Chronic back pain

Chronic back pain and sciatica are mysterious conditions and physicians generally have a hard time figuring out what’s causing them. They first thing they do is to scan the lower back area for defects. When they find one, they’ll recommend surgery to correct that defect even though they have no idea if that defect is indeed the culprit of the pain. When they can’t find any defects, they end up being puzzled and sent the patient away with a bunch of Advils.

In a spine health forum, a patient explains his situation which was similar. His physician suspected the tears in L4-L5 spine segment to be the causing the pain. But there were minor tears and bulges everywhere, so the physician was confused. The patient ended up having to take 8 Advils a day. Unable to continue with that, the patient skeptically tried Platelet-Rich Plasma injections. He went from not being able to sit back in office or drive in a car (even with those medications) to stopping the medications altogether and going on a family trip overseas. Talk about a dramatic shift in life experience!

Another patient on the same forum describes how she had PRP injection for chronic pain in the cervical spine, and it’s been pain-free for two years.

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These kind of stories are supplemented by occasional clinical studies like this where the patients not only had experienced near complete pain relief but also were able to sustain those results for 2 years. This is remarkable for a degenerative disease, aka, a condition that worsens as time goes by. Here are another study conducted in China and another one by Japanese researchers.

4. Joint Pain

In addition to back and knees, almost all other joints are being treated by Platelet-Rich Plasma now. As the science of PRP evolves, the treatment is vigorously gaining popularity with more and more patients demanding it from their physicians. After all, the procedure is incredibly straightforward and is easily understood by most. The physicians hardly need to talk before the patient accepts eagerly.

Hence the doctors are now quick to prescribe Platelet-Rich Plasma for any case of chronic bursitis – in areas like fingers, elbow, toes, hip, shoulders, neck, wrist, ankle, and hip – and the results are almost always positive.

In fact, Platelet-Rich Plasma can be – and must be – prescribed for more than 50% of the musculoskeletal issues that are usually treated with surgery or steroid injections.

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5. Post surgical pain

Surgical pain relief is one of the newer areas where Platelet-Rich Plasma is gaining ground. This is primarily to take advantage of the wound-healing and bone regeneration aspects of PRP, but pain-relief is a very evident beneficial side-effect. Some medical perfusionists advice Platelet-Rich Plasma after almost all surgeries including Neurosurgery, Tumor removal surgery, Oral and Maxillofacial Surgery, Head and Neck Surgeries, Reconstructions and Cosmetic Surgery, Orthopedic/Spinal Surgery, Hand and Foot Surgery, Bone Graft Surgery, Cardiothoracic Surgery and Bariatric Surgery.

By cutting short the time it takes to heal from the wounds of surgery, Platelet-Rich Plasma plays a pivotal role in assisting patients get productive as early as possible. And when done in conjunction with surgery, Platelet-Rich Plasma injections are almost always paid for by the insurance provider covering the surgery.

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The beginning of the end of orthopedic surgery?

At a time when big hospitals are racing towards a possible automation of orthopedic surgeries, there are some physicians who believe that the rise of Platelet-Rich Plasma together with the rise of stem cell technology marks the beginning of the end for 80% of the orthopedic surgeries. They say science is finally waking up to the fact that human intervention is not the most efficient way of dealing with musculoskeletal issues. Rather, it’s best to provide the necessarily biologics in the form of PRP and stem cells so that the body can invoke it’s own healing.

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I hope you agree – because today’s regenerative medical trends are certainly pushing the medical industry in that direction.

If you haven’t started offering Platelet-Rich Plasma – or would like to know some general protocols, we would love to share them with you. Just call us at (844) 377-7787 or email via hello@drprpusa.com.

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Foot And Ankle Surgeon’s Guide To Platelet-Rich Plasma

Some believe that Platelet-Rich Plasma is nothing but a new-age medical nonsense that preys on the gullible. And let me the first to admit that there are some carefully controlled studies out there showing that PRP Injections work no better than a placebo. But there are also thousands of doctors who swear by the efficacy of Platelet-Rich Plasma which seems to do a better job at healing patients, and at a much lower cost, than traditional medicine.

This trend is only growing.

What does these doctors see that escapes medical establishments’ eyes?

One branch of medicine where it is particularly evident is Podiatry. We believe that Platelet-Rich Plasma is not as widely accepted in Podiatry as it should have. Making it the first line treatment for pain in the foot and ankle treatments will help orthopedic surgeons to reduce complication rates, achieve favorable clinical outcomes faster, and improve patient satisfaction.

Here are some of the cases where a Foot and Ankle Surgeon might use PRP or PRFM (Platelet-Rich Fibrin Matrix).

1. Plantar fasciitis/fasciosis

It’s widely accepted that Platelet-Rich Plasma Injection has become a very common treatment for Plantar Fasciitis. Studies like this prove it’s efficacy. In the words of Dr. Daniel Kassicieh, D.O., FAAN, FACN, of Sarasota Neurology, PRP seems to be “one of the most effective treatments for Plantar fasciitis to actually cure it permanently.” He says many of his patients have avoided surgery with a single Platelet-Rich Plasma injection – no rehab, no down time, and certainly no unwanted consequences of surgery to deal with. That explains why Plantar Fasciitis has been the 5th popular musculoskeletal condition (the first four are knee meniscus, shoulder, shoulder rotator cuff and tennis elbow in that order) treated by Platelet-Rich Plasma. Part of the reason is that over 3 million people are diagnosed with this condition and we haven’t found a viable treatment for it yet.

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Here’s a video of the procedure done by Los Angeles Foot and Ankle Specialist Dr. Baravarian.

2. Achilles tendonitis/tendinosis

Achilles tendinopathy is a another difficult to treat condition which is progressive and often results in tendon rupture. Surgical approaches, either tendon debridement or tendon transfer, are risky and does not end up with predictable results. Patients are usually given corticosteroid injections to reduce pain. But studies like this have shown that Platelet-Rich Plasma is a much more helpful treatment than corticosteroids. Another study released by European Foot and Ankle Society revealed that a single PRP injection can be a safe and attractive alternative for the treatment of non-insertional CRATs than anything else available today.

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3. Diabetic Foot Ulcers

Non-healing diabetic foot ulcers are a major problem for diabetics and in the US, there are over 2.5 million people affected. Eleven percent of them may go on to have lower extremity amputation. That’s not pretty. But according to this study, just a single injection and a bi-weekly topical application of Platelet-Rich Plasma turned around the chronic non-healing ulcers of 24 patients in just 8.2 weeks. In another study, the effects of topical application of Platelet-Rich Plasma was compared with Anti-septic creams for clean diabetic foot ulcers and PRP was proved to be more effective.

Platelet-Rich Fibrin Matrix, derived from Platelet-Rich Plasma, is also another excellent candidate (as demonstrated in this study) for diabetic foot ulcer.

4. Bone regeneration

Foot and ankle is one of the most common areas where bone regeneration is needed. Though nothing trumps mechanical stabilization, researchers are now surprised by the role of Platelet-Rich Plasma.

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PRP assists bone and soft-tissue healing by providing platelets and thus growth factors at the site of damage. The phenomenon was studied recently, where they conducted a systematic review of all the 64 independent articles that discussed PRP’s role in bone tissue regeneration. This study calls for further optimization of the PRP treatment.

Nevertheless, the science for using Platelet-Rich Plasma for bone regeneration is solid. In order for bone or tissue to form, three key components are required at the surgical site. These three components are:

  • A scaffold for cellular growth and attachment
  • Biological stimulants that provide signaling proteins to recruit cells
  • Undifferentiated stem cells that provide osteogenic potential

The combination and synergy of these three key components is critical to bone formation. Platelet-Rich Plasma can provide two of three of these components — a scaffold and a biological stimulant. Hence there is no reason why we should not use it for assisting bone regeneration.

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5. Ankle Sprains

This is a fairly common condition among both professional athletes and weekend warriors. An ankle sprain can be a stretch, tear or a complete rupture of the ligaments in the ankle. In any of these cases, Platelet-Rich Plasma can be very effective in accelerating the healing process. In one of the randomized controlled studies, researchers analyzed the effect of Ultrasound-guided Platelet-Rich Plasma injections on athletes with Syndesmotic or high-ankle sprains. Platelet-rich plasma was injected into the injured antero-inferior tibio-fibular ligaments (AITFL) and their Return to Play (RTP) time was measured. Not only was the Platelet-Rich Plasma group saved 20 days of healing time, they also experienced significantly less residual pain. Expert physicians tell us that Platelet-Rich Plasma can cut down the normal 6-week recovery period for a torn ligament from an ankle sprain to just 2-3 weeks. That’s a 50% reduction in healing time.

Immobilization The Key In Successful Platelet-Rich Plasma Treatments?

One of the missing pieces when it comes to Foot and Ankle related injuries, is Rest and Rehabilitation. With or without Platelet-Rich Plasma, there is no avoidance of Rehab. And we found that some of the studies that disprove Platelet-Rich Plasma for Foot and Ankle Injuries were done without Rest and Rehabilitation – meaning they were testing whether Platelet-Rich Plasma is a stand-alone “magic pill.”

We can assure you that Platelet-Rich Plasma is not a magic pill. And that there is no avoidance of Rest and Rehabilitation. The Platelet-Rich Plasma injection must be followed by a standardized rehabilitation protocol – which, depending on the severity, can include full weight-bearing in a splint, pneumatic boot, or cast for a 2-3 weeks.

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What’s Feeding The Resistance For PRP Adoption?

We believe the biggest hindrance is the current system of healthcare. The big-pharma-dominated healthcare in the US would be more than happy to spend almost $2 trillion for chronic diseases than educate doctors on the advantages of alternative, autologous and integrative interventions such as Platelet-Rich Plasma. Studies after studies have shown that the earlier you introduce Platelet-Rich Plasma, the more results the patients end up getting. Yet, we’re in a system that encourages all kinds of short-term-results-oriented treatments before considering Platelet-Rich Plasma because it’s “expensive” and not reimbursed by insurance companies.

How Foot And Ankle Surgeons Can Benefit

The use of PRP in the foot and ankle is here to stay. So get involved with Platelet-Rich Plasma as soon as possible. Try it out with your patients. Play with the Platelet-Rich Fibrin Matrix. And before prescribing conventional drugs and surgeries, give your patients an opportunity to try Platelet-Rich Plasma at a low cost. We know how thankful your patients are going to be.

For more info on various protocols for PRP Injections, reach out to us at (844) 377-7787.

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