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Top Six Reasons Why Platelet-Rich Plasma Injections Fail

The other day we received an email from a person who had Platelet-Rich Plasma (PRP) Injection that failed to produce any results. “Not impressed, did not work for me. Had it done for my back,” she said. Comments like these are charged with emotions as almost all of these patients have paid for PRP injections out of their own pockets. That’s why the same patient also added later “…but did empty my wallet.” For us, her comment was one of the kinder ones. Others, who were really mad at seeing their money wasted, called it a sham, quackery, and “ways for doctors to make money.” We understand this sentiment. And we can’t argue with the fact that these treatments may have been failures.

But the thing is very few people, including some expert physicians understand why these PRP injections fail.

What The Tremendous Popularity Of PRP Means

In the 1990s, there were about 150 new research articles on Platelet-Rich Plasma every year. At least in the Pubmed database. Back then, only a select group of physicians who really understood the treatment actually offered it to their patients. Now, just this year alone, there were more than 600 new articles. The trend line has gone from a gradual climb to a “U curve” or exploding popularity.

Platelet-Rich Plasma PRP Injections Search Results Pubmed Database

And so did the number of physicians offering this treatment.

Certainly, money wasn’t the objective for those physicians – for if it were, the best ways to do it would’ve been to prescribe a battery of tests, drugs and surgeries approved by insurance companies. Instead, the physicians started offering it once they knew well the inherent benefits of an interventional autologous medicine like Platelet-Rich Plasma.

The problem is, not all physicians were that passionate about it.

Some did it because patients asked for it. Some did it because everyone else was doing it. Still others just wanted to experiment with it casually.

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And so not all Platelet-Rich Plasma injections worked. That’s why, as the treatment exploded in popularity, we saw a small portion of those treatments end up being a waste of the patient’s money – and that gets talked about a lot because, as I mentioned above, the patient usually has huge emotional response to the outcome.

But on the other hand, majority of the patients are happy about their results.

“I had it done on my injury and MAN, IT REALLY WORKS!!!”

That’s another response we got on the SAME DAY that this women told us it didn’t work for her. Another physician also told us the very same day, “PRP works great. We have had fantastic results on patients in the office.”

So what’s making the difference?

Why do some PRP treatments work spectacularly while some others turn out to be a dud?

That’s what we’ll explain in the rest of this post here. There are six main reasons why it can fail. Plus a seventh no-so-common reason. Let’s look at them one by one.

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1. Improper Selection of Patients

As much as the Platelet-Rich Plasma injection enthusiasts would like beat the drum of its universality of application, there are certain instances where a PRP injection may be unnecessary. The classic case is demonstrated in the 2015 Double-Blind Randomized, Placebo-controlled Study that showed that PRP injections are NOT beneficial at all.

According to expert researchers we subscribe to, it is clear that this study had selected the WRONG PATIENTS!!!

Here’s what that means. This study, conducted by researchers at Cooper Medical School of Rowan University, New Jersey, was done in the emergency care department where patients who’d just had a ankle sprain were given a Platelet-Rich Plasma Injection.

First of all, ankle sprains are relatively acute medical condition, commonly occurring due to over-stretching and tearing of the muscle or tendon. And they’re usually healed on their own. The thing that emergency care physicians usually do for this condition is to put ice packs or local anesthetic to numb the pain so the patient can rest. For patients who’re very active, their body is able to heal itself from most of these types of ankle sprains very rapidly. For them, a PRP injection might not accelerate healing. On the other hand, because injections break up the tissue and poke holes, it can actually cause unnecessary complications.

That’s why successful studies on Platelet-Rich Plasma Injections are almost always done on chronic wounds and injuries that wouldn’t heal on its own. If you’re out to test PRP’s efficacy, the untreated-by-PRP “control group” should be non-healable so we can determine clearly the effects of PRP.

So definitely, Platelet-Rich Plasma injections are not ideal for emergency care.

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The same is true for patients on the other end of the spectrum. That is the category of patients who’d been on steroids and drugs for a long time and are in the very advanced stages of the disease. Although there might be hope, Platelet-Rich Plasma might not be enough to reverse course here.

The ideal candidate for Platelet-Rich Plasma injection is a patient who has a relatively new, chronic musculoskeletal condition and whose only other option is surgery or heavy steroid/drug use.

2. Use of certain drugs

One of the other reasons why Platelet-Rich Plasma may not be ideal for emergency care patients is that when patients come in with intense pain, it’s a common practice for the ER physician to administer powerful local anesthetics and/or steroids in high dose. The problem with both of them is that they are are known to be toxic to stem cells and growth factors as shown here here, here and here. So if you’re using these steroids, anesthetics or drugs, it is recommended to wait till the patient can get off of them before applying Platelet-Rich Plasma. Otherwise, the toxicity of the chemicals may limit Platelet-Rich Plasma’s ability to recruit stem cells to the area.

For example, the local anesthetic Marcaine is found to be extremely harmful to stem cells even in small quantities. So as a general practice, the patient has to avoid harmful steroids, anesthetics and drugs at the time or up to 48 hours prior to PRP injections.

3. Lack of Rehab

It’s been reported that PRP injection works well when combined with the physical therapy for sports injuries. However, some physicians mistakenly see PRP injections as an alternative to physical therapy. Hence the comparisons like these where PRP is pitted as a rival to physical therapy. The fact is Platelet-Rich Plasma can only supplement the effects of a proper rehabilitation program as illustrated in this study which demonstrated that PRP + physiotherapy is more effective than Dry Needling + Physiotherapy for patellar tendonisis.

There is one thing we need to add to that though. Most PRP injections are done in a way that breaks up scar tissue and triggers new healing response to which the platelets can respond. So the best post-Platelet-Rich Plasma treatment rehab program is one which treats the patients as if they just had an acute injury. Meaning, the physiotherapy regimen following a PRP injection has to aim at square one – stimulation of blood flow to the injured area to provoke the inflammatory response. This is a different approach than the usual where the PT tries to attenuate the inflammatory response.

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4. Under dosing

Under-dosing is a serious problem in this field. If you’re using PRP with below 3X platelet concentration, you’re under-dosing your patients. An example is the PT vs PRP study we highlighted earlier. Not only did they mistakenly conclude that Platelet-Rich Plasma could be an alternative to Physiotherapy, they were severely under dosing the patients by using PRP with 2.1-2.5X concentration of platelets.

Studies have shown that a concentration of at least 1,000,000 platelets/µl is needed for optimal therapeutic benefits. That is 5X the concentration of platelets in normal whole blood. Here is one such study.

That is the very reason why we advocate not using Gel-based PRP Kit for PRP separation. The problem with gel-based kit is that most of the platelets will get trapped in the gel. Instead a kit like DrPRP kit gives you 5X-9X platelets because it uses a mechanical separation process while giving the same 1-step convenience of gel separators.

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5. Using PRP as just another injectate

There is a fundamental difference between Platelet-Rich Plasma based orthopedic intervention and typical modern surgical and drug-based treatment. And that is surgery and the drugs are designed to eliminate symptoms of diseases. For example, pain is one of many symptoms that occur when a certain part of the body is out of balance. By taking a drug, steroid, NSAID or even undergoing surgical correction, the physician hopes that the pain goes away. This approach has led to all the problems that we face in modern orthopedic medicine. Because when we treat symptoms, the underlying problems usually don’t go away.

But scores of physicians look at Platelet-Rich Plasma with that same attitude. They inject Platelet-Rich Plasma expecting the symptoms to go away.

That’s NOT what Platelet-Rich Plasma is for.

Platelet-Rich Plasma is a HEALING AGENT. It’s different. It’s not designed to eliminate symptoms like a drug. The only thing that PRP can do is use the body to heal itself.

So the first task, if you’re an orthopedic surgeon or someone treating a musculoskeletal issue, is to IDENTIFY precisely what’s producing the symptoms. This means looking at the connection between various muscles, tendons and ligaments. Understanding how they work in unison and finding out what’s causing stress in the system. All the muscles and ligaments and tendons are like different pieces of the puzzle – pulling weights in sync with their functions. So if there’s a anomaly in the whole picture, chances are one of the pieces of the puzzle is not able to carry out its job.

For an easy example, a tightness in the hamstring might be a result of a twisted ligament or bone in the back caused by a bad sitting posture. So in addition to injecting PRP to the hamstring, you might also need to inject to the ligament or bone on the back. And advise the patient to change posture.

This is the definition of Interventional Orthopedics.

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And it requires extensive experience on the anatomy – AND delivering precise injections into the weaker links in the musculoskeletal system to improve overall function of the body. This means using image guidance technologies like fluoroscopy (Ultrasound guidance isn’t enough) to accurately place Platelet-Rich Plasma on areas which require healing. These type of injections enable efficient tissue regeneration and healing, and is usually not taught in medical school, residency, or fellowship.

That’s why we encourage physicians who’re offering PRP injections to get certified by taking one of the courses at the non-profit Interventional Orthopedics foundation.

Getting certified in Advanced Injection practices will make your Platelet-Rich Plasma results more consistent. There is a must-have for all physicians offering PRP Injections. It will also educate you on all the different ways regenerative medicine is being used right now.

6. Thinking only about relieving pain

We touched on it a little on the section above, but this is a broad topic that deserves an explanation on its own. Platelet-Rich Plasma as a healing tool is not something that you should make use of when your patients are in pain. Instead, PRP is used for a wide variety of issues that doesn’t involve pain including wound healing, skin aging reversal, wrinkle correction, dry eye syndrome, nerve regeneration, bone union, hair regeneration and even women’s fertility restoration and strengthening the uterus.

The bottom line is… Platelet-Rich Plasma isn’t just a tool for containing pain due to sports injuries. That days are far behind us now. Today, every physician, from the family physicians to neurologists and cardiologists, to fertility specialists and optometrists, to dermatologists and hair restoration experts… everyone uses Platelet-Rich Plasma.

Plus, more and more applications are discovered every day.

Platelet-Rich Plasma, on its own without funding by Big Pharma or the government, has become an integral part of modern medicine.

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BONUS: The 7th Reason Why PRP Injections Fail

7. Super-concentration of Platelets

We know all analogies are imperfect but we like to use the expresso shot analogy when it comes to platelets. Platelets are like expresso shots for healing. But like expresso shots, your body can’t function using expresso shots alone. It needs food. That’s why studies like this one by Giusti has shown that super concentrating the Platelets may not only be useless, it can actually be harmful. What they did was completely isolate Platelets and platelets alone – and applied it in different concentrations on tendon cells to see if higher concentrations hurt or helped. That’s not Platelet-Rich Plasma. That’s just platelets.

And Platelets alone can’t do the job. In fact, it has nothing to support the survival of cells.

Instead, Platelet-Rich Plasma, is rich in Platelets while also including a small portion of RBC, WBC and the plasma serum which contains the nutrients the cells needed to survive.

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That’s why research shows that taking the concentration above 1,000,000 platelets/µl doesn’t necessarily increase therapeutic benefits and as the Giusti study pointed out, it can actually have a detrimental effect.

This may not be an issue for the average physician, but it is possible to make this mistake thinking that higher concentration is better. That’s why we believe choosing the right Platelet-Rich Plasma kit plays an important role.

Because the kit has to produce Platelet-Rich Plasma in the ideal concentration – not just Platelets – so it can work every single time you administer it on patients.

Patent Application By Allan K Mishra

Speaking of the composition of Platelet-Rich Plasma, the famed Stanford researcher and Platelet-Rich Plasma pioneer Allan K. Mishra has recently filed a patent application titled “PLATELET RICH PLASMA FORMULATIONS” which can be found here. In it, Mishra claims he’s identified specific concentration of platelets, red blood cells, and white blood cells for treating treating connective tissue and/or cardiac tissue damage. It’s worth a look if you’re curious.

Add Regenerative Medicine to Your Practice

If you need help in getting started with Platelet-Rich Plasma, don’t hesitate to give us a call at (844) 377-7787 for a quick consultation. We can support you not only in supplying all the necessary equipment, but also provide you with the information you need to be a confident pioneer in this field. We’re looking forward to having you as part of our family.

You can also email us via hello@drprpusa.com or visit our shop to order directly.

Thank you for reading our blog. We love you.:)

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How Platelet-Rich Plasma Is Changing Arthritis Treatments

From a mere 6% in 1940, the rate of knee arthritis in our nation has jumped to almost 16% to become one of the top causes of disability. The consequences are paramount as arthritis doesn’t just affect knees – it overpowers people with fatigue, pain, depression and even difficulty getting out of bed. Over the past few years, Platelet-Rich Plasma has quietly emerged as a
savior for many of these patients. It ushered in the anabolic era of treating Arthritis.

Of course, this coincides with Platelet-Rich Plasma’s skyrocketing adoption rate and it’s media popularity. In fact, it has become so popular that, there is even a research paper about it’s popularity!

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How Platelet-Rich Plasma Is Changing Arthritis Treatments

Traditionally, the only road available for chronic knee arthritis patients was the road to total knee replacement. It will start out with the administration of corticosteroid injections. After going through that for quite a bit, the patient will show no further progress and the surgeon would suggest knee arthroscopy for debridement of affected tissues. That would feel better for a while before the patient returns for more. The surgeon would then give them a date for total knee replacement.

All of that has changed with Platelet-Rich Plasma and Stem cell treatments. Now, we have found out that the best bet we have is to administer Platelet-Rich Plasma at the earliest stages of knee arthritis to regenerate the affected tissues as soon as possible. Platelet-Rich Plasma, with its growth factors and cytokines, not only relieves the symptoms but it is proven to reverse the condition as time goes by. It creates a very beneficial, positive cellular change in the joint pathology.

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All of that without the adverse effects of an invasive surgery.

Proven Regeneration Tool Abandoned By The Big Pharma

Right now, Platelet-Rich Plasma is used for a number of musculoskeletal conditions like Rotator cuff injuries, Tennis and golfer’s elbow, Ligament strains, Knee instability, Chronic back pain, Knee and Achilles tendonitis and more. There is no adverse effects or long term implications. Few other treatments can match this record. The important distinction to be made when comparing Platelet-Rich Plasma with other existing treatments is its regeneration potential. Injecting PRP doesn’t just correct the condition – it has the potential to make it a little better than before. As far as research is concerned, most of the PRP literature concerns around knee osteoarthritis. Here’s a Level 4 systematic review and a more recent Level 1 systematic review of 10 studies with a total of 1069 patients if you want to verify the results.

Of course, it doesn’t mean all you need is a couple of PRP Injections and things will be better. Or maybe that’s it?

If the big pharma is able to package this and market, they would’ve carved out a multi-billion dollar market by now. But they can’t because the primary raw material – blood – has to be autologous and fresh for this to work efficiently. Some researchers are exploring the possibility of freeze-drying Platelet-Rich Plasma. This may or may not work depending on how well it can preserve the key elements of Platelet-Rich Plasma – the bioactive proteins in the platelets, plasma and white blood cells.

According to Bert Mandelbaum, MD, DHL (Hon), Chairman of Santa Monica Orthopaedic & Sports Medicine Foundation and Co-Chair of Medical Affairs at the Institute of Sports Sciences, Cedars-Sinai, Platelet-Rich Plasma is more promising than stem cells. See his recent article in Medscape here.

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Still there are plenty of doctors who comes to us asking, “Where is the research? The FDA-cleared prospective, multi-center, sham-controlled, randomized, double-blind clinical trials?” Actually, the FDA is hard at work clearing devices that provide relief of pain and symptoms associated with knee osteoarthritis (OA) for up to 90 days by nitro-freezing the nerves!

Many Research, Many Doctors

The amount of research from independent research institutes around the world on Platelet-Rich Plasma is just a tad bit overwhelming. New findings are published almost every month on the topic. The vast number of research mirrors the immense potential of PRP Injections. And for knee osteoarthritis, there is already unquestionable proof.

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Here are some of the advocates of Platelet-Rich Plasma:

  1. Caring Medical’s Ross Hauser, MD has written a well-researched article about Platelet-Rich Plasma for knee osteoarthritis here.
  2. Dr. Lewis G. Maharam, MD, FACSM, one of the world’s most extensively credentialed and well-known sports health experts known as Running Doc™, always show great enthusiasm when describing Platelet-Rich Plasma.
  3. Best selling author and team physician of Philadelphia 76ers, Dr. Nicholas DiNubile MD recently wrote an article saying Platelet-Rich Plasma may make knee-replacement surgeries a thing of the past.
  4. Famous Long Island physician Dr. David J. Weissberg, MD, says for his patients, with just one shot of PRP, in general, gets relief from their problems without any need for surgery and slow but progressive cure in their problems.
  5. Dr.Kevin F. Darr, M.D., a national leader in orthopedic medicine and a visionary in cell therapy, combines PRP with other cell therapies and finds the results “outstanding.” Dr. Darr is one of the fifteen physicians selected to participate
    in an FDA approved Level 1 clinical study utilizing cell therapy techniques. Here’s a recent testimonial from one of his patients.

Of course, there are many more. But for those who’re skeptical in trying Platelet-Rich Plasma or even offering them to their patients – a doctor once told me he’s skeptical because he might appear as a greedy physician to his patient if he offered unproven techniques for the sake of trying it – they can rest assured that many nationally reputed doctors are ardent fans of this therapy. Plus, there’s really no risk in trying it.

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The Best Approach For Skeptical Doctors

We know many of your patients rely on medical insurance coverage for their osteoarthritis and other treatments. And many of them are pensioners. Asking them to pay out of their pockets for a treatment that you yourself have doubts in – that’s impossible. While we hope the insurance starts accepting it, we can’t just ignore the results. You’ve seen the research, and heard the testimonials and read the media pieces.

So instead of wondering whether it might work – why not give your patients a try. Give the first treatment for FREE. Yes, I’m suggesting you let your patients try it out for FREE.

From what we’ve seen so far, once patients clearly experience the healing results – they’ll come back for more and you’ll more than make up for the FREE treatment you provided them.

We’ve seen over and over again – in several clinics – that patients always come back for more.

Like this case from Dr. Payel Banik’s office. (Dr. Payel is the owner of Osteopathic Healing Hands, Houston, TX.) The patient in the video below explains why he’d come back for more.

Offer Your Patients A Free Platelet-Rich Plasma Injection

So what do think? Are you going to stand on the lines and watch until government regulatory boards mandate PRP for osteoarthritis and other conditions? Or are you going to start helping your patients right now? Start offering it for FREE so that YOU will be convinced that it works. And win over your patients in the process. And watch them come back for more.

The choice is yours.

If you’re seeing a lot of patients with intermediate to advanced stages of osteoarthritis or other similar musculoskeletal conditions, offer them a FREE Platelet-Rich Plasma injection starting today. We’re very confident that it will make the fall in love with this treatment for life! There will be plenty of referrals for you.

All you need is a PRP Kit and a compatible centrifuge and you’re good to go. Call us at (844) 377-7787 if you need more info.

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Dermatologists Guide To Platelet-Rich Plasma PRP Hair Regeneration Hairloss Treatment
The Dermatologist’s Guide To PRP Hair Regeneration

As a powerful medium of regeneration, Platelet-Rich Plasma has seen the most aggressive growth in demand among patients suffering from Alopecia. This is despite the relative lack of evidence surrounding the treatment. All because the results of PRP Hair Regeneration just can’t be ignored.

Dermatologists Guide To Platelet-Rich Plasma PRP Hair Regeneration Hairloss Treatment

And researchers are starting to take it more seriously now.

New studies are emerging that prove the results are more than just opinions of dermatologists. The most recent one is a study published by Egyptian researchers, where they analyzed the results of 90 patients for a period of 3 months using digital camera photography and dermoscopic scans, and concluded that Platelet-Rich Plasma is more effective in the treatment of Alopecia than widely accepted topical minoxidil 5% solution.

Dermatologists Guide To Platelet-Rich Plasma PRP Hair Regeneration Hairloss Treatment

Prior to that, in a literature review by University of Miami and Brown University researchers, they found that, among the 12 studies they looked at, 10 of them had positive results showing Platelet-Rich Plasma was beneficial in treating Alopecia.

The Holy Grail Of Hair Science?

One of the most interesting studies is a study conducted by researchers in Southern Medical University, China. Although the study was conducted on lab mice, it presented very conclusive evidence for Platelet-Rich Plasma as a powerful biologic substance that both shortened the time of hair formation and increased the number of newly formed follicles. The possibility that Platelet-Rich Plasma can promote both of these functions at the same time makes it the holy grail of hair science.

There’s also this other study By Italian researchers suggest that the optimal concentration of Platelet-Rich Plasma for PRP Hair Regeneration is 1.5 million platelets per microliter and that higher concentrations doesn’t seem to improve results (or may at times minimize the results). Although the study size is small (20 patients), it reported significant positive results after administering three PRP injections for each patient at 30-day intervals.

Little wonder that during the AAD 2017 Summer Meeting, it was one of the hottest topics discussed.

American Academy of Dermatology 2017 Summer Meeting

At the American Academy of Dermatology 2017 Summer Meeting, which took place a few days ago, Dr. Neil Sadick, MD, from Weill Cornell Medical College, was quoted as saying  that Platelet-Rich Plasma is the hottest therapeutic tool dermatologists nationwide are talking about. Dr. Sadick also acknowledged the lack of a standardized treatment protocol that is holding back the procedure from going mainstream. But all of this is about to change as he mentioned that there are three MAJOR ongoing studies on the topic of PRP Hair Regeneration currently, whose outcome may shift they way this treatment is perceived right now.

Dr. Sadick’s co-presenter, Dr. Maria Hordinsky, MD, said that there’s no question that the demand is growing. And advocated dermatologists to start accepting the reality that if they don’t believe in it now, their customers might go somewhere else to get it.

She concludes by saying, “You have to get on the bandwagon of PRP if you work with patients with hair loss. There is no choice. It is very popular.”

Lack Of Evidence Or Lack Of Funding?

The lack of clinical studies may allude to the fact that funding for this kind of research is next to impossible to obtain. The Brown University and University of Miami researchers who conducted the literature review we cited earlier did not receive any funding for their work.

And so are almost all other literature on PRP Hair Regeneration. It explains the relative lack of robust evidence. But the dermatologists on the field are amazed by growth in demand they’re seeing. PRP looks like a disruptor in the long-stagnant Hair Regeneration industry. What they thought was a passing fad is now turning out to be a powerful force.

Isn’t time that every dermatologist in the country embrace Platelet-Rich Plasma as a standard treatment? Read this article to learn about other reason why you should consider offering the Platelet-Rich Plasma suite of treatments.

Dermatologists Guide To Platelet-Rich Plasma PRP Hair Regeneration Hairloss Treatment

82% “Worth It” Rating In Real Self

Perhaps the best indicator of the effectiveness of a treatment is the customer feedback. The website Real Self is a portal that lists different cosmetic treatments and asks its user to share their experiences. PRP Hair Regeneration is among the most popular treatments discussed in that portal. And on this portal, PRP Hair Regeneration has a whopping 82% “WORTH IT” rating as rated by real customers who’ve had the treatment. It is also the cheapest treatment listed on the site with an average cost of just $1675.

One user in Real Self, who posted a before-after picture that was taken after only ONE PRP treatment, says he was impressed by how much Platelet-Rich Plasma had thickened his receding hairline. Comments like this are not uncommon on the Real Self portal.

More and more patients are seeking out PRP Hair Regeneration instead of the oral drugs and topical medicines because of its holistic, regenerative aspect. This is a “true solution” for hair loss with NO MAJOR SIDE EFFECTS.

Dr. Amiya Prasad, MD, a cosmetic surgeon and fellowship-trained Oculofacial plastic and reconstructive surgeon who’s been in practice for over 20 years, says, he has no doubt about the efficacy of PRP Hair Regeneration. In fact, he even says that he’s never seen any reversal of results in his patients.

Dermatologists Guide To Platelet-Rich Plasma PRP Hair Regeneration Hairloss Treatment

6 Lessons From More Than 1,000 PRP Hair Regeneration Treatments

Here are the tips shared by top dermatologists who’ve each performed more than 1,000 PRP Hair Regeneration treatments for their clients.

  • 1. There is no substitute for precise intra-dermal injection of Platelet-Rich Plasma at the level of the follicles.
  • 2. It may be helpful to be supported by micro-needling and topical Platelet-Rich Plasma in some cases.
  • 3. The concentration of platelets must be at least 5x the baseline or 1.5 million platelets per microliter (μL).
  • 4. Combining Platelet-Rich Plasma with non-surgical medication and laser light therapy may be beneficial.
  • 5. PRP Hair Regeneration is usually done 3 sessions about 1 month apart, followed by one more session about 12-18 months later depending on the results.
  • 6. Addition of an allograft matrix product to Platelet-Rich Plasma can greatly enhance the results of regeneration.
How to Prepare Platelet-Rich Plasma

Based on the input from dermatologists and Platelet-Rich Plasma experts, here’s how you can prepare the Platelet-Rich Plasma for hair regeneration.

There are three types of Platelet-Rich Plasma Kits. The ones that uses separator gels, ones that uses buffy coat with a single spin on the centrifuge and the ones that uses buffy coat with double spins on a centrifuge. Almost all physicians agree that the last option – using a buffy coat based Platelet-Rich Plasma kit that can be double spun produces the best concentration of 5X-7X above baseline, i.e., more than 1.5 million platelets per micro liter.

Dermatologists Guide To Platelet-Rich Plasma PRP Hair Regeneration Hairloss Treatment

This concentration packs the most nutrients for the regeneration of blood vessels and recruitment of new stem cells that are required for hair regeneration.

The way to achieve this concentration using the DrPRP Kit is simple.

  • 1. Draw 17cc of blood into a DrPRP tube pre-filled with 3cc Anti-coagulant ACD-A.
  • 2. Centrifuge it for 3400 rpm for 4 minutes.
  • 3. You’ll see perfect PRP separation (else you can centrifuge it for another 1 minute.)
  • 4. Sequester the platelet serum from the RBC by adjusting the knob at the bottom of the DrPRP tube.
  • 5. Centrifuge it for another 6 minutes at 3,200 rpm.
  • 6. You’ll get about 10cc of Platelet serum with Platelets lying at the bottom of the chamber. Draw out the top 6cc of the serum, which is the Platelet-Poor PRP.
  • 7. The remaining 4cc is your Platelet-Rich Plasma that has more than 1.5 million platelets per micro liter. Shake it well, draw it out in a syringe and administer it.
With Micro-needling Or Without?

Some dermatologists’ recommended PRP Hair Regeneration protocol includes Micro-needling with topical application of Platelet-Rich Plasma. In some cases of hair loss, this can have a beneficial effect.

Dermatologists Guide To Platelet-Rich Plasma PRP Hair Regeneration Hairloss Treatment

Micro-needling, using a device like Bella, creates a series of micro-trauma that warrants a healing response in a manner that covers the entire area of the scalp. This together with the applied Platelet-Rich Plasma will stimulate growth activities in the cells.

Most dermatologists who do micro-needling sandwich it between PRP injections. Say they’re giving a 3-session treatment at a 30-day interval, they’ll inject Platelet-Rich Plasma deep into the derma for the first and the last treatments while the second treatment will be just the Micro-needling with topical application of Platelet-Rich Plasma.

So yes, it is purely optional. With or without this, there is no avoidance of intra-dermal application of Platelet-Rich Plasma for PRP Hair Regeneration. Micro-needling with PRP is most effective for skin rejuvenation of wrinkles and sun damage.

If you’d need a micro-needling system, check out our Bella Micro-needling device. It’s been used by some of the top skincare centers we know.

Dermatologists Guide To Platelet-Rich Plasma PRP Hair Regeneration Hairloss Treatment

PRP with Allograft Matrix

One of the hidden gems we uncovered when looking at Hair Regeneration experts is that they often combine Platelet-Rich Plasma with some kind of allograft matrix. Allograft matrices are widely used in chronic wound healing – it actively changes inactive adult stem cells back into progenitor cells (its active form) and facilitates faster healing and regrowth.

When a high concentration of Platelet-Rich Plasma is combined with Allograft matrix, the matrix acts as scaffold for growth-factor induced cellular proliferation. There are many respected hair restoration experts in the field offering this combination with a very high degree of success. One prominent NY-based hair restoration expert says this combination has never failed to work in his practice with hundreds of clients.

The most commonly used Allograft matrix is derived from porcine urinary bladder tissue. But we recommend a more superior allograft matrix that is derived from amniotic fluid and tissues. This type of Allograft matrix is “immune privileged” meaning that it can be introduced into the body with virtually no chance of a harmful immune response as compared to allografts obtained from porcine bladders.

If you want to choose an allograft product, take a look at our post on the topic.

DrPRP USA Amnion Allograft Matrix For PRP Hair Regeneration

Standard drugs vs PRP Hair Regeneration

So far the widest prescribed drugs for male pattern hair loss are Minoxidil and Finasteride. These drugs are designed to prevent progression of hair loss. Minoxidil works by opening up the cell channels allowing more oxygen, blood, and nutrients to reach the follicles. Finasteride prevents the conversion of testosterone to dihydrotestosterone (DHT) which translates to less androgen activity in the scalp. In other words, these are temporary solutions. If these drugs are discontinued, any therapeutic benefits will reverse within about 6 months. I think almost every physician knows that. And the people who take these drugs will still lose hair as it’s not 100% effective in its function of stopping hair loss. Plus as I said, there’s no stimulatory effect on hairs.

You may know where I’m going with this. Platelet-Rich Plasma is a whole another story. It’s perhaps the only treatment out there that has clinically proven to regenerate hair follicles. Meaning it not only slows down hair loss, it actually helps promote new hair growth. The question is how long can the effects last. Some patients report that a single injection treatment with a combination of PRP and Allograft injection has produced for them hair regeneration results for FIVE YEARS AND RUNNING. Of course, different patients have varying outcomes.

The point is… until recently we only had two serious options for hair loss recovery. We had drugs that produced temporary effects, and we had surgery that transplanted hairs. And nothing in between. That’s why PRP Regeneration has gained a lot of traction recently.

This doesn’t mean all other treatments are obsolete. Some patients prefer a comprehensive approach to battling hair loss and they’ll want to fire-on-all-cylinders right from the start. Fortunately, Platelet-Rich Plasma treatments have little side effects or contra-indications and can be safely combined with other treatments.

Combining PRP with other treatments for maximum results

We haven’t found any adverse effects in using Platelet-Rich Plasma with either the Minoxidil foams or the Finasteride drugs, nor with other Laser light scalp stimulation therapies. So potentially you could do it all together. It’s entirely up to your patients – whether they want to focus on PRP Hair Regeneration alone or also pursue temporary solutions like drugs, foams and light therapy.

Another potential treatment that can be combined with Platelet-Rich Plasma and Allograft injections is Vitamin D. Vitamin D is proven to increase transformation of hair follicles.

Get On The Bandwagon Of Platelet-Rich Plasma

The trend for PRP Hair Regeneration, PRP Skin Rejuvenation, PRP Sexual Revival And PRP Facelift Procedures are on the rise. And it’s not showing signs of any slow down.

As many of the dermatologists already believe, you have to get on the bandwagon – there’s no choice. The demand for this treatment is only growing. And by refusing to believe in it, you’re potentially denying your customers their right to use regenerative medicine.

Dermatologists Guide To Platelet-Rich Plasma PRP Hair Regeneration Hairloss Treatment

If you’d like to talk to us about the specifics of various protocols, give us a ring at (844) 377-7787. Or head on to our shop to order a trial pack. We’ll be happy to assist you in making a decision about Platelet-Rich Plasma. And don’t worry, we’re not sales professionals. We’re medical professionals just like you. : )

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The Osteopathic Physician’s Guide to Platelet-Rich Plasma

Even though they’re licensed to perform surgeries, Osteopathic Physicians are primarily trained to keep their patient’s treatments as non-surgical as possible. Furthermore, their philosophy leans towards prevention and overall wellness than on treating diseases. And for these reasons, we believe Platelet-Rich Plasma is one of the best treatment options they have. After all, the Osteopathic profession was founded on the basis of the human body’s innate capacity to heal itself – the very function PRP injections perform.

The Journal of American Osteopathic Association reviewed Platelet-Rich Plasma a while ago and concluded that more studies are needed. Later another study was presented about a surprising case of an 18-year-old high school football player’s rapid healing of muscle injury through Platelet-Rich Plasma. So even though PRP injections are not officially heralded as the future, Osteopathic Physicians stand to gain much, much more than from Platelet-Rich Plasma than others.

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Platelet-Rich Plasma, An Osteopathic Physician’s Best Ally?

Here’s why we think PRP Injections is probably the best treatment to arrive in Osteopathic Physicians hand.

1. PRP is holistic.

Osteopathic Physicians love treating the whole patient, rather than just the disease. And so is Platelet-Rich Plasma, which merely utilizes the body’s own healing mechanism. And it’s not aimed at eliminating just one symptom either. It heals entire areas – this is evident in cases where multiple symptoms are eliminated after administering PRP. For example, there are many cases where female patients experienced sexual revival after being treated with PRP injections for urinary stress incontinence. So even though PRP Injections were pioneered by allopathic doctors – who still are some of its best advocates – Platelet-Rich Plasma basically functions like an Osteopathic medicine. That’s why we think it’s one of the best allies of an Osteopathic Physician.

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2. PRP is a musculoskeletal hero

Depending on the specialization of the Osteopathic Physician, chronic musculoskeletal pain can be one of major issues that they deal with. And we know PRP Injections are slowly becoming the first-line treatments for musculoskeletal issues. For example, some researchers believe PRP should be first-line treatment for Knee Meniscus issues. Last year (2016), Dr Patrick Smith from the University of Missouri, Columbia, published the results of an FDA-Sanctioned, Randomized, Double-blind, Placebo-controlled Clinical Trial on Platelet-Rich Plasma for Knee Osteoarthritis – and they concluded that PRP provided safe and quantifiable benefits. Here’s another systematic review summarizing about 29 of those studies.

3. Limitless potential of PRP is hard to ignore

There is a third reason why all physicians, let alone Osteopathic Physicians, must get acquainted with PRP Injections – and that is PRP’s vast scope of application. Because Platelet-Rich Plasma’s mechanism is generic (and straightforward), it can be safely assumed that if it works on knees, it can work on any joints, muscles, tendons, bones etc. It’s only a matter of time that PRP Injections will be a standard first-line treatment for all musculoskeletal issues. If you’re keen on hard evidence, have a look at these the randomized trials as well as other studies in the NCBI database.

This limitless potential is especially a boon for Osteopathic Physicians as they look at problems through their Unity of Function lens. Because if there is a strain for a patient on the wrist, there may be other areas of the FASCIA that might be linked to the trouble on the arm. In cases like these, multiple Platelet-Rich Plasma injections on different areas can significantly enhance the typical Osteopathic treatments for restoration of balance and freedom to the entire body.

Dr. Peter Lewis, a fellow of the American Academy of Regenerative Medicine, and the clinical director of the Surecell Group, who’s administered over 100,000 PRP injections to 12,000 patients says, “More than 80% of the patients who undergo PRP treatments enjoy very good results. Even people who’ve been told they’d need surgery have a 70% chance that Platelet-Rich Plasma will help them.”

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List of conditions treated by Platelet-Rich Plasma [INFOGRAPHIC]

For your reference, we’ve included a nice INFOGRAPHIC here that lists common PRP treatment areas.

(Click here to download high-resolution version)

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Are these treatments FDA-Approved?

At the time of writing, Platelet-Rich Plasma treatments are not subject to FDA approval. Because all of these treatments are performed on the same day with minimal manipulation of the patient’s blood. This feature places the PRP procedure within the FDA Code of Federal Regulation (CFR) title 21 Part 1270 1271.1 and as such it enjoys exemption. (FDA rule in 1271.15 (b)).

So no, you do not have to follow the traditional FDA regulatory pathway.

If you need more help, call us at (844) 377-7787. Or check out our Platelet-Rich Plasma store.

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How to choose the best PRP Kit (Platelet-Rich Plasma) 1
How to choose the best Platelet-Rich Plasma (PRP) Kit

For an incredibly straightforward process, the science of Platelet-Rich Plasma extraction has been surrounded by scores of debating researchers for over a decade about the composition and the method. Today, we’re going to clear up all of that by helping you choose the best Platelet-Rich Plasma (PRP) kit.

How to choose the best PRP Kit

First of all let’s talk about not using a kit. Yes, you can draw blood into a test tube, centrifuge it, take the top portion and call it PRP. That’s called “bloody PRP” and it is the least effective containing maybe 1-1.5x platelets if you’re lucky – and a whole lot of Red and White Blood Cells. This is what you should not ever think of doing because it’s not the real Platelet-Rich Plasma. In some cases, this way “bloody prp” has been known to have caused post-injection flare ups.

Using a Platelet-Rich Plasma kit on the other hand, you can get a platelet concentration anywhere between 5X and 7X the average.

How to choose the best Platelet-Rich Plasma Kit

This 5X-7X concentrated serum is what is known as Platelet-Rich Plasma or Autologous Conditioned Plasma. These professional kits allow you choose to allow or disallow red and white blood cells in your final product depending on applications. For example, researchers now suggest Leukocyte-poor Platelet-Rich Plasma for osteoarthritis and Leukocyte-rich Platelet-Rich Plasma for tendinopathy applications.

However, there are some commercial kits that may not deliver exactly what you want in your PRP.

To understand that fully, here’s a diagram of the components in blood.

How to choose the best Platelet-Rich Plasma Kit

And here’s how it will segregate itself after centrifugation.

How to choose the best Platelet-Rich Plasma Kit

Based on the technique of segregation, the kits are classified into two types.

1. Gel separators

Gel separators are those that basically nothing but a special test tube with some gel inside. It works because the gel has the density that’s in between blood and platelets. So when you fill it with whole blood and spin, the platelet portion of the blood will go to one side of the gel and the blood portion on the other side. But the biggest drawback of these gel-based PRP kits is that most of the platelets will end up getting caught in the separator gel itself. Hence the 1-1.5X concentration you get when you sequester the platelet part. One positive aspect is that the gel also separates white blood cells. So the PRP obtained is has almost zero RBC and WBC.

2. Buffy coat based

The kits that produce a visible buffy coat layer after centrifugation are the best at giving concentrations of platelets anywhere from 5X to 7X. What’s a buffy coat? Buffy coat is a thin layer, neutral or buff in color, formed between the blood and the platelet serum and are essentially plasma with suspended platelets. Now, having a buffy coat by itself will not be of much use. Instead you must be able to carefully separate the buffy coat from the RBC without contamination. When separated the right way, the buffy coat will be mostly plasma and white blood cells (leukocytes) with 5X-7X platelets concentration with less than 10% RBC.

How to choose the best Platelet-Rich Plasma Kit

3. Buffy coat based, double-spin

Yes, there is a third type of Platelet-Rich Plasma kits and those are buffy-coat based and that can do double-spin without introducing further Red Blood Cells into the mix. This is the best Platelet-Rich Plasma kit you can hope to have. Because essentially what it can help you do is sequester the Plasma + Platelets mix and do a further short run spin in the centrifuge to further isolate the Platelets. This time the platelets will be accumulated at the bottom of the Plasma serum. Once this is done, all you have to do is take the bottommost portion of the serum which will be 5X to 7X concentration of Plasma. This is what is called Platelet-Rich Plasma or Autologous Conditioned Plasma.

Getting this kind of end-product is key here as researchers have identified that for clinical benefits, the Platelet-Rich Plasma needs to be 1 million platelets per μL or more. This is 5x to 7x the normal platelet count of 200,000 platelets per μL.

How to choose the best Platelet-Rich Plasma Kit

The DrPRP Kit – Probably The Best PRP Kit

There are various kits for Platelet-Rich Plasma separation. But our kit, the DrPRP kit, is special in that it uses the dynamics of the tube design to give you full control over the end-product. You can get 10cc of usable product that you can manipulate to your specific needs. You can sequester the platelet serum and double spin it for 5X-7X above baseline platelet concentration. You can get a completely amber product or red product depending on whether you want a little red blood cells in your end product or not.

Leukocyte-Poor Platelet-Rich Plasma

When you’ve gotten the Platelet-Rich Plasma, deciding on if you need Leukocyte-poor Platelet-Rich Plasma is the next step. Although there is no consensus on the presence of leukocytes, some researchers maintain that the leukocytes are inflammatory and may inhibit the power of cytokines and growth factors to create new cells. The researchers on the other side of the argument claim that without inhibitory effect of the leukocytes there will be excessive scar tissue at the healing site. Leukocytes-Rich Platelet-Rich Plasma is known to contain more growth factors like TGF (which improves collagen synthesis), PDGF (increases cell metabolism) and VEGF (assists the formation of new blood vessels).

Other studies show that Leukocyte-rich PRP is most effective in the treatment of tendinopathy while Leukocyte-poor PRP is most effective in the treatment of osteoarthritis. It’s better that you try them out both and come to your own conclusion.

In case you need to use Leukocyte-poor Platelet-Rich Plasma, you may need a Leukocyte-Reduction (LR) filter. Conventional LR filters use electrostatic attraction in micro-sized filter membrane to retain Leukocytes while allowing the rest of the components to pass through. Drawbacks of this filter include clogging of the filter membrane half-way through the filtering process. A better LR filter is based on Controlled Incremental Filtration (CIF) method. With the CIF-LR filter, you will be able to remove 99.99% of leukocytes from the Platelet-Rich Plasma.

How to choose the best Platelet-Rich Plasma Kit

The Lack Of Clinical Evidence Myth

Let’s address ignore the elephant in the room, shall we? There are some doctors who believe that Platelet-Rich Plasma is just a fad. They say, “Show me the double-blinded peer-reviewed evidence.” It’s not that the other stuff they use for their patients are all double-blind proven and peer-approved. They just want to see it for this one. It doesn’t matter that the scientists who discovered growth factors in plasma got Nobel Prize in the 1950s. It doesn’t matter that they started using Platelet-Rich Plasma to heal gums in 1970s. It doesn’t matter than there are more than 6,000 studies on it till now. Use this search query in the NIH database and you’ll spot more than 1000 of them.

The hard evidence is of course money. Why are hundreds of thousands of customers taking out hundreds of dollars out of their wallets to pay for Platelet-Rich Plasma? Why are the independent researchers worldwide spending the very little research dollars they have (compared to the big pharma research moola) on studying this treatment?

A doctor who’s reviewed over 700 PRP treatments said the treatment has over 70% satisfaction rates with over 50% patients coming back for more.

How to choose the best Platelet-Rich Plasma Kit

An Incredible Healing Story

So far, Platelet-Rich Plasma is spreading mainly through word of mouth. Many patients take it up as the treatment of last-resort and later go on to shout it over the mountains. Here is one such story.

Three years ago, Bernie (not real name) came to see an Orthopedic Surgeon for a troubled shoulder affected by OA. After trying out the usual remedies, the OS suggested a shoulder replacement surgery. He wasn’t willing to do it. But the pain became unbearable. So the OS got him to do an arthroscopy instead. Bernie came out of the “clean out” like a new person. Unfortunately, the feeling didn’t last long.

In fact, things started getting worse. He couldn’t even hang up a shirt or pick up a pile of magazines on the floor. His arm would lock down every night. And took as much as 3 painkillers every night before sleep. As days passed, things only got worse. Then someone told him to give Platelet-Rich Plasma a shot. At this point, he was considering the OS’s original recommendation for the replacement surgery. But thought he’d try Platelet-Rich Plasma before that.

Bernie was also working with a Physiotherapist at that time. Both the PT and OS said it’s doubtful that Platelet-Rich Plasma would be beneficial – not only because the OA had advanced but also because his shoulder has 3 tears and most of bones were already worn out (his humerus was basically flat.)

Anyway, they decided to give Bernie two Platelet-Rich Plasma injections. After the injections, Bernie was told to continue the painkillers as the PRP would take some time to take effect. But what Bernie experienced was something totally unexpected.

He started improving almost immediately. And stopped taking the painkillers after two nights.

In the next two months, his shoulder became problematic only on 2-3 occasions – all while performing all the activities that he couldn’t previously perform, including activities that he wouldn’t dare think of before the injections. For example, he could ride the lawn mower for more than 45 minutes.

Needless to say, both the OS and the PT was impressed.

After seven months, Bernie has reported that he’s sleeping most nights without painkillers. After about a year, Bernie came back to say he has even less pain now. He haven’t been to the PT or the OS in several months.

Now take a guess. No points for the right answer though. Do you think Bernie will recommend PRP to others?

Check out our PRP Kit here.

How to choose the best Platelet-Rich Plasma Kit

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5 Ways Platelet-Rich Plasma Is Relieving Pain in America

Few things are as life-shrinking as chronic pain. Health economists report that chronic pain costs our nation more than $635 billion each year in medical treatment and lost productivity – more than cancer, heart disease and diabetes. Painkillers have been the only relief medication in modern history. That’s changing with Platelet-Rich Plasma. It has been emerging as one of the key players in pain management.

In any life that’s exclusively ruled by pain, Platelet-Rich Plasma has the power to bring back pleasure and normalcy. It’s certainly a better option for those who’re getting by on four or five Advils a day and wondering what the long term consequences would be.

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First of all, Platelet-Rich Plasma injections are completely safe. The PRP, prepared by centrifuging the patient’s blood in a special blood tube, works in a two step way. First the injections, often guided by ultrasound, breaks up the tissues and second, the growth factors in the PRP helps rebuild the entire tissue. This produces a healing effect and reduces pain.

Here are five common types of pain that can be healed with Platelet-Rich Plasma.

1. Arthritis pain

It’s been well-proven that a few shots of Platelet-Rich Plasma can produce a huge effect for Arthritis patients. It has the potential to…

  • Inhibit inflammation and thus slowing down degeneration
  • Stimulate cartilage formation
  • Kickstart the production of lubricating fluid

These activities in the affected site ends up reducing the pain sensation.

As a long term effect, Platelet-Rich Plasma injections tend to preserve the joints in more than 70% of the cases – as reported by a landmark study in 2013. Recent studies have shown similar results too. They discovered that a two or three injection treatment over a period of 4-6 weeks with Platelet-Rich Plasma does more benefit that similar injection treatments with either Corticosteroids or Hyaluronic Acid. Moreover, the cartilage degeneration was significantly slowed even for patients in advanced stages of Osteoarthritis.

The researchers also conclude that repeating the injections after 6 months ensured better results.

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2. Neurological pain

Platelet-Rich Plasma is one heck of a wonder treatment whose healing potential seems to be expanding everyday and seems like it’s only limited by the physician’s imagination. The latest of those new discoveries is in the field of nerve regeneration and the resulting neuropathic pain. Nerve fibers consisting of neurons are very delicate structures and not much has been discovered about its operating mechanism. But recently, platelet rich plasma have been shown to promote the restoration of nerve fibers.

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In a study performed at Hasanuddin University in Indonesia, Platelet-Rich Plasma was successful in nerve regeneration for patients with leprosy peripheral neuropathy – a situation where all traditional treatments have failed. Which means PRP injections are effective in restoring sensations when it has been lost. This is remarkable news.

Then there is another study conducted in Greece the shows very encouraging mid-term results regarding PRP for treatment of Carpal tunnel syndrome.

All of this is proof that Neuropathic pain can be alleviated by Platelet-Rich Plasma. This paper by a researcher at the University of Puerto Rico analyses how Platelet-Rich Plasma has been able to eliminate neuropathic pain. He reports that PRP’s ability to promote axon regeneration is the key.

Here’s a video from a Rejuv Medical where a patient explains how she had PRP Injections for Nerve treatments and how it changed her life remarkably.

3. Chronic back pain

Chronic back pain and sciatica are mysterious conditions and physicians generally have a hard time figuring out what’s causing them. They first thing they do is to scan the lower back area for defects. When they find one, they’ll recommend surgery to correct that defect even though they have no idea if that defect is indeed the culprit of the pain. When they can’t find any defects, they end up being puzzled and sent the patient away with a bunch of Advils.

In a spine health forum, a patient explains his situation which was similar. His physician suspected the tears in L4-L5 spine segment to be the causing the pain. But there were minor tears and bulges everywhere, so the physician was confused. The patient ended up having to take 8 Advils a day. Unable to continue with that, the patient skeptically tried Platelet-Rich Plasma injections. He went from not being able to sit back in office or drive in a car (even with those medications) to stopping the medications altogether and going on a family trip overseas. Talk about a dramatic shift in life experience!

Another patient on the same forum describes how she had PRP injection for chronic pain in the cervical spine, and it’s been pain-free for two years.

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These kind of stories are supplemented by occasional clinical studies like this where the patients not only had experienced near complete pain relief but also were able to sustain those results for 2 years. This is remarkable for a degenerative disease, aka, a condition that worsens as time goes by. Here are another study conducted in China and another one by Japanese researchers.

4. Joint Pain

In addition to back and knees, almost all other joints are being treated by Platelet-Rich Plasma now. As the science of PRP evolves, the treatment is vigorously gaining popularity with more and more patients demanding it from their physicians. After all, the procedure is incredibly straightforward and is easily understood by most. The physicians hardly need to talk before the patient accepts eagerly.

Hence the doctors are now quick to prescribe Platelet-Rich Plasma for any case of chronic bursitis – in areas like fingers, elbow, toes, hip, shoulders, neck, wrist, ankle, and hip – and the results are almost always positive.

In fact, Platelet-Rich Plasma can be – and must be – prescribed for more than 50% of the musculoskeletal issues that are usually treated with surgery or steroid injections.

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5. Post surgical pain

Surgical pain relief is one of the newer areas where Platelet-Rich Plasma is gaining ground. This is primarily to take advantage of the wound-healing and bone regeneration aspects of PRP, but pain-relief is a very evident beneficial side-effect. Some medical perfusionists advice Platelet-Rich Plasma after almost all surgeries including Neurosurgery, Tumor removal surgery, Oral and Maxillofacial Surgery, Head and Neck Surgeries, Reconstructions and Cosmetic Surgery, Orthopedic/Spinal Surgery, Hand and Foot Surgery, Bone Graft Surgery, Cardiothoracic Surgery and Bariatric Surgery.

By cutting short the time it takes to heal from the wounds of surgery, Platelet-Rich Plasma plays a pivotal role in assisting patients get productive as early as possible. And when done in conjunction with surgery, Platelet-Rich Plasma injections are almost always paid for by the insurance provider covering the surgery.

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The beginning of the end of orthopedic surgery?

At a time when big hospitals are racing towards a possible automation of orthopedic surgeries, there are some physicians who believe that the rise of Platelet-Rich Plasma together with the rise of stem cell technology marks the beginning of the end for 80% of the orthopedic surgeries. They say science is finally waking up to the fact that human intervention is not the most efficient way of dealing with musculoskeletal issues. Rather, it’s best to provide the necessarily biologics in the form of PRP and stem cells so that the body can invoke it’s own healing.

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I hope you agree – because today’s regenerative medical trends are certainly pushing the medical industry in that direction.

If you haven’t started offering Platelet-Rich Plasma – or would like to know some general protocols, we would love to share them with you. Just call us at (844) 377-7787 or email via hello@drprpusa.com.

TOP PRP TREATMENTS DRPRP DOCTORS
Dear Doctor, These 7 PRP Treatments Are Hot In Your State

It takes 15-20 minutes to draw 20cc of the patient’s blood, mix it with a small amount of citrate and spin it using a special prp kit and a matching centrifuge for producing the Platelet-Rich Plasma you need for most PRP treatments.

That’s what it takes to produce a multi-potential healing aid to speed up your patients’ recovery.

And it’s definitely the best free healing agent that contains growth factors, and platelets which stimulate the influx of macrophages, stem cells and other repair cells.

The Advantages of Doing PRP, The Right Way

Of course, you can create your own PRP easily by putting the blood in a test tube and spinning it in a generic table top centrifuge and no one can tell the difference. However, it may not have any platelets and probably no tissue healing proteins.

If you do it right way, using the right equipment, you can generate PRP with 7x the normal platelet concentrations. This is called Enhanced PRP. You can also use adipose tissue or collagen fibers to hold the PRP material and form a PRP matrix to amplify the effects.

The 5 Type Of Treatments That Are Hot Right Now

People who are new to Platelet-Rich Plasma may have a hard time believing in the scope of healing it offers. The best 5 treatments are the following:

1. PRP Facial Treatments

A whole lot of skin centers thrive just because they are one of the first ones to offer Platelet-Rich Plasma treatments. This is kind of a treatment that doesn’t need much convincing since there’s no side effects and no down time. Popular prp treatments for face include wrinkle reduction, eye bag and dark circle reduction, skin rejuvenation, gum lift (PRP with collagen sponge is injected after removing stitches in the gum), rosacea reduction, lip augmentation (using a combination of fat and PRP, brought to the limelight by Kylie Jenner and Charlotte Crosby), and vitiligo correction (PRP injection in combination with narrowband-ultraviolet B (NB-UVB) phototherapy improves re-pigmentation).

An especially generic and popular treatment is a combination of Platelet-Rich Plasma and Microneedling. When applied, this novel treatment can produce the effect of botox, lipo or facelift for far less cost.

TOP  PRP TREATMENTS DRPRP DOCTORS

2. PRP Hair Loss Treatments

The growth factors in Platelet-Rich Plasma can reverse non-genetical, early-stage hair loss patterns. There is a huge market for this procedure and very little practitioners offering it. It’s one of the areas for Platelet-Rich Plasma that has a huge unrealized potential. Clients also have seen successful results in cases of thinning hair and even beard regrowth.

TOP  PRP TREATMENTS DRPRP DOCTORS

3. PRP For Arthritis And Cartilage Repair

More than $6.4 billion worth of Arthritis treatments were performed in the US in 2013 alone. That number is poised to hit $9 billion by 2020. And study after study are showing how PRP can not only reduce arthritis symptoms but also regenerate the knee cartilage, something which no other mode of treatments have been able to do.

PRP treatments for Temporomandibular Joint Osteoarthritis (TMJ) is one of the most in-demand ones.

TOP  PRP TREATMENTS DRPRP DOCTORS

4. PRP for Anti-Aging

There are several high end products and complicated procedures that are popular in the Anti-Aging market. None can rival Platelet-Rich Plasma in it’s effectiveness and simplicity. Hence there is a high demand for Anti-Aging-related PRP treatments. PRP combined with Microneedling procedure can be used for acne scars, open pores, stretch marks, hand rejuvenation, Lichen Sclerosus (skin condition in vulva), melasma and breast augmentation.

Another popular treatment is injections of fat mixed with PRP to improve the appearance of cellulite on hip and butt.

5. PRP for Pain Relief And Musculoskeletal Healing

Okay, so this is a very broad category where PRP is considered as the first-line treatment. Most talked about treatments in this category are for Achilles Tendonitis, Rotator Cuff, Tennis elbow, MCL Tear, Meniscus Tear, Plantar Fasciitis, Patellar Tendonitis, Piriformis Syndrome (Severe Buttocks Pain), ACL Tear, Failed Spine Surgery, Back Pain, Lower Back Pain, Hip and Pelvic Disorders, Degenerative Disc Disease, Golfer’s Elbow, Acromio-Clavicular Joint Pain, Labaral Tear, Bursitis, Neuropathic Pain Relief (Nerve Regeneration -Platelet Lysates are used where inflammation is an issue), Spinal Stenosis or Neck Pain, Avascular Necrosis (Osteonecrosis) Or Dying Bones.

Unlike the PRP treatments in the other categories, almost all of these PRP treatments in this category are placed under ultrasound guidance directly onto the affected tissue. Patients often see really good results in as little as two weeks.

TOP  PRP TREATMENTS DRPRP DOCTORS

6. PRP For Infertility

The treatment known as Ovarian Rejuvenation where Platelet-Rich Plasma is directly injected to the patient’s ovaries to reverse menopause or heal fertility issues. This treatment can also result in sexual regeneration. However, this is different from those treatments where PRP is injected into vagina for treating incontinence, looseness, dryness and lack of drive.

Another treatment is for reduction of Vaginal Atrophy symptoms using a combination of Lipofilling and PRP.

TOP  PRP TREATMENTS DRPRP DOCTORS

7. PRP treatments for COPD (Chronic Obstructive Pulmonary Disease)

Recently, physicians are also using PRP for treating lung problems such as allergies, asthma and COPD. The Platelet-Rich Plasma is mixed with with saline and inhaled through the nebulizer for regeneration of lung tissues.

It takes 1-2 months for the treatment to take full effect – but patients are seeing great results. One patient with COPD had his best lung condition in 7 years just 2 months after the treatment. Considering that COPD is a huge issue affecting the lives of more than 700,000 Americans every year, this is major feat.

Honorable mentions

PRP for Dry Eyes: This is one of those health categories where Platelet-Rich Plasma surprised everyone with the results. This treatment is catching up fast although PRP hasn’t become the de-facto treatment.

Erectile Disfunction: This is a widely popular treatment with mixed results. The treatment is popular because of it’s low-risk profile and potential high up side (literally!)

The Future Is Looking Bright

In summary, the trend for PRP is strong – and is here to stay. It’s not a one-trick pony. After all, it’s a natural healing mechanism. And the whole procedure takes a maximum of 60 minutes for the patients with zero recovery time.

That’s why thousands of clinics and major medical establishments are making it a standard treatment for many of the medical conditions they specialize in.

We are already seeing huge the demand for PRP treatments. We receive enquiries from patients who can’t find doctors doing PRP treatments in their area – and often times they are willing to travel for the treatments. This shows how bad the demand is.

So are you offering PRP treatments or are you missing out on this easy, life-saving treatment?

Jump on board with the best PRP Treatment accessories. 🙂

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Why Insurance Will Soon Start Paying For PRP Injection

As a nation, we’re already seeing big movements in the adoption of Regenerative Medicine. Last November’s 21st Century Cures Act and the recent Arkansas HB2014 bill are just two examples. We believe it’s a matter of time before mainstream insurance companies will not only approve PRP Injection (at least for selected cases) but insist on it as an alternative to Corticosteroid injections and Hyaluronic Acid injections.

Athletes who have PRP injections instead of the standard anti-inflammatory drugs is a regular feature in Sports news these days. The Met’s Steven Matz had a platelet-rich plasma injection on last Wednesday. Last month it was David Wright.

DRPRP PRP INJECTION INSURANCE CORTICOSTEROID

We covered the case against Hyaluronic injections here.

And recently there has been larger scale studies in China. First it was from Shanghai Jiaotong University School of Medicine earlier in January. It included 14 Randomized Controlled Trials comprising 1423 participants and has shown that PRP Injection is more effective in the treatment of knee OA in terms of pain relief and functional improvement compared with saline placebo, HA, Ozone, and Corticosteroids. This is a randomized controlled trial with level 2 evidence. Full study here.

More recently it was a study at Chongqing Medical University, China that included 10 randomized controlled trials with a total of 1069 patients which found out that compared to HA and saline, PRP injection is more effective for pain relief and functional improvement in patients with symptomatic knee OA. You can read the full brief here.

And now, we also have a new randomized, double-blinded clinical trial confirm that Platelet-Rich Plasma injections can perform as well as Corticosteroid injections.

Back here in the US, researchers have been busy too. They did this double-blind Randomized Controlled Study on Lumbar Intradiskal PRP Injections for Low back pain (LBP). And as expected, PRP group showed significant improvements in FRI, NRS Best Pain, and NASS patient satisfaction scores over 8 weeks compared with controls. Full brief here.

DRPRP PRP INJECTION INSURANCE CORTICOSTEROID

A Significant Win for PRP Injection

Every year, tens of millions of injections are given for OA knees. Out of these, only a tiny fraction are PRP Injections. The majority injections are corticosteroid or HA injections. Which only accelerates the knee degeneration. Which means most of these patients go on to have the expensive and traumatic knee surgery leading to over 1 million the knee-replacement surgeries performed annually worldwide.

The question now is…

Why are we continuing to use the expensive, side-effects-ridden Corticosteroid or HA injections for Arthritis symptoms? It’s important to note that one of the side-effects of Corticosteroid injections is Osteoporosis. That’s why many physicians insist on a bone density test before these steroid injections.

Platelet-Rich Plasma Arthritis Doctor

The bottom line is that the steroid injections which were introduced in 1948 as a standard treatment for spine and sports injuries should be replaced by PRP Injections.

Or else we’ll continue having 3.5 million knee replacements costing insurance – at $25K per pop, an astounding $87.5 billion – a sum that ordinary, healthy citizens help pay.

The Problem: 90% Of Patients Call, Only 10% Take It

This statistic will hit you in the head right away the moment you start looking at the Platelet-Rich Plasma industry. I mean, the science of Platelet-Rich Plasma is simple. So everyone understands the risks (or the lack thereof). And almost all patients with wanted an extra hand in healing of tendons, ligaments, muscles & joints would love to try PRP injections.

But they don’t want to pay for it. Understandably. Because they are paying dearly every month for their insurance and why should they paying this PRP injections? It’s not patient’s fault. They shouldn’t be paying for it when they are paying for and expecting world-class medical coverage.

Platelet-Rich Plasma PRP Injection Doctor HB2014

PRP market has climbed to an estimated $120 million in 2016. If people can vote for this treatment with $120 million of their own money, without any single red cent from the big pharma, there’s definitely something the 90% of the interested-but-refuse-to-pay patients miss out on.

DRPRP PRP INJECTION INSURANCE CORTICOSTEROID

We Need To Work On Standardization Of PRP Injections

One thing researchers agree is that we need standardization. For instance, doctors now are unsure of the duration PRP Injection’s benefits last. If we have a prolonged condition like arthritis, should injections be given at a monthly interval or twice a month? Or should the injection be repeated at all? Because there are several studies that trace PRP Injection’s effects up to a period of 24 months.

All we need is studies that confirm the best practices that the PRP market is already following in terms of

  1. Concentration of the platelets and RBC in the preparation.
  2. Frequency of intra articular injections needed.
  3. Security measures to prevent overuse of this novel procedure.

Then it’ll be easy for insurance companies to trust PRP Injections as a valid procedure to not only help heal their members without any side-effects or complications but also help them avoid expensive surgery. Now, that’s what’s called a win-win-win.

You see the big winner probably will be the insurance.

So it makes sense for insurance companies to take the lead in implementing the standardization procedures since the big pharma is not interested as they stand to gain nothing.

Is that what will happen? Let’s wait and see.

Platelet-Rich Plasma Pro Athletes Injection-1
21 Pro Athletes Saved By Platelet-Rich Plasma In 2016

When Los Angeles Ace Garrett Richards ended up with a disastrous lengthwise tear along his ulnar collateral ligament last May, the high-profile hurler was staring at the famed Tommy John surgery and the disappearance of a good two years of his pitching career.

He wanted neither.

So he sought an alternative option.

And through that option, he’s back starting the season this year, just six months later.

Not surprisingly, Platelet-Rich Plasma had a major role in that. (He had stem cells injection and then PRP)

The year 2016 has been extremely good for PRP – it’s popularity is catching like wildfire. We feel that a tipping point has reached where even weekend warriors who’re unfamiliar with Orthobiologics, instantly demand Platelet-Rich Plasma for conditions like partial ligament tears.

We wanted to find out why this trend is happening.

The answer we suspect is – the numerous successful cases of pro athletes who’ve dodged surgeries like Tommy John with nothing but Platelet-Rich Plasma and rest. This is huge. Because for years, Tommy John surgery is said to have saved the careers of hundreds, if not thousands, of professional athletes around the world.

Tommy John is not only recommended for Ulnar Collateral Ligament tears – not doing it is considered a “career suicide.” That and a tough, year-long road to recovery, we might want to add.

Fortunately now, there’s at least one alternative – PRP.

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Platelet-Rich Plasma Cuts Downs Healing Time By 50%

We’ve had physicians who say they’re seeing hamstring strains that typically has about a six-week healing window heal completely in three-weeks. They are astounded. Typically natural treatments should have LONGER healing window than traditional treatments. But here, we’re talking about hundreds of cases where it’s actually cut down by 50% or more – and this is the most natural (and simple) of all treatments.

PRP just concentrates the body’s own healing resources to where needs it most!

The 50% cut in healing time is just a bonus actually. For both pro athletes and weekend warriors, preventing being cut on and having surgery is their No. 1 priority. They don’t want to just jump on right into a surgery. So even if Platelet-Rich Plasma took TWICE the time to heal, it would have been a popular option anyway… for avoiding surgery.

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Garrett Richards says “[my condition] has only gotten better since it happened, so I’m a believer.”

“I’m sore in all the right spots — everywhere I’m usually sore, and should be sore,” he adds with a smile. “It’s nice to know that I’ll be able to start the season this year and kind of pick up where I left off.”

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With that said, let’s look at what may be the real reason for growth in PRP adoption in 2016 – the huge number of high-profile pro athletes who’ve had Platelet-Rich Plasma injections in 2016.

21 Biggest American Pro Athletes Who’ve Had PRP In 2016

This USA-only list is not all-inclusive and I’m sure we have omitted a lot. But this list should give you an idea of how popular this treatment really is.

  • 1. As we mentioned above, Garrett Richards had platelet-rich plasma injection for healing the pitcher’s partially torn elbow ligament. He’s confident of his comeback without Tommy John.
  • 2. Stephen Curry had Platelet-Rich Plasma for a grade 1 MCL sprain during Game 4 of the team’s first-round series against the Houston Rockets in 2016.
  • 3. In November, Los Angeles Lakers’ D’Angelo Russell got a platelet-rich plasma injection to alleviate pain in his left knee. After having the injection on Nov 23, he missed 11 games to pave way for full recovery.
  • 4. Philadelphia 76ers Jerryd Bayless also got his PRP to heal his wrist in November. But one thing he didn’t do after Platelet-Rich Plasma was rest. He continued playing so healing didn’t happen. And he was under immense pressure to stop the season and do surgery to get well for the next season, which is what he eventually did in December.
  • 5. New York Mets catcher Travis d’Arnaud received a platelet-rich plasma injection in his ailing right shoulder. His was a strained rotator cuff. Today, word is out that he is 0-for-5 in his attempt to throw out base stealers this season.

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  • 6. Boston Celtics All-Star point guard Isaiah Thomas received a platelet-rich plasma injection Wednesday for a groin strain during the first half of his team’s loss to the Houston Rockets. He had the injection into his thigh muscle.
  • 7. Another New York Mets player Asdrubal Cabrera received platelet-rich-plasma injection in New York to accelerate healing of the strained patellar tendon of his left knee.
  • 8. The Washington Nationals star Stephen Strasburg received Platelet-Rich Plasma for his strained flexor mass in his right elbow. And now he’s back in the game for 2017 spring training.
  • 9. Philadelphia Phillies Aaron Nola, the 23-year-old right-hander, received a platelet-rich plasma injection to treat his strained right-elbow ligament. This season, he is quoted to have said that his elbow is “100 percent” healed.
  • 10. The Detroit Pistons point guard Reggie Jackson had platelet-rich plasma (PRP) injections to treat left knee tendinosis and a ulnar collateral ligament sprain in his right thumb that was bothering him for quite some time.
  • 11. San Francisco Giants center fielder Angel Pagan received a platelet-rich plasma injection for patella tendinitis in his right knee, something he believes was the result of his diving catches against the wall.
  • 12. Cleveland Indians right-hander Danny Salazar had platelet-rich plasma injection for a mild strain to his flexor musculature of his forearm.
  • 13. Red Sox’s Koji Uehara: Receives PRP injection for his pectoral injury before signing a one-year, $6 million contract with the Chicago Cubs.

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  • 14. New York Mets’ Steven Matz received platelet-rich-plasma injection to avoid surgery in his left shoulder. He believes 2017 will be a turning point for him and aims to do at least 30 starts next season.
  • 15. Texas Rangers slugger Josh Hamilton had platelet-rich plasma injection during his spring training. He later had to under surgery and then again given Platelet-Rich Plasma for healing him this year. The good news is, in February this year, an MRI scan of his left knee showed no structural damage.
  • 16. San Diego Padres’ right-handed relief pitcher Jon Edwards had platelet-rich plasma (PRP) when a right elbow MRI showed wear on his ulnar collateral ligament. Today, he’s in for his team’s spring training.
  • 17. Baltimore Orioles ace Chris Tillman had platelet-rich plasma injection on his right shoulder in December.
  • 18. Cleveland Cavaliers guard Mo Williams, the 13-year veteran, received a platelet-rich plasma injection in the knee before helping the team win the NBA finals.
  • 19. Atlanta Falcons defensive lineman Adrian Clayborn had platelet rich plasma injections to help him get back to the field faster than anticipated after he had a surgical procedure for a meniscus tear and a torn medial collateral ligament in his left knee. His doctor hopes PRP will help regenerate the lost tissue and allow the knee to heal faster while preventing scar tissue.
  • 20. Washington Wizards center Ian Mahinmi underwent platelet-rich plasma treatment on both knees during his after-surgery rehabilitation process as he aggravated the patellar tendinitis on his right knee (which he had surgery for) and suffered a bone bruise in his left knee.
  • 21. Colorado Rockies’ Gerardo Parra received a platelet-rich plasma injection for an injury he had been trying to overcome for months. He injured his left ankle in a collision with Trevor Story on June and had the Platelet-Rich Plasma in October.

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Platelet-Rich Plasma Vs Hyaluronic Acid
Did Platelet-Rich Plasma Just Crush $13 Billion Hyaluronic Acid?

While it didn’t take us by surprise when we saw Platelet-Rich Plasma win yet another bout with Hyaluronic Acid, the scientific community is pretty much over-the-top with this latest result. This is the first time there is really hard, convince-any-hard-core-critics evidence that Platelet-Rich Plasma indeed might be the new accepted non-surgical treatment for symptomatic OA.

This new study was headed by Brian Cole of Rush University Medical Center.

For those who don’t know what that means, here’s a brief summary.

  1. Rush University Medical Center is ranked #4 in the nation by U.S. News & World Report and the highest rated in Illinois.
  2. Dr. Brian Cole is the associate chairman and professor of Department of Orthopedics and chairman of Department of Surgery at Rush.
  3. He is also the Chairman of Surgery at Rush Oak Park Hospital.
  4. He has published more than 1,000 articles and 10 popular textbooks in orthopedics and regenerative medicine.
  5. He is known as one of the “Best Doctors in America” and was NBA Team Physician of the Year in 2009.
  6. He is also the head team physician for the Chicago Bulls NBA team and co-team physician for the Chicago White Sox MLB team.
  7. Dr. Cole also co-hosts Sports Medicine Weekly on ESPN Radio.

As you can see, this is kinda huge.

That’s why we’re celebrating it.

You can read information about Dr. Brain Cole’s study here.

How This Study Was Conducted

This study was performed on 111 symptomatic unilateral knee OA patients over a period of one year. Forty-nine patients were injected with Platelet-Rich Plasma and fifty patients were injected with Hyaluronic Acid, both under ultrasonic guidance. This was repeated 4 times. Both groups did not have any change in WOMAC score but IKDC score in the PRP group was significantly higher.

And as the paper reports, “significant improvements were seen in other patient-reported outcome measures” which they suspect was due to the anti-inflammatory properties of Platelet-Rich Plasma.

Why Was Hyaluronic Acid Injected In The Past

To fully understand the scope of this new study outcome, let’s discuss the role of Hyaluronic Acid in treating Osteoarthritis. As you know, Hyaluronic Acid is a critical substance in the synovial fluid that allows the bones to glide against one another. And lack of Hyaluronic Acid leads to breakdown of synovial fluid causing joint pain and stiffness that’s associated with Osteoarthritis.

So theory is that injecting Hyaluronic Acid into synovial fluid makes it thicker again.

However, what decades of study has shown is that it’s not as simple as that. Hyaluronic acid has a lot of other activities in the joint and the supplemental, bioengineered HA Hyaluronic Acid does not seem to pick those activities up naturally. That’s why doesn’t actually help improve the synovial fluids.

Platelet-Rich Plasma Vs Hyaluronic Acid

A $13 Billion Dollar Industry To Be Taken Over By Platelet-Rich Plasma?

Reports by industry analysts pegs the worldwide Hyaluronic Acid market (majority) to over $13 Billion. The market is divided into four sections according the application of HA 1) dermal fillers 2) osteoarthritis 3) ophthalmic and 4) vesicoureteral reflux. In THREE of these FOUR divisions, Platelet-Rich Plasma is already proven as a worthy substitute.

Let’s take a look:

  1. With the help of this instrument, Platelet-Rich Plasma produces dermal fillers that can match Hyaluronic Acid fillers.
  2. Osteoarthritis, as per our discussion here, stands to gain more with Platelet-Rich Plasma than Hyaluronic Acid.
  3. For dry-eyes, Platelet Rich Plasma seems to be effective when other treatments are not. (Around 40 million people suffer from dry eyes in the U.S.)
  4. Only for vesicoureteral reflux, that Platelet-Rich Plasma has not been proved. But PRP has been found effective for urinary incontinence, so I suspect it’s a matter of time we’ll see the evidence emerging to support PRP for this.

I’m not saying Platelet-Rich Plasma will immediately capture the Hyaluronic Acid market.

At least now now.

But there is hope that we could see the market replace a huge portion of bioengineered Hyaluronic Acid with Platelet-Rich Plasma. Think about it. Instead of spending unnecessary money on HA, your patients can now choose a wholesome treatment that actually gives amazing “side effects” to their body.

What It Means For OsteoArthritis Patients

If you’re a doctor, what this means is that you can stop using hyaluronic acid injections altogether, and instead confidently suggest Platelet-Rich Plasma for your patients. Even if insurance does not cover Platelet-Rich Plasma injections, it is a far more optimum treatment than the bioengineered Hyaluronic Acid.

I believe it’s only a matter of time that the insurance companies will realize why it’s actually cheaper and more effective to do Platelet-Rich Plasma than Hyaluronic Acid.

Platelet-Rich Plasma Vs Hyaluronic Acid

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